CA3060424A1 - Novel glp-1 receptor modulators - Google Patents
Novel glp-1 receptor modulators Download PDFInfo
- Publication number
- CA3060424A1 CA3060424A1 CA3060424A CA3060424A CA3060424A1 CA 3060424 A1 CA3060424 A1 CA 3060424A1 CA 3060424 A CA3060424 A CA 3060424A CA 3060424 A CA3060424 A CA 3060424A CA 3060424 A1 CA3060424 A1 CA 3060424A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- ring
- alkyl
- independently
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KTYXOXNHFFZAHY-UHFFFAOYSA-N CCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(CN(CC(O)=O)C(CNC(Cc3cccc(OC)c3)=O)=O)cc2)nc1 Chemical compound CCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(CN(CC(O)=O)C(CNC(Cc3cccc(OC)c3)=O)=O)cc2)nc1 KTYXOXNHFFZAHY-UHFFFAOYSA-N 0.000 description 1
- XLFXYBVOPMJDDR-UZNLYWMJSA-N CC[C@H](CC1)CC[C@@H]1C(CC1)CC=C1c1cnc(-c2ccc(CN(CC(O)=O)C(CNC(CN(c3cccc4c3cccc4)S(C)(=O)=O)=O)=O)cc2)nc1 Chemical compound CC[C@H](CC1)CC[C@@H]1C(CC1)CC=C1c1cnc(-c2ccc(CN(CC(O)=O)C(CNC(CN(c3cccc4c3cccc4)S(C)(=O)=O)=O)=O)cc2)nc1 XLFXYBVOPMJDDR-UZNLYWMJSA-N 0.000 description 1
- KCDJDEMZOJAUIQ-JDYUXLHCSA-N CC[C@H](CC1)CC[C@@H]1C(CC1)CC=C1c1cnc(-c2ccc(CN(CC(O)=O)C(CNC(CNS(c3c(cccc4)c4ccc3)(=O)=O)=O)=O)cc2)nc1 Chemical compound CC[C@H](CC1)CC[C@@H]1C(CC1)CC=C1c1cnc(-c2ccc(CN(CC(O)=O)C(CNC(CNS(c3c(cccc4)c4ccc3)(=O)=O)=O)=O)cc2)nc1 KCDJDEMZOJAUIQ-JDYUXLHCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491892P | 2017-04-28 | 2017-04-28 | |
| US62/491,892 | 2017-04-28 | ||
| PCT/US2018/029597 WO2018200833A1 (en) | 2017-04-28 | 2018-04-26 | Novel glp-1 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3060424A1 true CA3060424A1 (en) | 2018-11-01 |
Family
ID=62117189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3060424A Pending CA3060424A1 (en) | 2017-04-28 | 2018-04-26 | Novel glp-1 receptor modulators |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11530205B2 (https=) |
| EP (1) | EP3615524B1 (https=) |
| JP (1) | JP7116745B2 (https=) |
| AU (1) | AU2018260686B2 (https=) |
| CA (1) | CA3060424A1 (https=) |
| ES (1) | ES2937835T3 (https=) |
| WO (1) | WO2018200833A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109503510B (zh) * | 2019-01-03 | 2020-07-03 | 山东大学 | 一种防龋抗菌的噻唑类化合物及其制备方法 |
| GB201908453D0 (en) * | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
| IL310377A (en) | 2021-08-30 | 2024-03-01 | Mindrank Ai Ltd | Novel aryl ether substituted heterocyclic compound as glp1r agonist |
| CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
| TW202521533A (zh) | 2023-09-14 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| US12291530B1 (en) | 2023-11-24 | 2025-05-06 | Ascletis Pharma (China) Co., Limited | GLP-1R agonist and therapeutic method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6007417B2 (ja) * | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| AU2012352349B2 (en) | 2011-12-12 | 2017-08-17 | Receptos Llc | Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes |
| CN109867630A (zh) * | 2013-06-11 | 2019-06-11 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
| KR101651505B1 (ko) * | 2014-05-02 | 2016-08-29 | 현대약품 주식회사 | 싸이클로 헥센 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| EP3172199B1 (en) * | 2014-07-25 | 2020-07-01 | Celgene International II Sarl | Pyrimidine derivatives as glp-1 receptor modulators |
| AU2015360364B2 (en) * | 2014-12-10 | 2020-04-30 | Receptos Llc | GLP-1 receptor modulators |
-
2018
- 2018-04-26 ES ES18723347T patent/ES2937835T3/es active Active
- 2018-04-26 JP JP2019558778A patent/JP7116745B2/ja not_active Expired - Fee Related
- 2018-04-26 EP EP18723347.3A patent/EP3615524B1/en active Active
- 2018-04-26 CA CA3060424A patent/CA3060424A1/en active Pending
- 2018-04-26 AU AU2018260686A patent/AU2018260686B2/en not_active Ceased
- 2018-04-26 WO PCT/US2018/029597 patent/WO2018200833A1/en not_active Ceased
- 2018-04-26 US US16/608,134 patent/US11530205B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11530205B2 (en) | 2022-12-20 |
| ES2937835T3 (es) | 2023-03-31 |
| AU2018260686B2 (en) | 2022-03-17 |
| US20210371409A1 (en) | 2021-12-02 |
| AU2018260686A1 (en) | 2019-11-07 |
| EP3615524B1 (en) | 2022-11-09 |
| JP7116745B2 (ja) | 2022-08-10 |
| WO2018200833A1 (en) | 2018-11-01 |
| EP3615524A1 (en) | 2020-03-04 |
| JP2020518571A (ja) | 2020-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3060424A1 (en) | Novel glp-1 receptor modulators | |
| AU2015292356B2 (en) | Novel GLP-1 receptor modulators | |
| KR102271179B1 (ko) | 신규의 glp-1 수용체 조절제 | |
| ES2836973T3 (es) | Derivados de ácido carboxílico que comprenden cuatro ciclos que actúan como moduladores de receptor GLP-1 para la terapia de enfermedades tales como la diabetes | |
| JP2013530963A (ja) | 新規のｇｌｐ−１受容体安定化薬および調節薬 | |
| AU2015360364A1 (en) | GLP-1 receptor modulators | |
| HK40042919A (en) | Novel glp-1 receptor modulators | |
| NZ626122B2 (en) | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220914 |