CA3055504A1 - Method for producing 3,6-disubstituted imidazo[1,2-b]pyridazine derivative - Google Patents

Method for producing 3,6-disubstituted imidazo[1,2-b]pyridazine derivative Download PDF

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Publication number
CA3055504A1
CA3055504A1 CA3055504A CA3055504A CA3055504A1 CA 3055504 A1 CA3055504 A1 CA 3055504A1 CA 3055504 A CA3055504 A CA 3055504A CA 3055504 A CA3055504 A CA 3055504A CA 3055504 A1 CA3055504 A1 CA 3055504A1
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CA
Canada
Prior art keywords
formula
salt
compound represented
added
producing
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3055504A
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English (en)
French (fr)
Inventor
Ryoji KOIKE
Yoshifumi HACHISU
Takafumi KITAWAKI
Shohei SHIRAISHI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CA3055504A1 publication Critical patent/CA3055504A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/14—Adipic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3055504A 2017-03-14 2018-03-13 Method for producing 3,6-disubstituted imidazo[1,2-b]pyridazine derivative Pending CA3055504A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017-049138 2017-03-14
JP2017049138 2017-03-14
PCT/JP2018/009596 WO2018168815A1 (ja) 2017-03-14 2018-03-13 ３，６－ジ置換イミダゾ［１，２－ｂ］ピリダジン誘導体の製造方法

Publications (1)

Publication Number Publication Date
CA3055504A1 true CA3055504A1 (en) 2018-09-20

Family

ID=63523451

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3055504A Pending CA3055504A1 (en) 2017-03-14 2018-03-13 Method for producing 3,6-disubstituted imidazo[1,2-b]pyridazine derivative

Country Status (13)

Country Link
US (3) US11028091B2 (https=)
EP (2) EP3597648B1 (https=)
JP (4) JP7082608B2 (https=)
CN (2) CN110418792B (https=)
AU (1) AU2018234027B2 (https=)
CA (1) CA3055504A1 (https=)
ES (1) ES2947326T3 (https=)
HR (1) HRP20230764T1 (https=)
HU (1) HUE063830T2 (https=)
PL (1) PL3597648T3 (https=)
RS (1) RS64354B1 (https=)
SM (1) SMT202300269T1 (https=)
WO (1) WO2018168815A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE063830T2 (hu) * 2017-03-14 2024-02-28 Daiichi Sankyo Co Ltd Eljárás 3,6-diszubsztituált imidazo[1,2-b]piridazin származék elõállításához
AU2021453749A1 (en) * 2021-07-01 2023-12-21 Nuvation Bio Inc. Crystalline forms of 3-{4-[(2r)-2-aminopropoxy]phenyl}-n-[(1r)- 1-(3-fluorophenyl) ethyl]imidazo[1,2-b]pyridazin-6-amine and salts thereof
US20250326756A1 (en) * 2022-05-18 2025-10-23 Nuvation Bio Inc. Method for producing 3,6-disubstituted-imidazo[1,2-b]pyridazine compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60197640A (ja) * 1984-03-19 1985-10-07 Ihara Chem Ind Co Ltd ハロゲン化ニトロベンゼン類の製造方法
JPS61205220A (ja) * 1985-03-08 1986-09-11 Rikagaku Kenkyusho 一級アルコ−ル類の選択的フツ素化方法
JP3551493B2 (ja) * 1994-10-21 2004-08-04 三菱化学株式会社 新規ビスオキサゾリン化合物
AU2001260607A1 (en) * 2000-05-24 2001-12-03 Nissan Chemical Industries Ltd. Nitrile compounds and process for their preparation
JP2002193914A (ja) * 2000-05-24 2002-07-10 Nissan Chem Ind Ltd ニトリル化合物およびその製造方法
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
FR2934994B1 (fr) * 2008-08-12 2010-09-17 Sanofi Aventis Derives de 2-alkyl-6cycloamino-3-(pyridin-4-yl)imidaz°1,2-b! pyridazine, leur preparation et leur application en therapeutique
WO2013134219A1 (en) 2012-03-09 2013-09-12 Lexicon Pharmaceuticals, Inc. Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
TWI585088B (zh) 2012-06-04 2017-06-01 第一三共股份有限公司 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物
JP2016510764A (ja) * 2013-03-07 2016-04-11 カリフィア バイオ, インク.Califia Bio, Inc. 混合系キナーゼ阻害剤および治療法
US9193736B2 (en) * 2013-06-11 2015-11-24 Janssen Pharmaceutica, Nv PDE 10a inhibitors for the treatment of type II diabetes
HUE063830T2 (hu) 2017-03-14 2024-02-28 Daiichi Sankyo Co Ltd Eljárás 3,6-diszubsztituált imidazo[1,2-b]piridazin származék elõállításához
JP7648372B2 (ja) * 2020-11-30 2025-03-18 株式会社ファンケル クロロフィル含有食品用緑色退色抑制剤

Also Published As

Publication number Publication date
AU2018234027A1 (en) 2019-10-31
HUE063830T2 (hu) 2024-02-28
WO2018168815A1 (ja) 2018-09-20
JP7384963B2 (ja) 2023-11-21
JP7082608B2 (ja) 2022-06-08
JP2025123513A (ja) 2025-08-22
EP3597648B1 (en) 2023-06-07
US20210171532A1 (en) 2021-06-10
EP3597648A1 (en) 2020-01-22
US11028091B2 (en) 2021-06-08
PL3597648T3 (pl) 2023-07-24
EP3597648A4 (en) 2020-10-14
US11667642B2 (en) 2023-06-06
JP2023171735A (ja) 2023-12-05
CN114773351A (zh) 2022-07-22
CN110418792B (zh) 2022-07-05
AU2018234027B2 (en) 2021-12-09
SMT202300269T1 (it) 2023-09-06
EP3597648C0 (en) 2023-06-07
RS64354B1 (sr) 2023-08-31
ES2947326T3 (es) 2023-08-04
US20200062765A1 (en) 2020-02-27
EP4101853A1 (en) 2022-12-14
JP2022105746A (ja) 2022-07-14
HRP20230764T1 (hr) 2023-10-13
JPWO2018168815A1 (ja) 2020-04-23
US20230227459A1 (en) 2023-07-20
CN110418792A (zh) 2019-11-05

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