CA3054758A1 - Mr1 restricted t cell receptors for cancer immunotherapy - Google Patents
Mr1 restricted t cell receptors for cancer immunotherapy Download PDFInfo
- Publication number
- CA3054758A1 CA3054758A1 CA3054758A CA3054758A CA3054758A1 CA 3054758 A1 CA3054758 A1 CA 3054758A1 CA 3054758 A CA3054758 A CA 3054758A CA 3054758 A CA3054758 A CA 3054758A CA 3054758 A1 CA3054758 A1 CA 3054758A1
- Authority
- CA
- Canada
- Prior art keywords
- cell
- cells
- seq
- cell receptor
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091008874 T cell receptors Proteins 0.000 title claims abstract description 154
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title claims abstract description 141
- 238000002619 cancer immunotherapy Methods 0.000 title description 3
- 210000004027 cell Anatomy 0.000 claims abstract description 268
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 211
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 133
- 239000000427 antigen Substances 0.000 claims abstract description 67
- 108091007433 antigens Proteins 0.000 claims abstract description 65
- 102000036639 antigens Human genes 0.000 claims abstract description 65
- 201000011510 cancer Diseases 0.000 claims abstract description 63
- 238000000034 method Methods 0.000 claims abstract description 48
- 238000002360 preparation method Methods 0.000 claims abstract description 40
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 33
- 101000866855 Homo sapiens Major histocompatibility complex class I-related gene protein Proteins 0.000 claims abstract description 26
- 239000013604 expression vector Substances 0.000 claims abstract description 20
- 238000011282 treatment Methods 0.000 claims abstract description 9
- 108700019146 Transgenes Proteins 0.000 claims abstract description 8
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 6
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 6
- 210000004881 tumor cell Anatomy 0.000 claims description 55
- 230000000638 stimulation Effects 0.000 claims description 26
- 102000004127 Cytokines Human genes 0.000 claims description 24
- 108090000695 Cytokines Proteins 0.000 claims description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 22
- 239000000833 heterodimer Substances 0.000 claims description 22
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims description 16
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims description 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 15
- 239000003446 ligand Substances 0.000 claims description 14
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 12
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 12
- 238000002955 isolation Methods 0.000 claims description 12
- 238000010186 staining Methods 0.000 claims description 12
- 238000000684 flow cytometry Methods 0.000 claims description 11
- 238000001574 biopsy Methods 0.000 claims description 10
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 9
- 238000000338 in vitro Methods 0.000 claims description 9
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 8
- 102000005962 receptors Human genes 0.000 claims description 8
- 108020003175 receptors Proteins 0.000 claims description 8
- 230000001965 increasing effect Effects 0.000 claims description 7
- 210000005259 peripheral blood Anatomy 0.000 claims description 7
- 239000011886 peripheral blood Substances 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 108010002350 Interleukin-2 Proteins 0.000 claims description 6
- 238000009169 immunotherapy Methods 0.000 claims description 5
- 238000007885 magnetic separation Methods 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 102100027207 CD27 antigen Human genes 0.000 claims description 4
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 4
- 108090000172 Interleukin-15 Proteins 0.000 claims description 4
- 108010002586 Interleukin-7 Proteins 0.000 claims description 4
- 238000002659 cell therapy Methods 0.000 claims description 4
- 210000004698 lymphocyte Anatomy 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 claims description 3
- 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 claims description 3
- 239000002458 cell surface marker Substances 0.000 claims description 3
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- 102100035920 Probable hydrolase PNKD Human genes 0.000 claims 22
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000009258 tissue cross reactivity Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 23
- 238000002474 experimental method Methods 0.000 description 21
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 20
- 230000004913 activation Effects 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 241000588724 Escherichia coli Species 0.000 description 17
- 239000006166 lysate Substances 0.000 description 17
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 13
- DDBCPKAHJKOGKK-UHFFFAOYSA-N N(2)-acetyl-6-formylpterin Chemical compound O=CC1=CN=C2NC(NC(=O)C)=NC(=O)C2=N1 DDBCPKAHJKOGKK-UHFFFAOYSA-N 0.000 description 13
- 230000004044 response Effects 0.000 description 13
- 239000006228 supernatant Substances 0.000 description 13
- 239000003550 marker Substances 0.000 description 12
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 12
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 11
- 230000000259 anti-tumor effect Effects 0.000 description 11
- 230000001419 dependent effect Effects 0.000 description 11
- 230000000813 microbial effect Effects 0.000 description 11
- LLJAQDVNMGLRBD-UHFFFAOYSA-N 6-formylpterin Chemical compound C1=C(C=O)N=C2C(=O)NC(N)=NC2=N1 LLJAQDVNMGLRBD-UHFFFAOYSA-N 0.000 description 10
- 230000009257 reactivity Effects 0.000 description 10
- 238000012546 transfer Methods 0.000 description 10
- 238000012762 unpaired Student’s t-test Methods 0.000 description 10
- 239000012636 effector Substances 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 230000004936 stimulating effect Effects 0.000 description 9
- 108010092262 T-Cell Antigen Receptors Proteins 0.000 description 8
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 8
- 230000000903 blocking effect Effects 0.000 description 8
- 238000003501 co-culture Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000002147 killing effect Effects 0.000 description 7
- 201000001441 melanoma Diseases 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 101000708766 Homo sapiens Structural maintenance of chromosomes protein 3 Proteins 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 102100032723 Structural maintenance of chromosomes protein 3 Human genes 0.000 description 6
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 6
- 102220522305 THAP domain-containing protein 1_K43A_mutation Human genes 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 230000002950 deficient Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000002953 phosphate buffered saline Substances 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000002299 complementary DNA Substances 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 210000001616 monocyte Anatomy 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- 206010009944 Colon cancer Diseases 0.000 description 4
- 101000600434 Homo sapiens Putative uncharacterized protein encoded by MIR7-3HG Proteins 0.000 description 4
- 101150082764 MR1 gene Proteins 0.000 description 4
- 102100037401 Putative uncharacterized protein encoded by MIR7-3HG Human genes 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000012512 characterization method Methods 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 230000005909 tumor killing Effects 0.000 description 4
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 108090000672 Annexin A5 Proteins 0.000 description 3
- 102000004121 Annexin A5 Human genes 0.000 description 3
- 102000009410 Chemokine receptor Human genes 0.000 description 3
- 108050000299 Chemokine receptor Proteins 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 108050003558 Interleukin-17 Proteins 0.000 description 3
- 102000013691 Interleukin-17 Human genes 0.000 description 3
- 108090000978 Interleukin-4 Proteins 0.000 description 3
- 102000004388 Interleukin-4 Human genes 0.000 description 3
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 3
- 230000006044 T cell activation Effects 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000011467 adoptive cell therapy Methods 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 239000013592 cell lysate Substances 0.000 description 3
- 201000010897 colon adenocarcinoma Diseases 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 210000004443 dendritic cell Anatomy 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 208000003747 lymphoid leukemia Diseases 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 3
- 229960004276 zoledronic acid Drugs 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- SXDXRJZUAJBNFL-XKSSXDPKSA-N 6,7-dimethyl-8-(1-D-ribityl)lumazine Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C(C)=C(C)N=C2C1=NC(=O)NC2=O SXDXRJZUAJBNFL-XKSSXDPKSA-N 0.000 description 2
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 description 2
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 description 2
- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 description 2
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 description 2
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 description 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 2
- 101000939744 Homo sapiens T cell receptor beta variable 25-1 Proteins 0.000 description 2
- 102000003814 Interleukin-10 Human genes 0.000 description 2
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 102000003816 Interleukin-13 Human genes 0.000 description 2
- 108090000176 Interleukin-13 Proteins 0.000 description 2
- 108010002616 Interleukin-5 Proteins 0.000 description 2
- 102000000743 Interleukin-5 Human genes 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 102000004889 Interleukin-6 Human genes 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 206010056342 Pulmonary mass Diseases 0.000 description 2
- 239000002262 Schiff base Substances 0.000 description 2
- 150000004753 Schiff bases Chemical class 0.000 description 2
- 102100029657 T cell receptor beta variable 25-1 Human genes 0.000 description 2
- 208000000389 T-cell leukemia Diseases 0.000 description 2
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 2
- 210000000662 T-lymphocyte subset Anatomy 0.000 description 2
- 241000703392 Tribec virus Species 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 101150063416 add gene Proteins 0.000 description 2
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical group C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 210000003515 double negative t cell Anatomy 0.000 description 2
- 229940014144 folate Drugs 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 150000002433 hydrophilic molecules Chemical class 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000037451 immune surveillance Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 238000011275 oncology therapy Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 235000019192 riboflavin Nutrition 0.000 description 2
- 239000002151 riboflavin Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 239000012103 Alexa Fluor 488 Substances 0.000 description 1
- 239000012114 Alexa Fluor 647 Substances 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 102100026882 Alpha-synuclein Human genes 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102100035793 CD83 antigen Human genes 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 238000000116 DAPI staining Methods 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
- 102100021186 Granulysin Human genes 0.000 description 1
- 101710168479 Granulysin Proteins 0.000 description 1
- 102000001398 Granzyme Human genes 0.000 description 1
- 108060005986 Granzyme Proteins 0.000 description 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 description 1
- 101100383038 Homo sapiens CD19 gene Proteins 0.000 description 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 1
- 101000984189 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 2 Proteins 0.000 description 1
- 101001023733 Homo sapiens Neurotrypsin Proteins 0.000 description 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 1
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 description 1
- 101000772138 Homo sapiens T cell receptor alpha variable 1-2 Proteins 0.000 description 1
- 101000939858 Homo sapiens T cell receptor beta variable 12-4 Proteins 0.000 description 1
- 101000658404 Homo sapiens T cell receptor beta variable 29-1 Proteins 0.000 description 1
- 101000606206 Homo sapiens T cell receptor beta variable 4-3 Proteins 0.000 description 1
- 101000606208 Homo sapiens T cell receptor beta variable 5-5 Proteins 0.000 description 1
- 101000606218 Homo sapiens T cell receptor beta variable 6-1 Proteins 0.000 description 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 206010024305 Leukaemia monocytic Diseases 0.000 description 1
- 108010017736 Leukocyte Immunoglobulin-like Receptor B1 Proteins 0.000 description 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 1
- 102100025584 Leukocyte immunoglobulin-like receptor subfamily B member 1 Human genes 0.000 description 1
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
- 241001197446 Mus cypriacus Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 108010047620 Phytohemagglutinins Proteins 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100029308 T cell receptor alpha variable 1-2 Human genes 0.000 description 1
- 102100029697 T cell receptor beta variable 12-4 Human genes 0.000 description 1
- 102100034879 T cell receptor beta variable 29-1 Human genes 0.000 description 1
- 102100039757 T cell receptor beta variable 4-3 Human genes 0.000 description 1
- 102100039756 T cell receptor beta variable 5-5 Human genes 0.000 description 1
- 102100039787 T cell receptor beta variable 6-1 Human genes 0.000 description 1
- 108700042075 T-Cell Receptor Genes Proteins 0.000 description 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
- 102220521900 THAP domain-containing protein 1_K34A_mutation Human genes 0.000 description 1
- 108700012920 TNF Proteins 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 229940127174 UCHT1 Drugs 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000005809 anti-tumor immunity Effects 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
- 238000010370 cell cloning Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229960000390 fludarabine Drugs 0.000 description 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000012215 gene cloning Methods 0.000 description 1
- 238000010362 genome editing Methods 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 102000046699 human CD14 Human genes 0.000 description 1
- 102000044413 human MR1 Human genes 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000002998 immunogenetic effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000009126 molecular therapy Methods 0.000 description 1
- 201000006894 monocytic leukemia Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001400 myeloablative effect Effects 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000001885 phytohemagglutinin Effects 0.000 description 1
- 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 238000012342 propidium iodide staining Methods 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17159754.5 | 2017-03-07 | ||
| EP17159754 | 2017-03-07 | ||
| EP17179309.4 | 2017-07-03 | ||
| EP17179309 | 2017-07-03 | ||
| PCT/EP2018/055620 WO2018162563A1 (en) | 2017-03-07 | 2018-03-07 | Mr1 restricted t cell receptors for cancer immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3054758A1 true CA3054758A1 (en) | 2018-09-13 |
Family
ID=61563412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3054758A Pending CA3054758A1 (en) | 2017-03-07 | 2018-03-07 | Mr1 restricted t cell receptors for cancer immunotherapy |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP4273233A3 (enExample) |
| JP (2) | JP7233103B2 (enExample) |
| KR (1) | KR20190126332A (enExample) |
| CN (1) | CN110462024B (enExample) |
| AU (1) | AU2018231405B2 (enExample) |
| CA (1) | CA3054758A1 (enExample) |
| IL (1) | IL268813A (enExample) |
| WO (1) | WO2018162563A1 (enExample) |
| ZA (1) | ZA201905579B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3026180A1 (en) * | 2016-06-10 | 2017-12-14 | Gadeta B.V. | Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof |
| EP3624823A1 (en) | 2017-05-18 | 2020-03-25 | UMC Utrecht Holding B.V. | Compositions and methods for cell targeting therapies |
| GB201717578D0 (en) | 2017-10-26 | 2017-12-13 | Univ College Cardiff Consultants Ltd | Novel T-cell receptor |
| CN112236447B (zh) * | 2018-04-19 | 2023-10-20 | 得克萨斯州大学系统董事会 | 具有mage-b2特异性的t细胞受体及其用途 |
| CA3107859A1 (en) * | 2018-09-12 | 2020-03-19 | Universitat Basel | Mr1 restricted t cell receptors for cancer immunotherapy |
| US20210369776A1 (en) * | 2018-12-06 | 2021-12-02 | Guangdong Tcrcure Biopharma Technology Co., Ltd. | Combinational tcr-t cell therapy targeting tumor antigens, tgf-beta, and immune checkpoints |
| WO2022118043A1 (en) | 2020-12-03 | 2022-06-09 | Enara Bio Limited | Novel protein-ligand complex |
| WO2022248881A1 (en) | 2021-05-28 | 2022-12-01 | Enara Bio Limited | Novel protein-ligand complex |
| WO2023106894A1 (ko) * | 2021-12-10 | 2023-06-15 | 주식회사 유틸렉스 | Mr1 제한적 panck t 세포 및 이의 제조방법 |
| EP4472742A1 (en) * | 2022-02-03 | 2024-12-11 | University College Cardiff Consultants Limited | Novel t-cell receptor |
| CN119587561B (zh) * | 2024-12-09 | 2025-11-28 | 新乡医学院 | THP在制备增强Vγ9Vδ2 T细胞抗肿瘤疗效的药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2089229C (en) * | 1992-02-14 | 2010-04-13 | Alejandro A. Aruffo | Cd40cr receptor and ligands therefor |
| US7829289B2 (en) * | 2002-05-14 | 2010-11-09 | Institut National De La Sante Et De Recherche Medicale | T cell subpopulation regulating gut immunity |
| JP6126804B2 (ja) * | 2012-07-25 | 2017-05-10 | 国立大学法人富山大学 | Ｔ細胞受容体のクローニング方法 |
| EP2971045B1 (en) * | 2013-03-13 | 2019-06-19 | Health Research, Inc. | Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen |
| US10245262B2 (en) * | 2014-04-01 | 2019-04-02 | The University Of Queensland | Immunological reagents and uses therefor |
-
2018
- 2018-03-07 JP JP2019572845A patent/JP7233103B2/ja active Active
- 2018-03-07 CN CN201880016990.4A patent/CN110462024B/zh active Active
- 2018-03-07 KR KR1020197027180A patent/KR20190126332A/ko active Pending
- 2018-03-07 EP EP23181086.2A patent/EP4273233A3/en not_active Withdrawn
- 2018-03-07 EP EP18708695.4A patent/EP3592839B1/en active Active
- 2018-03-07 AU AU2018231405A patent/AU2018231405B2/en active Active
- 2018-03-07 WO PCT/EP2018/055620 patent/WO2018162563A1/en not_active Ceased
- 2018-03-07 CA CA3054758A patent/CA3054758A1/en active Pending
-
2019
- 2019-08-21 IL IL26881319A patent/IL268813A/en unknown
- 2019-08-23 ZA ZA2019/05579A patent/ZA201905579B/en unknown
-
2023
- 2023-02-14 JP JP2023020851A patent/JP7515209B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110462024A (zh) | 2019-11-15 |
| WO2018162563A1 (en) | 2018-09-13 |
| JP7515209B2 (ja) | 2024-07-12 |
| EP4273233A2 (en) | 2023-11-08 |
| JP2020527036A (ja) | 2020-09-03 |
| IL268813A (en) | 2019-10-31 |
| AU2018231405B2 (en) | 2024-02-08 |
| ZA201905579B (en) | 2024-08-28 |
| JP7233103B2 (ja) | 2023-03-06 |
| EP3592839C0 (en) | 2023-07-05 |
| KR20190126332A (ko) | 2019-11-11 |
| EP3592839A1 (en) | 2020-01-15 |
| EP3592839B1 (en) | 2023-07-05 |
| CN110462024B (zh) | 2024-08-09 |
| JP2023058659A (ja) | 2023-04-25 |
| EP4273233A3 (en) | 2023-11-15 |
| AU2018231405A1 (en) | 2019-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3592839B1 (en) | Mr1 restricted t cell receptors for cancer immunotherapy | |
| US20250136940A1 (en) | Nk cells with an increased antibody-dependent cellular toxicity (adcc) against tumors | |
| CN104780939B (zh) | 用于细胞免疫治疗的方法和组合物 | |
| US11702459B2 (en) | MR1 restricted T cell receptors for cancer immunotherapy | |
| ES2992909T3 (en) | Methods and compositions for preparing genetically engineered cells | |
| US20170313759A1 (en) | Novel chimeric antigen receptors | |
| US20220339271A1 (en) | Mr1 restricted t cell receptors for cancer immunotherapy | |
| KR20170068598A (ko) | 입양 세포 치료에서 복용을 위한 방법 및 조성물 | |
| US20200163992A1 (en) | Nkt-cell subset for in vivo persistence and therapeutic activity and propagation of same | |
| US20230295319A1 (en) | Chimeric antigen receptors and uses thereof | |
| KR20250048397A (ko) | 메모리 기능을 갖는 t세포 또는 b세포의 증강제, 악성 종양 재발 억제제 및 t세포 또는 b세포에 메모리 기능을 유도하는 유도제 | |
| CN111683971A (zh) | 医药重组受体组成物及方法 | |
| US20240002465A1 (en) | Mr1 restricted t cell receptors for cancer immunotherapy | |
| CA3141210A1 (en) | Modified nk-92 cells, and therapeutic and diagnostic uses thereof | |
| Stringhini | Direct and Indirect Harnessing of Cytotoxic CD8+ T Lymphocytes for Cancer Therapy: Adoptive Cell Therapy Versus Immunocytokines | |
| US20230374104A1 (en) | Methods and compositions comprising pd1 chimeric polypeptides | |
| WO2025128822A1 (en) | Lilrb3 modulators and methods of use thereof | |
| TW202132326A (zh) | Hla限制性hormad1 t細胞受體及其用途 | |
| HK40015270B (zh) | Hla限制性vgll1肽及其用途 | |
| HK1218925A1 (en) | Cs1-specific chimeric antigen receptor engineered immune effector cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220921 |
|
| EEER | Examination request |
Effective date: 20220921 |
|
| EEER | Examination request |
Effective date: 20220921 |
|
| EEER | Examination request |
Effective date: 20220921 |