CA3053909A1 - Composes excipients destines au traitement de proteines - Google Patents

Composes excipients destines au traitement de proteines Download PDF

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Publication number
CA3053909A1
CA3053909A1 CA3053909A CA3053909A CA3053909A1 CA 3053909 A1 CA3053909 A1 CA 3053909A1 CA 3053909 A CA3053909 A CA 3053909A CA 3053909 A CA3053909 A CA 3053909A CA 3053909 A1 CA3053909 A1 CA 3053909A1
Authority
CA
Canada
Prior art keywords
protein
excipient
viscosity
therapeutic
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3053909A
Other languages
English (en)
Inventor
David S. Soane
Philip Wuthrich
Robert P. Mahoney
Mark Moody
Daniel G. Greene
Neil L. Schauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Comera Life Sciences Inc
Original Assignee
Reform Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reform Biologics Inc filed Critical Reform Biologics Inc
Publication of CA3053909A1 publication Critical patent/CA3053909A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Water Supply & Treatment (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des procédés d'amélioration d'un paramètre d'un processus lié aux protéines comprenant la préparation d'un composé excipient de réduction de la viscosité sélectionné dans le groupe constitué des amines bloquées, des substances aromatiques anioniques, des acides aminés fonctionnalisés, des oligopeptides, des acides organiques à courte chaîne, et des polyacides aliphatiques de bas poids moléculaire, et l'addition d'une quantité de réduction de viscosité du composé excipient de réduction de la viscosité à une solution formant support pour le processus lié aux protéines, dans lequel la solution formant support contient une protéine d'intérêt, et des solutions formant support comprenant un milieu liquide dans lequel est dissoute une protéine d'intérêt, et un excipient de réduction de la viscosité, la viscosité de la solution formant support présentant une viscosité inférieure à celle d'une solution témoin qui est sensiblement semblable à la solution formant support excepté pour la présence de l'excipient de réduction de la viscosité.
CA3053909A 2017-02-16 2018-02-14 Composes excipients destines au traitement de proteines Pending CA3053909A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762459893P 2017-02-16 2017-02-16
US62/459,893 2017-02-16
PCT/US2018/018123 WO2018152165A1 (fr) 2017-02-16 2018-02-14 Composés excipients destinés au traitement de protéines

Publications (1)

Publication Number Publication Date
CA3053909A1 true CA3053909A1 (fr) 2018-08-23

Family

ID=63170449

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3053909A Pending CA3053909A1 (fr) 2017-02-16 2018-02-14 Composes excipients destines au traitement de proteines

Country Status (5)

Country Link
EP (1) EP3582801A4 (fr)
JP (1) JP2020507593A (fr)
KR (1) KR102572453B1 (fr)
CA (1) CA3053909A1 (fr)
WO (1) WO2018152165A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160074515A1 (en) 2014-06-20 2016-03-17 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
KR102493469B1 (ko) * 2018-03-07 2023-02-07 코메라 라이프 사이언시스, 인코포레이티드 단백질 제형을 위한 부형제 화합물
US20220348608A1 (en) * 2019-10-04 2022-11-03 Merck Patent Gmbh Purification of proteins and viral inactivation
CN113621360A (zh) * 2020-05-06 2021-11-09 中国石油化工股份有限公司 一种稠油降粘剂及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5710311B2 (ja) * 2011-02-18 2015-04-30 株式会社日立製作所 添加培地の添加制御方法、及び当該方法を用いた細胞培養装置
KR101759694B1 (ko) * 2011-10-28 2017-07-19 인테그리티 바이오, 아이엔씨. 아미노산을 함유하는 단백질 제제
EP2682168A1 (fr) * 2012-07-02 2014-01-08 Millipore Corporation Dispositif de tirage et métier à filer
ES2959451T3 (es) * 2013-09-11 2024-02-26 Eagle Biologics Inc Formulaciones proteicas líquidas que contienen organofosfatos
US20160074515A1 (en) * 2014-06-20 2016-03-17 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
KR102497368B1 (ko) * 2014-10-01 2023-02-10 이글 바이올로직스 인코포레이티드 점도-저하제를 함유하는 폴리삭카라이드 및 핵산 제형

Also Published As

Publication number Publication date
KR20190117631A (ko) 2019-10-16
JP2020507593A (ja) 2020-03-12
WO2018152165A1 (fr) 2018-08-23
EP3582801A1 (fr) 2019-12-25
EP3582801A4 (fr) 2020-12-23
KR102572453B1 (ko) 2023-08-29

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Effective date: 20190816

EEER Examination request

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EEER Examination request

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EEER Examination request

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EEER Examination request

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