KR102572453B1 - 단백질 가공 처리를 위한 부형제 화합물 - Google Patents

단백질 가공 처리를 위한 부형제 화합물 Download PDF

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Publication number
KR102572453B1
KR102572453B1 KR1020197026671A KR20197026671A KR102572453B1 KR 102572453 B1 KR102572453 B1 KR 102572453B1 KR 1020197026671 A KR1020197026671 A KR 1020197026671A KR 20197026671 A KR20197026671 A KR 20197026671A KR 102572453 B1 KR102572453 B1 KR 102572453B1
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KR
South Korea
Prior art keywords
protein
viscosity
excipient
therapeutic
formulation
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Application number
KR1020197026671A
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English (en)
Korean (ko)
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KR20190117631A (ko
Inventor
데이비드 에스. 숀
필립 위스리치
로버트 피. 마호니
마크 무디
다니엘 지. 그린
닐 엘. 샤우어
Original Assignee
코메라 라이프 사이언시스, 인코포레이티드
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Publication of KR20190117631A publication Critical patent/KR20190117631A/ko
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Publication of KR102572453B1 publication Critical patent/KR102572453B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Water Supply & Treatment (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020197026671A 2017-02-16 2018-02-14 단백질 가공 처리를 위한 부형제 화합물 KR102572453B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762459893P 2017-02-16 2017-02-16
US62/459,893 2017-02-16
PCT/US2018/018123 WO2018152165A1 (fr) 2017-02-16 2018-02-14 Composés excipients destinés au traitement de protéines

Publications (2)

Publication Number Publication Date
KR20190117631A KR20190117631A (ko) 2019-10-16
KR102572453B1 true KR102572453B1 (ko) 2023-08-29

Family

ID=63170449

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197026671A KR102572453B1 (ko) 2017-02-16 2018-02-14 단백질 가공 처리를 위한 부형제 화합물

Country Status (5)

Country Link
EP (1) EP3582801A4 (fr)
JP (1) JP2020507593A (fr)
KR (1) KR102572453B1 (fr)
CA (1) CA3053909A1 (fr)
WO (1) WO2018152165A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160074515A1 (en) 2014-06-20 2016-03-17 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
EP3761962A4 (fr) * 2018-03-07 2021-12-15 ReForm Biologics, Inc. Composés excipients pour formulations à base de protéines
EP3886909A4 (fr) * 2018-11-29 2023-03-29 Comera Life Sciences, Inc. Composés d'excipients destinés au traitement de protéines
TW202043253A (zh) * 2019-01-28 2020-12-01 美商安進公司 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程
CA3156649A1 (fr) * 2019-10-04 2021-04-08 Merck Patent Gmbh Purification de proteines et inactivation virale
CN113621360A (zh) * 2020-05-06 2021-11-09 中国石油化工股份有限公司 一种稠油降粘剂及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015196187A1 (fr) * 2014-06-20 2015-12-23 Reform Biologics, Llc Composés excipient réduisant la viscosité pour formulations à base de protéines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5710311B2 (ja) * 2011-02-18 2015-04-30 株式会社日立製作所 添加培地の添加制御方法、及び当該方法を用いた細胞培養装置
EP3578203A1 (fr) * 2011-10-28 2019-12-11 Integritybio Inc. Formulations de protéine contenant des acides aminés
EP2682168A1 (fr) * 2012-07-02 2014-01-08 Millipore Corporation Dispositif de tirage et métier à filer
EP3808338A1 (fr) * 2013-09-11 2021-04-21 Eagle Biologics, Inc. Formulations de protéine liquides contenant des liquides ioniques
AU2015325055B2 (en) * 2014-10-01 2021-02-25 Eagle Biologics, Inc. Polysaccharide and nucleic acid formulations containing viscosity-lowering agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015196187A1 (fr) * 2014-06-20 2015-12-23 Reform Biologics, Llc Composés excipient réduisant la viscosité pour formulations à base de protéines

Also Published As

Publication number Publication date
CA3053909A1 (fr) 2018-08-23
EP3582801A1 (fr) 2019-12-25
EP3582801A4 (fr) 2020-12-23
JP2020507593A (ja) 2020-03-12
WO2018152165A1 (fr) 2018-08-23
KR20190117631A (ko) 2019-10-16

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