CA3049679A1 - Inhibitors of nhe-mediated antiport - Google Patents
Inhibitors of nhe-mediated antiport Download PDFInfo
- Publication number
- CA3049679A1 CA3049679A1 CA3049679A CA3049679A CA3049679A1 CA 3049679 A1 CA3049679 A1 CA 3049679A1 CA 3049679 A CA3049679 A CA 3049679A CA 3049679 A CA3049679 A CA 3049679A CA 3049679 A1 CA3049679 A1 CA 3049679A1
- Authority
- CA
- Canada
- Prior art keywords
- bis
- diyl
- tetrahydroisoquinolin
- compound
- dioxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- QZDBZWJIQUUFBJ-UHFFFAOYSA-N 1,3-bis[2-[2-[2-[[3-(6,8-dichloro-2-methyl-3,4-dihydro-1h-isoquinolin-4-yl)phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]urea Chemical compound C12=CC(Cl)=CC(Cl)=C2CN(C)CC1C1=CC=CC(S(=O)(=O)NCCOCCOCCNC(=O)NCCOCCOCCNS(=O)(=O)C=2C=C(C=CC=2)C2C3=CC(Cl)=CC(Cl)=C3CN(C)C2)=C1 QZDBZWJIQUUFBJ-UHFFFAOYSA-N 0.000 claims 1
- QLBMPWRKWVMEPS-UHFFFAOYSA-N 1-[2-[2-[2-[[3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)-4-methylphenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)-4-methylphenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea Chemical compound CN1CC(C2=C(C)C=CC(=C2)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C2=CC(C3CN(C)CC4=C3C=C(Cl)C=C4Cl)=C(C)C=C2)C2=C(C1)C(Cl)=CC(Cl)=C2 QLBMPWRKWVMEPS-UHFFFAOYSA-N 0.000 claims 1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Pharmacology & Pharmacy (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201762444338P | 2017-01-09 | 2017-01-09 | |
| US62/444,338 | 2017-01-09 | ||
| PCT/US2018/013027 WO2018129557A1 (en) | 2017-01-09 | 2018-01-09 | Inhibitors of nhe-mediated antiport |
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| CA3049679A1 true CA3049679A1 (en) | 2018-07-12 |
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| WO2020181555A1 (zh) * | 2019-03-14 | 2020-09-17 | 深圳仁泰医药科技有限公司 | Nhe3抑制剂的晶型a及其制备方法和应用 |
| CN112679427B (zh) * | 2019-10-17 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 四氢异喹啉类衍生物、其制备方法及其在医药上的应用 |
| IL303799A (en) * | 2020-12-18 | 2023-08-01 | Shanghai Jemincare Pharmaceuticals Co Ltd | TETRAHYDROISOQUINOLINE COMPOUND IN SUBSTITUTE BENZOHETROCYCLE |
| CN114716458A (zh) * | 2021-01-04 | 2022-07-08 | 上海济煜医药科技有限公司 | 四氢异喹啉类化合物 |
| CN114805202A (zh) * | 2021-01-28 | 2022-07-29 | 江西济民可信集团有限公司 | 苯磺酰胺类化合物及其制备方法和应用 |
| CN113636960A (zh) * | 2021-08-24 | 2021-11-12 | 上海皓元医药股份有限公司 | 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法 |
| CN117462525B (zh) * | 2023-09-06 | 2024-11-15 | 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） | 衣康酸在治疗坏死性小肠结肠炎患者中的应用 |
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-
2018
- 2018-01-09 CA CA3049679A patent/CA3049679A1/en not_active Abandoned
- 2018-01-09 MX MX2019008171A patent/MX2019008171A/es unknown
- 2018-01-09 WO PCT/US2018/013027 patent/WO2018129557A1/en not_active Ceased
- 2018-01-09 EA EA201991676A patent/EA201991676A1/ru unknown
- 2018-01-09 CN CN201880011759.6A patent/CN110291082A/zh active Pending
- 2018-01-09 MA MA047203A patent/MA47203A/fr unknown
- 2018-01-09 BR BR112019013963A patent/BR112019013963A2/pt not_active Application Discontinuation
- 2018-01-09 JP JP2019537134A patent/JP2020505333A/ja active Pending
- 2018-01-09 AU AU2018206479A patent/AU2018206479B2/en active Active
- 2018-01-09 EP EP18701988.0A patent/EP3565811A1/en not_active Withdrawn
- 2018-01-09 US US16/476,835 patent/US11147884B2/en active Active
- 2018-01-09 KR KR1020197023351A patent/KR20190128626A/ko not_active Ceased
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2019
- 2019-07-03 IL IL267821A patent/IL267821B2/en unknown
- 2019-07-08 ZA ZA2019/04460A patent/ZA201904460B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190374649A1 (en) | 2019-12-12 |
| EA201991676A1 (ru) | 2020-01-30 |
| IL267821B (en) | 2022-10-01 |
| MX2019008171A (es) | 2020-02-05 |
| MA47203A (fr) | 2019-11-13 |
| BR112019013963A2 (pt) | 2020-04-28 |
| IL267821A (en) | 2019-09-26 |
| EP3565811A1 (en) | 2019-11-13 |
| AU2018206479A1 (en) | 2019-07-25 |
| ZA201904460B (en) | 2022-05-25 |
| WO2018129557A1 (en) | 2018-07-12 |
| JP2020505333A (ja) | 2020-02-20 |
| CN110291082A (zh) | 2019-09-27 |
| KR20190128626A (ko) | 2019-11-18 |
| IL267821B2 (en) | 2023-02-01 |
| US11147884B2 (en) | 2021-10-19 |
| AU2018206479B2 (en) | 2022-07-14 |
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