CA3045883C - Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging - Google Patents

Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging Download PDF

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Publication number
CA3045883C
CA3045883C CA3045883A CA3045883A CA3045883C CA 3045883 C CA3045883 C CA 3045883C CA 3045883 A CA3045883 A CA 3045883A CA 3045883 A CA3045883 A CA 3045883A CA 3045883 C CA3045883 C CA 3045883C
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Prior art keywords
cells
chemotherapy
mice
glycerol
igf
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CA3045883A
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English (en)
French (fr)
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CA3045883A1 (en
Inventor
Valter Longo
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University of Southern California USC
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University of Southern California USC
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Publication of CA3045883A1 publication Critical patent/CA3045883A1/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4172Imidazole-alkanecarboxylic acids, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CA3045883A 2008-04-24 2009-04-24 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging Active CA3045883C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4768008P 2008-04-24 2008-04-24
US61/047,680 2008-04-24
CA2722365A CA2722365C (en) 2008-04-24 2009-04-24 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2722365A Division CA2722365C (en) 2008-04-24 2009-04-24 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging

Publications (2)

Publication Number Publication Date
CA3045883A1 CA3045883A1 (en) 2009-10-29
CA3045883C true CA3045883C (en) 2022-06-28

Family

ID=41217444

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3045883A Active CA3045883C (en) 2008-04-24 2009-04-24 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging
CA2722365A Active CA2722365C (en) 2008-04-24 2009-04-24 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2722365A Active CA2722365C (en) 2008-04-24 2009-04-24 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging

Country Status (5)

Country Link
EP (1) EP2285218B1 (enExample)
JP (2) JP2011523626A (enExample)
CA (2) CA3045883C (enExample)
ES (1) ES2800327T3 (enExample)
WO (1) WO2009132320A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2676664B1 (en) * 2011-02-17 2017-06-21 EA Pharma Co., Ltd. Potentiator of antitumor activity of chemotherapeutic agent
JP5752980B2 (ja) * 2011-04-04 2015-07-22 日本メジフィジックス株式会社 腎臓トランスポーターの輸送能を抑制するための組成物
US9237761B2 (en) 2013-02-12 2016-01-19 University Of Southern California Methods and diets for lowering glucose and/or IGF-1 levels
EP3113776B1 (en) * 2014-03-06 2021-01-13 University of Southern California Use of short term starvation regimen in combination with kinase inhibitors to enhance traditional chemo-drug efficacy and feasibility and reverse side effects of kinases in normal cells and tissues
EP3115047B1 (en) * 2014-03-07 2020-05-06 Ajinomoto Co., Inc. Debility preventative
RU2724525C2 (ru) * 2015-05-06 2020-06-23 Юниверсити Оф Саутерн Калифорния Способ лечения повышенных уровней инсулина или глюкозы с использованием гипокалорийного или бескалорийного рациона или рациона, имитирующего воздержание от пищи
CN112752575A (zh) * 2018-09-27 2021-05-04 雀巢产品有限公司 组氨酸、甘氨酸和其它氨基酸用于预防胰岛素抗性和/或糖尿病的用途
US20230000888A1 (en) 2019-12-19 2023-01-05 Leibniz-Institut Für Alternsforschung - Fritz-Lipmann-Institut E.V. (Fli) Nad-precursors and dietary restriction for treating age related medical conditions
AU2020468941A1 (en) * 2020-09-23 2023-03-23 Aminovita S.L. Metabolic cancer therapy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535049A (en) 1978-09-04 1980-03-11 Otsuka Pharmaceut Factory Inc Amino acid transfusion for cancerous patient
US4574085A (en) * 1981-05-15 1986-03-04 Baxter Travenol Laboratories, Inc. Method for using dialysis solution containing glycerol
FR2591893B1 (fr) * 1985-12-19 1988-11-10 Centre Nat Rech Scient Compositions nutritionnelles carencees en methionine destinees a inhiber le developpement et la dissemination des tumeurs malignes chez les mammiferes
US4981687A (en) * 1988-07-29 1991-01-01 University Of Florida Compositions and methods for achieving improved physiological response to exercise
JPH0368514A (ja) * 1989-08-09 1991-03-25 Morishita Pharmaceut Co Ltd 癌用アミノ酸製剤
FR2673812B1 (fr) * 1991-03-13 1994-04-01 Roussel Uclaf Nouvelles compositions destinees a etre utilisees en dietetique et en therapeutique et renfermant une combinaison particuliere de glucides et leurs applications.
JPH04352720A (ja) * 1991-05-30 1992-12-07 Tanabe Seiyaku Co Ltd 癌患者用アミノ酸製剤
ATE183923T1 (de) * 1991-10-07 1999-09-15 Otsuka Pharma Co Ltd Enterale zubereitungen zur krebstherapie
JP3380287B2 (ja) * 1992-04-07 2003-02-24 麒麟麦酒株式会社 血中アルコール濃度上昇阻害飲料
US6338856B1 (en) * 1998-02-27 2002-01-15 Texas Tech University Seaweed supplement diet for enhancing immune response in mammals and poultry
JPH11332514A (ja) * 1998-05-22 1999-12-07 Nof Corp バランス栄養食品
US7115297B2 (en) * 2000-02-22 2006-10-03 Suzanne Jaffe Stillman Nutritionally fortified liquid composition with added value delivery systems/elements/additives
US7744930B2 (en) * 2002-11-22 2010-06-29 Shaklee Corporation Compositions, methods and kits for enhancing weight loss while inhibiting loss of lean body mass
GB0416493D0 (en) * 2004-07-23 2004-08-25 Pitsiladis Yannis P Hydrating composition
EP1731145A1 (en) * 2005-05-25 2006-12-13 Institut National De La Recherche Agronomique Use of glycerol for improving cardiac function
KR20100015922A (ko) * 2007-03-26 2010-02-12 히로후미 마쓰이 암 환자용 수액 제제

Also Published As

Publication number Publication date
WO2009132320A3 (en) 2010-01-07
CA2722365A1 (en) 2009-10-29
EP2285218B1 (en) 2020-06-17
CA3045883A1 (en) 2009-10-29
CA2722365C (en) 2019-08-06
ES2800327T3 (es) 2020-12-29
EP2285218A4 (en) 2011-10-05
EP2285218A2 (en) 2011-02-23
JP2015186480A (ja) 2015-10-29
JP2011523626A (ja) 2011-08-18
WO2009132320A2 (en) 2009-10-29

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