CA3045110A1 - Tyrosine derivatives and compositions comprising them - Google Patents

Info

Publication number

CA3045110A1

CA3045110A1 CA3045110A CA3045110A CA3045110A1 CA 3045110 A1 CA3045110 A1 CA 3045110A1 CA 3045110 A CA3045110 A CA 3045110A CA 3045110 A CA3045110 A CA 3045110A CA 3045110 A1 CA3045110 A1 CA 3045110A1

Authority

CA

Canada

Prior art keywords

cancer

tyrosine

methyl

composition

amino

Prior art date

2016-11-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 239000000203 mixture Substances 0.000 title claims abstract description 75
• 150000003667 tyrosine derivatives Chemical class 0.000 title claims description 26
• 239000002246 antineoplastic agent Substances 0.000 claims abstract description 82
• 229940122110 Tyrosine hydroxylase inhibitor Drugs 0.000 claims abstract description 65
• 238000000034 method Methods 0.000 claims abstract description 36
• 230000004663 cell proliferation Effects 0.000 claims abstract description 14
• 206010028980 Neoplasm Diseases 0.000 claims description 67
• 201000011510 cancer Diseases 0.000 claims description 62
• 239000003814 drug Substances 0.000 claims description 49
• -1 methyl ester hydrochloride Chemical class 0.000 claims description 41
• 229940124597 therapeutic agent Drugs 0.000 claims description 35
• 210000004027 cell Anatomy 0.000 claims description 31
• 239000003112 inhibitor Substances 0.000 claims description 23
• 239000003795 chemical substances by application Substances 0.000 claims description 16
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• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 10
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• VXYFARNRGZWHTJ-SBSPUUFOSA-N hydron;methyl (2r)-2-amino-3-(4-hydroxyphenyl)propanoate;chloride Chemical compound Cl.COC(=O)[C@H](N)CC1=CC=C(O)C=C1 VXYFARNRGZWHTJ-SBSPUUFOSA-N 0.000 claims description 7
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