CA3040173A1 - Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders - Google Patents

Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders Download PDF

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Publication number
CA3040173A1
CA3040173A1 CA3040173A CA3040173A CA3040173A1 CA 3040173 A1 CA3040173 A1 CA 3040173A1 CA 3040173 A CA3040173 A CA 3040173A CA 3040173 A CA3040173 A CA 3040173A CA 3040173 A1 CA3040173 A1 CA 3040173A1
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Prior art keywords
alkyl
optionally substituted
compound
aryl
hydrogen
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CA3040173A
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English (en)
French (fr)
Inventor
Fleur M. FERGUSON
Nathanael S. Gray
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CA3040173A1 publication Critical patent/CA3040173A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3040173A 2016-10-18 2017-10-18 Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders Pending CA3040173A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662409457P 2016-10-18 2016-10-18
US62/409,457 2016-10-18
PCT/US2017/057126 WO2018075608A1 (en) 2016-10-18 2017-10-18 Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders

Publications (1)

Publication Number Publication Date
CA3040173A1 true CA3040173A1 (en) 2018-04-26

Family

ID=62018969

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3040173A Pending CA3040173A1 (en) 2016-10-18 2017-10-18 Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders

Country Status (6)

Country Link
US (1) US11028089B2 (cg-RX-API-DMAC10.html)
EP (1) EP3528814B1 (cg-RX-API-DMAC10.html)
JP (1) JP7086948B2 (cg-RX-API-DMAC10.html)
AU (1) AU2017346845B2 (cg-RX-API-DMAC10.html)
CA (1) CA3040173A1 (cg-RX-API-DMAC10.html)
WO (1) WO2018075608A1 (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017248186B2 (en) * 2016-04-07 2021-10-21 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders
AU2018392805A1 (en) 2017-12-22 2020-05-07 Dana-Farber Cancer Institute, Inc. NEK inhibitors and methods of use
WO2020206608A1 (en) 2019-04-09 2020-10-15 Ranok Therapeutics (Hangzhou) Co., Ltd. Methods and compositions for targeted protein degradation
US20220280530A1 (en) * 2019-08-08 2022-09-08 Anhui Newstar Pharmaceutical Development Co., Ltd. Prevention or treatment of diseases and disorders associated with tissue damage
US12594277B2 (en) 2020-02-14 2026-04-07 Salk Institute For Biological Studies Macrocyclic ULK1/2 inhibitors
CA3171187A1 (en) * 2020-02-14 2021-08-19 Salk Institute For Biological Studies Inhibitors of ulk1/2 and methods of using same
EP4229061A4 (en) * 2020-10-14 2024-09-25 Ranok Therapeutics (Hangzhou) Co. Ltd. METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION
JP2024509864A (ja) * 2021-03-09 2024-03-05 ヤンセン ファーマシューティカ エヌ．ベー． サイクリン依存性キナーゼ７（ｃｄｋ７）阻害剤としての三環式ピリジン
CN115707469B (zh) * 2021-08-19 2024-07-02 首都医科大学附属北京朝阳医院 Dclk1抑制剂和tki在制备肺腺癌药物中的应用
CN114478539B (zh) * 2022-02-09 2024-02-02 中国人民解放军海军军医大学 一种新型dclk1抑制剂及其制备方法和应用
CN115969978A (zh) * 2022-10-27 2023-04-18 首都医科大学附属北京朝阳医院 Dclk1及il6/stat3通路抑制剂在治疗三阴性乳腺癌中的应用
CN115814094B (zh) * 2023-01-04 2024-04-02 暨南大学附属第一医院（广州华侨医院） Dclk抑制剂在制备治疗脊髓损伤的药物中的应用
CN116375713B (zh) * 2023-03-07 2024-11-19 中国人民解放军海军军医大学 一种dclk1蛋白降解靶向嵌合体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2379559B1 (en) * 2009-01-06 2017-10-25 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
ES2693152T3 (es) * 2011-05-10 2018-12-07 Kyowa Hakko Kirin Co., Ltd. Compuesto de pirimido-diazepinona
WO2014160430A1 (en) * 2013-03-13 2014-10-02 Georgetown University Small molecule lrrk2 and erk5 inhibitors
EP2970317A4 (en) * 2013-03-15 2016-11-02 Dana Farber Cancer Inst Inc PYRIMIDODIAZEPINONE COMPOUNDS AND METHOD FOR THE TREATMENT OF DISEASES
EP3099693A4 (en) * 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
WO2015117083A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
RU2017104897A (ru) * 2014-08-08 2018-09-10 Дана-Фарбер Кэнсер Инститьют, Инк. Производные диазепана и их применения
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
JP6815318B2 (ja) * 2014-12-23 2021-01-20 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 二官能性分子によって標的化タンパク質分解を誘導する方法
JP2019512459A (ja) * 2016-03-04 2019-05-16 アンホイ ニュー スター ファーマシューティカル デベロップメント カンパニー，リミテッド ７員環化合物、その調製方法、その医薬組成物、およびその使用

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Publication number Publication date
US20190315753A1 (en) 2019-10-17
JP2019530724A (ja) 2019-10-24
EP3528814A4 (en) 2020-07-29
EP3528814A1 (en) 2019-08-28
US11028089B2 (en) 2021-06-08
AU2017346845B2 (en) 2021-12-02
AU2017346845A1 (en) 2019-04-04
EP3528814B1 (en) 2024-08-14
JP7086948B2 (ja) 2022-06-20
WO2018075608A1 (en) 2018-04-26

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