CA3039136A1 - Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments - Google Patents
Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments Download PDFInfo
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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| PCT/IB2017/055281 WO2018042385A2 (en) | 2016-09-02 | 2017-09-01 | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
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| US11253546B2 (en) | 2014-12-15 | 2022-02-22 | The Regents Of The University Of California | Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20 |
| HK1255383A1 (zh) | 2015-07-31 | 2019-08-16 | The Research Institute At Nationwide Children's Hospital | 去除生物膜的肽及抗體 |
| CN108148863B (zh) * | 2016-12-05 | 2019-12-17 | 上海优卡迪生物医药科技有限公司 | 一种封闭il6r的用于缓解crs的car-t转基因载体及其构建方法和应用 |
| EP3565589A1 (en) | 2017-01-04 | 2019-11-13 | Research Institute at Nationwide Children's Hospital | Dnabii vaccines and antibodies with enhanced activity |
| WO2018129092A1 (en) | 2017-01-04 | 2018-07-12 | Research Institute At Nationwide Children's Hospital | Antibody fragments for the treatment of biofilm-related disorders |
| EP4491718A3 (en) * | 2018-03-14 | 2025-03-26 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy |
| WO2019178259A2 (en) | 2018-03-14 | 2019-09-19 | Celledit Llc | Modification of immune cells for reducing toxicity and uses thereof in adoptive cell therapy |
| EP3860718A4 (en) | 2018-10-05 | 2022-08-31 | Research Institute at Nationwide Children's Hospital | HMGB1 PROTEIN DERIVATIVES FOR BIOFILM REMOVAL |
| WO2020146239A1 (en) * | 2019-01-07 | 2020-07-16 | Celledit Llc | Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy |
| JP2022534513A (ja) * | 2019-05-31 | 2022-08-01 | ザ・ジョンズ・ホプキンス・ユニバーシティー | がん細胞遊走を阻害するためのＩＬ－６Ｒα／ＩＬ－８Ｒ二重特異性結合剤 |
| GB2599814A (en) | 2019-05-31 | 2022-04-13 | Univ Johns Hopkins | Bispecific binding agents |
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| JP2025521543A (ja) * | 2022-06-22 | 2025-07-10 | ジュノー セラピューティクス インコーポレイテッド | Ｃｄ１９標的ｃａｒ ｔ細胞のセカンドライン治療のための処置方法 |
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| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| US20130280220A1 (en) | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| JP6306596B2 (ja) | 2012-10-04 | 2018-04-04 | リサーチ ディベロップメント ファウンデーション | セリンプロテアーゼ分子および療法 |
| EP2730289A1 (en) | 2012-11-07 | 2014-05-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Novel immunoproteases |
| PL2922872T3 (pl) | 2012-11-21 | 2019-03-29 | Janssen Biotech, Inc. | Bispecyficzne przeciwciała przeciwko egfr/c-met |
| KR102258457B1 (ko) | 2013-03-11 | 2021-05-31 | 젠자임 코포레이션 | 조작된 항-tgf-베타 항체 및 항원-결합 단편 |
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| HK1243441A1 (zh) | 2014-11-05 | 2018-07-13 | Board Of Regents, The University Of Texas System | 基因修饰的免疫效应细胞和用於扩增免疫效应细胞的工程化细胞 |
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| US10647778B2 (en) | 2015-02-09 | 2020-05-12 | University Of Florida Research Foundation, Incorporated | Bi-specific chimeric antigen receptor and uses thereof |
| RS64053B1 (sr) | 2015-10-30 | 2023-04-28 | Univ California | Polipeptidi koji reaguju na transformišući faktor rasta – beta i postupci za njihovu upotrebu |
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| AU2017244108B2 (en) | 2016-03-29 | 2021-03-18 | University Of Southern California | Chimeric antigen receptors targeting cancer |
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| EP4353750A3 (en) | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| CA3044682A1 (en) | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| CN108148863B (zh) * | 2016-12-05 | 2019-12-17 | 上海优卡迪生物医药科技有限公司 | 一种封闭il6r的用于缓解crs的car-t转基因载体及其构建方法和应用 |
| SG11202000555UA (en) | 2017-06-21 | 2020-02-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
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2017
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- 2017-09-01 CN CN201780067444.9A patent/CN109963590B/zh active Active
- 2017-09-01 US US16/329,367 patent/US11701384B2/en active Active
- 2017-09-01 AU AU2017319702A patent/AU2017319702B2/en active Active
- 2017-09-01 CA CA3039136A patent/CA3039136A1/en active Pending
- 2017-09-01 EP EP17845645.5A patent/EP3506943B1/en active Active
- 2017-09-01 WO PCT/IB2017/055281 patent/WO2018042385A2/en not_active Ceased
- 2017-09-01 KR KR1020197009353A patent/KR20190057308A/ko not_active Withdrawn
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2023
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| AU2017319702A1 (en) | 2019-04-11 |
| WO2018042385A2 (en) | 2018-03-08 |
| EP3506943B1 (en) | 2025-01-29 |
| EP3506943A4 (en) | 2020-04-22 |
| US20200179448A1 (en) | 2020-06-11 |
| US11701384B2 (en) | 2023-07-18 |
| CN109963590B (zh) | 2024-03-15 |
| CN109963590A (zh) | 2019-07-02 |
| EP3506943A2 (en) | 2019-07-10 |
| JP2019530440A (ja) | 2019-10-24 |
| AU2017319702B2 (en) | 2024-11-14 |
| WO2018042385A3 (en) | 2018-04-19 |
| US20230372400A1 (en) | 2023-11-23 |
| KR20190057308A (ko) | 2019-05-28 |
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