CA3034470A1 - Avibactam free acid - Google Patents

Avibactam free acid Download PDF

Info

Publication number
CA3034470A1
CA3034470A1 CA3034470A CA3034470A CA3034470A1 CA 3034470 A1 CA3034470 A1 CA 3034470A1 CA 3034470 A CA3034470 A CA 3034470A CA 3034470 A CA3034470 A CA 3034470A CA 3034470 A1 CA3034470 A1 CA 3034470A1
Authority
CA
Canada
Prior art keywords
avibactam
formula
oxo
diazabicylco
octan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3034470A
Other languages
English (en)
French (fr)
Inventor
Michael Fischer
Andreas Lechner
Brigitte STAGGL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of CA3034470A1 publication Critical patent/CA3034470A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3034470A 2016-08-26 2017-08-25 Avibactam free acid Abandoned CA3034470A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16185913 2016-08-26
EP16185913.7 2016-08-26
PCT/EP2017/071471 WO2018037124A1 (en) 2016-08-26 2017-08-25 Avibactam free acid

Publications (1)

Publication Number Publication Date
CA3034470A1 true CA3034470A1 (en) 2018-03-01

Family

ID=56802364

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034470A Abandoned CA3034470A1 (en) 2016-08-26 2017-08-25 Avibactam free acid

Country Status (8)

Country Link
US (1) US11124513B2 (enExample)
EP (1) EP3504207B1 (enExample)
JP (1) JP7183147B2 (enExample)
KR (1) KR102482826B1 (enExample)
CN (1) CN109641901B (enExample)
AU (1) AU2017315164B2 (enExample)
CA (1) CA3034470A1 (enExample)
WO (1) WO2018037124A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018146134A1 (en) 2017-02-08 2018-08-16 Sandoz Ag Process for the preparation of crystalline form c of avibactam sodium
CN113105455B (zh) * 2020-01-10 2024-05-17 四川科伦药物研究院有限公司 晶型b阿维巴坦钠的制备方法
CN115677697B (zh) * 2022-09-19 2024-08-06 瑞阳制药股份有限公司 粒度可调控且流动性好的b晶型阿维巴坦钠析晶方法
CN117603207A (zh) * 2023-10-23 2024-02-27 江西富祥药业股份有限公司 一种阿维巴坦钠中间体的纯化方法及阿维巴坦钠中间体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2951171A1 (fr) * 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
US8829191B2 (en) * 2011-06-17 2014-09-09 Melanie Simone Ronsheim Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
AU2013380573B2 (en) 2013-03-08 2016-07-07 Wockhardt Limited A process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
WO2016046845A1 (en) * 2014-09-25 2016-03-31 Manu Chaudhary Stealth, targeted nanoparticles (stn) for oral drug delivery
EP3334734B1 (en) 2015-08-10 2020-01-01 Sandoz AG Form c of avibactam sodium
CN106699756B (zh) 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法

Also Published As

Publication number Publication date
US20190185473A1 (en) 2019-06-20
JP2019524829A (ja) 2019-09-05
US11124513B2 (en) 2021-09-21
EP3504207B1 (en) 2022-06-01
KR20190040988A (ko) 2019-04-19
WO2018037124A1 (en) 2018-03-01
CN109641901B (zh) 2022-12-09
AU2017315164A1 (en) 2019-02-28
EP3504207A1 (en) 2019-07-03
AU2017315164B2 (en) 2021-12-09
KR102482826B1 (ko) 2022-12-28
CN109641901A (zh) 2019-04-16
JP7183147B2 (ja) 2022-12-05

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20230227