CA3032596A1 - Anti-cd3 antibody formulations - Google Patents
Anti-cd3 antibody formulations Download PDFInfo
- Publication number
- CA3032596A1 CA3032596A1 CA3032596A CA3032596A CA3032596A1 CA 3032596 A1 CA3032596 A1 CA 3032596A1 CA 3032596 A CA3032596 A CA 3032596A CA 3032596 A CA3032596 A CA 3032596A CA 3032596 A1 CA3032596 A1 CA 3032596A1
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- antibody
- formulations
- trehalose
- antigen binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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| Application Number | Priority Date | Filing Date | Title |
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| US201662380652P | 2016-08-29 | 2016-08-29 | |
| US62/380,652 | 2016-08-29 | ||
| PCT/US2017/049211 WO2018044948A1 (en) | 2016-08-29 | 2017-08-29 | Anti-cd3 antibody formulations |
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| CA3032596A1 true CA3032596A1 (en) | 2018-03-08 |
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| EP (2) | EP4406554A3 (enExample) |
| JP (3) | JP7057360B2 (enExample) |
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| IL (2) | IL301948B2 (enExample) |
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| IL301948B2 (en) | 2016-08-29 | 2024-09-01 | Tiziana Life Sciences Plc | Anti-cd3 antibody formulations |
| US20200165338A1 (en) * | 2017-06-06 | 2020-05-28 | The Brigham And Women`S Hospital, Inc. | Methods of suppressing microglial activation |
| EP3488851A1 (en) * | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
| EP3863621A4 (en) * | 2018-10-09 | 2022-08-24 | Monash University | COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF AUTOIMMUNE AND INFLAMMATION DISEASES |
| WO2020089396A2 (en) | 2018-10-31 | 2020-05-07 | Tiziana Life Sciences Plc | Composition and methods of treating inflammatory and autoimmune diseases |
| KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| WO2021035054A1 (en) | 2019-08-20 | 2021-02-25 | Precision Biosciences, Inc. | Lymphodepletion dosing regimens for cellular immunotherapies |
| US20210284743A1 (en) * | 2020-03-10 | 2021-09-16 | Tiziana Life Sciences Plc | Compositions of il-6/il-6r antibodies and methods of use thereof |
| GB2595299B (en) | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| WO2022023566A2 (en) * | 2020-07-30 | 2022-02-03 | Tiziana Life Sciences Plc | Cd-3 antibodies for the treatment of coronavirus |
| CA3187690A1 (en) * | 2020-07-31 | 2022-02-03 | Jane Elizabeth Clarkson | Antigen binding protein |
| EP4323404A1 (en) * | 2021-04-16 | 2024-02-21 | Tiziana Life Sciences PLC | Subcutaneous administration of antibodies for the treatment of disease |
| AU2023269309A1 (en) * | 2022-05-13 | 2024-11-07 | Tiziana Life Sciences Plc | Nasal formulations of foralumab |
| KR20250044334A (ko) * | 2022-07-27 | 2025-03-31 | 셀덱스 쎄라퓨틱스, 인크. | 항-kit 항체 제형 및 방법 |
| CN120112292A (zh) | 2022-09-09 | 2025-06-06 | 爱杜西亚药品有限公司 | 包含抗-cd3抗体及cxcr3拮抗剂的药物组合 |
| WO2024165671A1 (en) | 2023-02-08 | 2024-08-15 | Immunos Therapeutics Ag | FUSION PROTEINS OF ß2 MICROGLOBULIN, HLA HEAVY CHAIN POLYPEPTIDES, AND INHIBITOR OF CD47-SIRPA |
| WO2024182767A1 (en) | 2023-03-01 | 2024-09-06 | Provention Bio, Inc. | Methods and compositions for treating type 1 diabetes comprising teplizumab and verapamil |
| TW202502380A (zh) * | 2023-03-16 | 2025-01-16 | 日商小野藥品工業股份有限公司 | 抗體製劑 |
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| US20030235583A1 (en) | 2002-06-14 | 2003-12-25 | Jeppe Sturis | Combined use of a modulator of CD3 and a beta cell resting compound |
| US20040037826A1 (en) | 2002-06-14 | 2004-02-26 | Michelsen Birgitte Koch | Combined use of a modulator of CD3 and a GLP-1 compound |
| DK1687066T3 (da) * | 2003-11-14 | 2012-11-26 | Brigham & Womens Hospital | Fremgangsmåder til immunmodulering |
| WO2007033230A2 (en) | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-cd3 antibody formulations |
| WO2007092772A2 (en) * | 2006-02-03 | 2007-08-16 | Medimmune, Inc. | Protein formulations |
| EP2007423A2 (en) | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Ctla4 antibody combination therapy |
| EP2225275A4 (en) | 2007-11-28 | 2013-04-03 | Medimmune Llc | PROTEIN FORMULATION |
| MX2011003133A (es) * | 2008-09-26 | 2011-04-21 | Roche Glycart Ag | Anticuerpos biespecificos anti-egfr/anti-igf-1r. |
| KR20120027031A (ko) * | 2009-06-18 | 2012-03-20 | 와이어쓰 엘엘씨 | 소형 모듈 면역제약용 동결건조 제제 |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| US20130171142A1 (en) * | 2009-10-20 | 2013-07-04 | Aoife Brennan | Methods of using anti-cd3 antibodies to prevent weight gain |
| US20120269826A1 (en) * | 2009-10-20 | 2012-10-25 | Mckee Charlotte | Anti-cd3 antibody dosing in autoimmune disease |
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| US20120189621A1 (en) * | 2011-01-21 | 2012-07-26 | Yann Dean | Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists |
| UA118028C2 (uk) * | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| IL301948B2 (en) | 2016-08-29 | 2024-09-01 | Tiziana Life Sciences Plc | Anti-cd3 antibody formulations |
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Also Published As
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| US20180177880A1 (en) | 2018-06-28 |
| EP4406554A2 (en) | 2024-07-31 |
| CN109843920B (zh) | 2023-01-13 |
| AU2017319318B2 (en) | 2024-09-19 |
| EP3504241A1 (en) | 2019-07-03 |
| IL301948B2 (en) | 2024-09-01 |
| JP7461401B2 (ja) | 2024-04-03 |
| JP2022082757A (ja) | 2022-06-02 |
| AU2017319318A1 (en) | 2019-02-21 |
| EP4406554A3 (en) | 2024-10-30 |
| JP2019526627A (ja) | 2019-09-19 |
| WO2018044948A1 (en) | 2018-03-08 |
| DK3504241T3 (da) | 2024-08-19 |
| IL264502B1 (en) | 2023-05-01 |
| ES2986900T3 (es) | 2024-11-13 |
| US20250228946A1 (en) | 2025-07-17 |
| IL264502B2 (en) | 2023-09-01 |
| CN109843920A (zh) | 2019-06-04 |
| CN116617387A (zh) | 2023-08-22 |
| IL301948A (en) | 2023-06-01 |
| AU2024278457A1 (en) | 2025-01-09 |
| US10688186B2 (en) | 2020-06-23 |
| IL301948B1 (en) | 2024-05-01 |
| EP3504241B1 (en) | 2024-05-15 |
| JP7057360B2 (ja) | 2022-04-19 |
| JP2024075713A (ja) | 2024-06-04 |
| US20210000957A1 (en) | 2021-01-07 |
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