CA3030021A1 - Methods for treatment of heart failure - Google Patents
Methods for treatment of heart failure Download PDFInfo
- Publication number
- CA3030021A1 CA3030021A1 CA3030021A CA3030021A CA3030021A1 CA 3030021 A1 CA3030021 A1 CA 3030021A1 CA 3030021 A CA3030021 A CA 3030021A CA 3030021 A CA3030021 A CA 3030021A CA 3030021 A1 CA3030021 A1 CA 3030021A1
- Authority
- CA
- Canada
- Prior art keywords
- oxo
- carboxylic acid
- alkyl
- dihydrothieno
- heart failure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003577 thiophenes Chemical class 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229960002051 trandolapril Drugs 0.000 description 1
- 238000010967 transthoracic echocardiography Methods 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000012762 unpaired Student’s t-test Methods 0.000 description 1
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
- 229940099270 vasotec Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940052204 zebeta Drugs 0.000 description 1
- 229940072252 zestril Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359695P | 2016-07-07 | 2016-07-07 | |
| US62/359,695 | 2016-07-07 | ||
| PCT/US2017/041249 WO2018009899A1 (en) | 2016-07-07 | 2017-07-07 | Methods for treatment of heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3030021A1 true CA3030021A1 (en) | 2018-01-11 |
Family
ID=60912319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3030021A Abandoned CA3030021A1 (en) | 2016-07-07 | 2017-07-07 | Methods for treatment of heart failure |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10870656B2 (enExample) |
| EP (1) | EP3481399A4 (enExample) |
| JP (1) | JP2019521192A (enExample) |
| KR (1) | KR20190049691A (enExample) |
| AU (1) | AU2017292918B2 (enExample) |
| CA (1) | CA3030021A1 (enExample) |
| WO (1) | WO2018009899A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10822346B2 (en) * | 2018-04-17 | 2020-11-03 | Cardurion Pharmaceuticals, Llc | Meglumine salts of thienopyrimidines |
| TWI816026B (zh) * | 2019-03-08 | 2023-09-21 | 大陸商藥捷安康(南京)科技股份有限公司 | 磷酸二酯酶抑制劑的用途和藥盒 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| JP5070052B2 (ja) * | 2004-08-17 | 2012-11-07 | ザ・ジョンズ・ホプキンス・ユニバーシティ | Ｐｄｅ５阻害剤組成物及び心臓疾患を治療する方法 |
| CN101198614B (zh) * | 2005-06-14 | 2011-07-06 | Aska制药株式会社 | 噻吩并嘧啶衍生物 |
| PL2041139T3 (pl) * | 2006-04-26 | 2012-05-31 | Hoffmann La Roche | Związki farmaceutyczne |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| WO2011152411A1 (ja) * | 2010-05-31 | 2011-12-08 | あすか製薬株式会社 | チエノピリミジン誘導体の結晶 |
| EA201600318A1 (ru) * | 2013-10-07 | 2016-09-30 | Байер Фарма Акциенгезельшафт | Циклические тиеноурацилкарбоксамиды и их применение |
-
2017
- 2017-07-07 WO PCT/US2017/041249 patent/WO2018009899A1/en not_active Ceased
- 2017-07-07 JP JP2019520937A patent/JP2019521192A/ja active Pending
- 2017-07-07 CA CA3030021A patent/CA3030021A1/en not_active Abandoned
- 2017-07-07 KR KR1020197003599A patent/KR20190049691A/ko not_active Ceased
- 2017-07-07 EP EP17825050.2A patent/EP3481399A4/en not_active Withdrawn
- 2017-07-07 AU AU2017292918A patent/AU2017292918B2/en active Active
-
2019
- 2019-01-04 US US16/240,393 patent/US10870656B2/en active Active
-
2020
- 2020-12-21 US US17/128,584 patent/US20210261567A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3481399A1 (en) | 2019-05-15 |
| AU2017292918B2 (en) | 2021-11-11 |
| JP2019521192A (ja) | 2019-07-25 |
| US10870656B2 (en) | 2020-12-22 |
| KR20190049691A (ko) | 2019-05-09 |
| EP3481399A4 (en) | 2020-04-01 |
| US20190211028A1 (en) | 2019-07-11 |
| WO2018009899A1 (en) | 2018-01-11 |
| AU2017292918A1 (en) | 2019-02-07 |
| US20210261567A1 (en) | 2021-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20231004 |