CA3029333A1 - Solid forms of an sgc stimulator - Google Patents

Solid forms of an sgc stimulator Download PDF

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Publication number
CA3029333A1
CA3029333A1 CA3029333A CA3029333A CA3029333A1 CA 3029333 A1 CA3029333 A1 CA 3029333A1 CA 3029333 A CA3029333 A CA 3029333A CA 3029333 A CA3029333 A CA 3029333A CA 3029333 A1 CA3029333 A1 CA 3029333A1
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CA
Canada
Prior art keywords
compound
disease
crystalline free
diseases
free form
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Application number
CA3029333A
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English (en)
French (fr)
Other versions
CA3029333C (en
Inventor
Vasu SETHURAMAN
Ahmad Hashash
Song Xue
Robert C. Livingston
Kwame Wiredu NTI-ADDAE
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Cyclerion Therapeutics Inc
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Ironwood Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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