CA3026770C - Andrographolide treats progressive forms of multiple sclerosis - Google Patents

Andrographolide treats progressive forms of multiple sclerosis Download PDF

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Publication number
CA3026770C
CA3026770C CA3026770A CA3026770A CA3026770C CA 3026770 C CA3026770 C CA 3026770C CA 3026770 A CA3026770 A CA 3026770A CA 3026770 A CA3026770 A CA 3026770A CA 3026770 C CA3026770 C CA 3026770C
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CA
Canada
Prior art keywords
group
multiple sclerosis
progressive
andrographolide
oral dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3026770A
Other languages
English (en)
French (fr)
Other versions
CA3026770A1 (en
Inventor
Juan O. Hancke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INNOBIOSCIENCE LLC
Original Assignee
INNOBIOSCIENCE LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INNOBIOSCIENCE LLC filed Critical INNOBIOSCIENCE LLC
Publication of CA3026770A1 publication Critical patent/CA3026770A1/en
Application granted granted Critical
Publication of CA3026770C publication Critical patent/CA3026770C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3026770A 2016-06-08 2017-06-08 Andrographolide treats progressive forms of multiple sclerosis Active CA3026770C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662347218P 2016-06-08 2016-06-08
US62/347,218 2016-06-08
PCT/US2017/036463 WO2017214346A1 (en) 2016-06-08 2017-06-08 Andrographolide treats progressive forms of multiple sclerosis

Publications (2)

Publication Number Publication Date
CA3026770A1 CA3026770A1 (en) 2017-12-14
CA3026770C true CA3026770C (en) 2024-05-28

Family

ID=60578163

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3026770A Active CA3026770C (en) 2016-06-08 2017-06-08 Andrographolide treats progressive forms of multiple sclerosis

Country Status (8)

Country Link
US (1) US10722492B2 (https=)
EP (1) EP3468553B1 (https=)
JP (2) JP6928963B2 (https=)
CN (1) CN109562097B (https=)
CA (1) CA3026770C (https=)
DK (1) DK3468553T3 (https=)
MX (1) MX386393B (https=)
WO (1) WO2017214346A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019126759A1 (en) * 2017-12-22 2019-06-27 Convelo Therapeutics, Inc. Compounds and methods of promoting myelination
CN109293607A (zh) * 2018-11-14 2019-02-01 株洲千金药业股份有限公司 一种具有抗炎作用的化合物及其在制备抗炎药物中的应用
CN109223770A (zh) * 2018-11-14 2019-01-18 株洲千金药业股份有限公司 一种具有镇痛作用的化合物及其在制备镇痛药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1455826A2 (en) * 2001-12-21 2004-09-15 Ilex Oncology, Inc. Combination comprising anti-cd52 antibodies and other therapeutic agents for treatment of multiple sclerosis
CN1921872A (zh) * 2004-02-03 2007-02-28 智利南方大学 用于激活PPR－γ受体而治疗自身免疫性疾病和阿尔茨海默病的提取自穿心莲的半日花烷型二萜类组合物
US9060994B2 (en) * 2011-12-21 2015-06-23 Inno Biosciences, S.p.A. Combination therapy with interferon and andrographolides for Multiple Sclerosis

Also Published As

Publication number Publication date
EP3468553A1 (en) 2019-04-17
US20190083458A1 (en) 2019-03-21
JP2021165304A (ja) 2021-10-14
EP3468553A4 (en) 2020-02-12
CN109562097A (zh) 2019-04-02
JP2019517550A (ja) 2019-06-24
CN109562097B (zh) 2022-06-07
CA3026770A1 (en) 2017-12-14
DK3468553T3 (da) 2023-07-03
US10722492B2 (en) 2020-07-28
WO2017214346A1 (en) 2017-12-14
MX386393B (es) 2025-03-18
JP6928963B2 (ja) 2021-09-01
EP3468553B1 (en) 2023-05-24
MX2018015208A (es) 2019-09-19

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