CA3026396A1 - Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide - Google Patents

Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide Download PDF

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Publication number
CA3026396A1
CA3026396A1 CA3026396A CA3026396A CA3026396A1 CA 3026396 A1 CA3026396 A1 CA 3026396A1 CA 3026396 A CA3026396 A CA 3026396A CA 3026396 A CA3026396 A CA 3026396A CA 3026396 A1 CA3026396 A1 CA 3026396A1
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CA
Canada
Prior art keywords
compound
administered
subject
days
aml
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3026396A
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English (en)
French (fr)
Inventor
Soraya Carrancio
Paul Hollenbach
Antonia Lopez-Girona
Kyle Macbeth
Michael POURDEHNAD
Irit Rappley
Lu Gang
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Celgene Corp
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Celgene Corp
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Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CA3026396A1 publication Critical patent/CA3026396A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3026396A 2016-06-06 2017-06-05 Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide Pending CA3026396A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662346344P 2016-06-06 2016-06-06
US62/346,344 2016-06-06
PCT/US2017/035892 WO2017214014A1 (en) 2016-06-06 2017-06-05 Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Publications (1)

Publication Number Publication Date
CA3026396A1 true CA3026396A1 (en) 2017-12-14

Family

ID=60482040

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3026396A Pending CA3026396A1 (en) 2016-06-06 2017-06-05 Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Country Status (15)

Country Link
US (4) US10245258B2 (enExample)
EP (1) EP3463358A4 (enExample)
JP (1) JP7163281B2 (enExample)
KR (1) KR20190015300A (enExample)
CN (2) CN109414436A (enExample)
AU (2) AU2017278114B2 (enExample)
BR (1) BR112018075206A2 (enExample)
CA (1) CA3026396A1 (enExample)
CL (1) CL2018003499A1 (enExample)
EA (1) EA201892746A1 (enExample)
IL (1) IL262565B (enExample)
MX (1) MX388717B (enExample)
SG (1) SG11201809501PA (enExample)
WO (1) WO2017214014A1 (enExample)
ZA (1) ZA201807105B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
WO2017120446A1 (en) 2016-01-08 2017-07-13 Celgene Corporation Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies
US11535603B1 (en) 2016-09-30 2022-12-27 Deuterx, Llc Deuterium-enriched piperidinonyl-oxoisoindolinyl acetamides and methods of treating medical disorders using same
CN118834201A (zh) 2016-12-01 2024-10-25 阿尔维纳斯运营股份有限公司 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物
CA3125189A1 (en) * 2018-12-31 2020-07-09 Celgene Corporation Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5yl) methyl)-2,2-difluoroacetamide
IL290789B2 (en) 2019-08-26 2025-09-01 Arvinas Operations Inc Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents
US11583536B2 (en) 2019-10-21 2023-02-21 Celgene Corporation Substituted 4-aminoisoindoline-1,3-dione compounds and second active agents for combined use
AU2020379680A1 (en) * 2019-11-05 2022-05-26 Celgene Corporation Combination therapy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide
AU2020396543A1 (en) 2019-12-06 2022-06-16 Celgene Corporation Processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
MX2022011523A (es) * 2020-03-16 2022-12-13 Celgene Corp Terapia combinada para leucemia mielógena aguda.
KR20230069144A (ko) * 2020-09-14 2023-05-18 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체의 표적화된 분해를 위한 화합물의 결정질 형태
PE20230847A1 (es) 2020-09-23 2023-05-23 St Jude Childrens Res Hospital Inc Analogos de n-(2-(2,6-dioxopiperidin-3-il)-1,3-dioxoisoindolin-5-il)arilsufonamida sustituidos como modulares de la proteina cereblon
KR20240066906A (ko) * 2022-11-08 2024-05-16 주식회사 온코드바이오 퀴놀린 아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04005260A (es) * 2001-12-03 2005-03-23 Novacea Inc Composiciones farmaceuticas que comprenden compuestos activos de vitamina d.
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US20090175869A1 (en) 2007-05-31 2009-07-09 Ascenta Therapeutics, Inc. Pulsatile Dosing of Gossypol for Treatment of Disease
JP2012527424A (ja) 2009-05-20 2012-11-08 イブリジェニク ソシエテ アノニム イネカルシトールの新しい治療的使用
BR112014010417A2 (pt) * 2011-11-01 2014-11-18 Celgene Corp Métodos para o tratamento de cânceres com o uso de formulações orais de análogos de citidina
WO2015082384A1 (en) 2013-12-05 2015-06-11 F. Hoffmann-La Roche Ag Novel combination treatment for acute myeloid leukemia (aml)
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
WO2017120415A1 (en) 2016-01-08 2017-07-13 Celgene Corporation Solid forms of 2-(4-chlorophenyl)-n-((2-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses
CN108601777B (zh) 2016-01-08 2021-08-03 细胞基因公司 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂
BR112018013761A2 (pt) 2016-01-08 2018-12-11 Celgene Corp compostos antiproliferativos e suas composições farmacêuticas e usos

Also Published As

Publication number Publication date
SG11201809501PA (en) 2018-12-28
IL262565A (en) 2018-12-31
EA201892746A1 (ru) 2019-06-28
CL2018003499A1 (es) 2019-03-15
BR112018075206A2 (pt) 2019-03-19
EP3463358A1 (en) 2019-04-10
US10245258B2 (en) 2019-04-02
ZA201807105B (en) 2020-01-29
JP2019517587A (ja) 2019-06-24
JP7163281B2 (ja) 2022-10-31
IL262565B (en) 2022-08-01
EP3463358A4 (en) 2020-07-22
WO2017214014A1 (en) 2017-12-14
KR20190015300A (ko) 2019-02-13
AU2023202159A1 (en) 2023-05-04
US20230158009A1 (en) 2023-05-25
US20170348298A1 (en) 2017-12-07
AU2017278114A1 (en) 2018-11-29
US11590117B2 (en) 2023-02-28
MX2018015120A (es) 2019-04-15
CN115282149A (zh) 2022-11-04
US20190175573A1 (en) 2019-06-13
MX388717B (es) 2025-03-20
US20210154182A1 (en) 2021-05-27
CN109414436A (zh) 2019-03-01
AU2017278114B2 (en) 2023-01-12

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