CA3024482A1 - Derives d'indole macrocycliques - Google Patents

Derives d'indole macrocycliques Download PDF

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Publication number
CA3024482A1
CA3024482A1 CA3024482A CA3024482A CA3024482A1 CA 3024482 A1 CA3024482 A1 CA 3024482A1 CA 3024482 A CA3024482 A CA 3024482A CA 3024482 A CA3024482 A CA 3024482A CA 3024482 A1 CA3024482 A1 CA 3024482A1
Authority
CA
Canada
Prior art keywords
group
alkylene
alkyl
indole
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3024482A
Other languages
English (en)
Inventor
Sarah Anna Liesa Johannes
Philipp BUCHGRABER
Ulrich Klar
Clara CHRIST
Amaury Ernesto FERNANDEZ-MONTALVAN
Manfred Mowes
Philip Lienau
Knut Eis
Ulrike SACK
Ursula Monning
Arne Scholz
Joachim Kuhnke
Kai Thede
Nicolas WERBECK
Michael H. Serrano-Wu
Chris LEMKE
David Mckinney
Mark Fitzgerald
Christopher NASVESCHUK
Kiel LAZARSKI
Steven James Ferrara
Laura FURST
Guo Wei
Patrick Ryan Mccarren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Pharma AG
Broad Institute Inc
Original Assignee
Bayer AG
Bayer Pharma AG
Broad Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Pharma AG, Broad Institute Inc filed Critical Bayer AG
Publication of CA3024482A1 publication Critical patent/CA3024482A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des composés indole macrocycliques de formule générale (I) : (I) dans laquelle R1, R2, R3, R4, R5, R6, A et L sont tels que définis dans la description, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions et combinaisons pharmaceutiques comprenant lesdits composés, et l'utilisation desdits composés pour la fabrication de compositions pharmaceutiques pour le traitement ou la prophylaxie de maladies, en particulier de maladies hyperprolifératives et/ou inflammatoires, en monothérapie ou en association avec d'autres principes actifs.
CA3024482A 2016-05-19 2017-05-17 Derives d'indole macrocycliques Pending CA3024482A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662338942P 2016-05-19 2016-05-19
US62/338,942 2016-05-19
EP16172726 2016-06-02
EP16172726.8 2016-06-02
PCT/EP2017/000629 WO2017198341A1 (fr) 2016-05-19 2017-05-17 Dérivés d'indole macrocycliques

Publications (1)

Publication Number Publication Date
CA3024482A1 true CA3024482A1 (fr) 2017-11-23

Family

ID=56098125

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3024482A Pending CA3024482A1 (fr) 2016-05-19 2017-05-17 Derives d'indole macrocycliques

Country Status (4)

Country Link
CA (1) CA3024482A1 (fr)
TW (1) TW201808957A (fr)
UY (1) UY37250A (fr)
WO (1) WO2017198341A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981932B2 (en) 2016-05-19 2021-04-20 Bayer Aktiengesellschaft Macrocyclic indole derivatives
EP3710456B1 (fr) * 2017-11-17 2022-09-21 The Broad Institute, Inc. Dérivés d'indole macrocycliques
WO2019096907A1 (fr) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Dérivés d'indole macrocycliques annelés aryle
EP3710451A1 (fr) * 2017-11-17 2020-09-23 Bayer Aktiengesellschaft Dérivés d'indole macrocycliques substitués
US11286263B2 (en) 2017-11-17 2022-03-29 The Broad Institute, Inc. Macrocyclic fluorine substituted indole derivatives
EP3710450A1 (fr) 2017-11-17 2020-09-23 Bayer Aktiengesellschaft Dérivés d'indole macrocycliques substitués par du chlore
WO2019096905A1 (fr) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Dérivés d'indole substitués par du chlore macrocyclique
WO2020236556A1 (fr) * 2019-05-17 2020-11-26 The Broad Institute, Inc. Procédés de préparation d'indoles macrocycliques
US11964978B2 (en) 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335564A (ja) 2000-05-26 2001-12-04 Ube Ind Ltd １−アルキル−５−置換ピラゾール−３−カルボン酸エステルの製造法
JP5496876B2 (ja) 2007-04-16 2014-05-21 アッヴィ・インコーポレイテッド ７−置換されていないインドール系Ｍｃｌ−１阻害薬
EP2675440B1 (fr) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Inhibiteurs de cystéine protéases, les cathepsines
WO2015031608A1 (fr) * 2013-08-28 2015-03-05 Vanderbilt University Inhibiteurs de mcl-1 de type indole substitué
US10533010B2 (en) 2014-03-27 2020-01-14 Vanderbilt University Substituted indole Mcl-1 inhibitors
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof

Also Published As

Publication number Publication date
TW201808957A (zh) 2018-03-16
UY37250A (es) 2018-01-02
WO2017198341A1 (fr) 2017-11-23
WO2017198341A8 (fr) 2019-01-03

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