CA3020543A1 - Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use - Google Patents

Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use Download PDF

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Publication number
CA3020543A1
CA3020543A1 CA3020543A CA3020543A CA3020543A1 CA 3020543 A1 CA3020543 A1 CA 3020543A1 CA 3020543 A CA3020543 A CA 3020543A CA 3020543 A CA3020543 A CA 3020543A CA 3020543 A1 CA3020543 A1 CA 3020543A1
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Prior art keywords
cancer
bifunctional compound
alkyl
disease
cdk8
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CA3020543A
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English (en)
French (fr)
Inventor
Nathanael Gray
Tinghu Zhang
Calla M. OLSON
Yanke LIANG
Nicholas KWIATKOWSKI
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CA3020543A1 publication Critical patent/CA3020543A1/en
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CA3020543A 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use Pending CA3020543A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662326584P 2016-04-22 2016-04-22
US62/326,584 2016-04-22
PCT/US2017/028948 WO2017185034A1 (en) 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use

Publications (1)

Publication Number Publication Date
CA3020543A1 true CA3020543A1 (en) 2017-10-26

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CA3020543A Pending CA3020543A1 (en) 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use

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US (3) US10865205B2 (enExample)
EP (2) EP3985006A1 (enExample)
JP (1) JP6921114B2 (enExample)
CN (1) CN109311869B (enExample)
AU (1) AU2017254711B2 (enExample)
CA (1) CA3020543A1 (enExample)
WO (1) WO2017185034A1 (enExample)

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