CA3020172A1 - Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders - Google Patents

Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders Download PDF

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Publication number
CA3020172A1
CA3020172A1 CA3020172A CA3020172A CA3020172A1 CA 3020172 A1 CA3020172 A1 CA 3020172A1 CA 3020172 A CA3020172 A CA 3020172A CA 3020172 A CA3020172 A CA 3020172A CA 3020172 A1 CA3020172 A1 CA 3020172A1
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alkyl
optionally substituted
aryl
compound
hydrogen
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English (en)
French (fr)
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Nathanael S. Gray
Tinghu Zhang
Fleur M. FERGUSON
Jean Zhao
Jing Ni
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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CA3020172A 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders Pending CA3020172A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319459P 2016-04-07 2016-04-07
US62/319,459 2016-04-07
PCT/US2017/026522 WO2017177092A1 (en) 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders

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CA3020172A1 true CA3020172A1 (en) 2017-10-12

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CA3020172A Pending CA3020172A1 (en) 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders

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US (1) US11155556B2 (enExample)
EP (1) EP3440084B1 (enExample)
JP (1) JP6968819B2 (enExample)
KR (1) KR20180132812A (enExample)
CN (1) CN109311901A (enExample)
AU (1) AU2017248186B2 (enExample)
CA (1) CA3020172A1 (enExample)
WO (1) WO2017177092A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
JP2021514011A (ja) * 2018-02-20 2021-06-03 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒ阻害剤の組合せ医薬製剤およびその使用法
EP3755690A4 (en) * 2018-02-20 2021-10-27 Dana-Farber Cancer Institute, Inc. EGFR INHIBITORS AND THEIR PROCESSES FOR USE
JP7335275B2 (ja) * 2018-02-20 2023-08-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒの阻害剤およびその使用法
CN110787168B (zh) * 2019-11-06 2022-06-24 中国医科大学 一种小分子化合物C29H28Cl2N6O在大肠杆菌性脑膜炎中的应用
CA3169649A1 (en) * 2020-01-30 2021-08-05 The Regents Of The University Of California Strad-binding agents and uses thereof
CN114539263B (zh) * 2020-11-11 2023-04-25 暨南大学 一类含氮并杂环化合物及其药用组合物和应用

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US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
TW200808325A (en) * 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds
WO2008040951A1 (en) * 2006-10-03 2008-04-10 Astrazeneca Ab Compounds
EP1953163A1 (en) * 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Pteridinone derivatives as PI3-kinases inhibitors
PT2139892E (pt) * 2007-03-22 2011-11-21 Takeda Pharmaceutical Pirimidodiazepinas substituídas úteis como inibidores da plk1
EP2610256B1 (en) * 2007-09-28 2016-04-27 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
EP2379559B1 (en) * 2009-01-06 2017-10-25 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
WO2012135009A1 (en) * 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
JP6553589B2 (ja) * 2013-03-15 2019-07-31 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド ピリミド−ジアゼピノン化合物および障害の治療方法
JP2017504651A (ja) * 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
WO2016201370A1 (en) * 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CA3012516A1 (en) * 2016-03-04 2017-09-08 Anhui New Star Pharmaceutical Development Co., Ltd Pyrimidine seven-membered-ring compounds, preparation method therefor, pharmaceutical composition therefor, and uses thereof
CA3040173A1 (en) * 2016-10-18 2018-04-26 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders

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Publication number Publication date
JP2019510801A (ja) 2019-04-18
WO2017177092A1 (en) 2017-10-12
KR20180132812A (ko) 2018-12-12
EP3440084A1 (en) 2019-02-13
EP3440084A4 (en) 2019-11-20
US11155556B2 (en) 2021-10-26
US20190106424A1 (en) 2019-04-11
AU2017248186A1 (en) 2018-10-04
AU2017248186B2 (en) 2021-10-21
JP6968819B2 (ja) 2021-11-17
CN109311901A (zh) 2019-02-05
EP3440084B1 (en) 2022-12-21

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