AU2017248186B2 - Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders - Google Patents

Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders Download PDF

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AU2017248186B2
AU2017248186B2 AU2017248186A AU2017248186A AU2017248186B2 AU 2017248186 B2 AU2017248186 B2 AU 2017248186B2 AU 2017248186 A AU2017248186 A AU 2017248186A AU 2017248186 A AU2017248186 A AU 2017248186A AU 2017248186 B2 AU2017248186 B2 AU 2017248186B2
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alkyl
compound
optionally substituted
kinase
pi3k
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AU2017248186A1 (en
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Fleur M. FERGUSON
Nathanael S. Gray
Jing Ni
Tinghu Zhang
Jean Zhao
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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AU2017248186A 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders Active AU2017248186B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319459P 2016-04-07 2016-04-07
US62/319,459 2016-04-07
PCT/US2017/026522 WO2017177092A1 (en) 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders

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AU2017248186A1 AU2017248186A1 (en) 2018-10-04
AU2017248186B2 true AU2017248186B2 (en) 2021-10-21

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US (1) US11155556B2 (enExample)
EP (1) EP3440084B1 (enExample)
JP (1) JP6968819B2 (enExample)
KR (1) KR20180132812A (enExample)
CN (1) CN109311901A (enExample)
AU (1) AU2017248186B2 (enExample)
CA (1) CA3020172A1 (enExample)
WO (1) WO2017177092A1 (enExample)

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JP2021514011A (ja) * 2018-02-20 2021-06-03 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒ阻害剤の組合せ医薬製剤およびその使用法
EP3755690A4 (en) * 2018-02-20 2021-10-27 Dana-Farber Cancer Institute, Inc. EGFR INHIBITORS AND THEIR PROCESSES FOR USE
JP7335275B2 (ja) * 2018-02-20 2023-08-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒの阻害剤およびその使用法
CN110787168B (zh) * 2019-11-06 2022-06-24 中国医科大学 一种小分子化合物C29H28Cl2N6O在大肠杆菌性脑膜炎中的应用
CA3169649A1 (en) * 2020-01-30 2021-08-05 The Regents Of The University Of California Strad-binding agents and uses thereof
CN114539263B (zh) * 2020-11-11 2023-04-25 暨南大学 一类含氮并杂环化合物及其药用组合物和应用

Citations (1)

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WO2014145909A2 (en) * 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders

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TW200808325A (en) * 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds
WO2008040951A1 (en) * 2006-10-03 2008-04-10 Astrazeneca Ab Compounds
EP1953163A1 (en) * 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Pteridinone derivatives as PI3-kinases inhibitors
PT2139892E (pt) * 2007-03-22 2011-11-21 Takeda Pharmaceutical Pirimidodiazepinas substituídas úteis como inibidores da plk1
EP2610256B1 (en) * 2007-09-28 2016-04-27 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
EP2379559B1 (en) * 2009-01-06 2017-10-25 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
WO2012135009A1 (en) * 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
JP2017504651A (ja) * 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
WO2016201370A1 (en) * 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CA3012516A1 (en) * 2016-03-04 2017-09-08 Anhui New Star Pharmaceutical Development Co., Ltd Pyrimidine seven-membered-ring compounds, preparation method therefor, pharmaceutical composition therefor, and uses thereof
CA3040173A1 (en) * 2016-10-18 2018-04-26 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders

Patent Citations (1)

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WO2014145909A2 (en) * 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders

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JP2019510801A (ja) 2019-04-18
CA3020172A1 (en) 2017-10-12
WO2017177092A1 (en) 2017-10-12
KR20180132812A (ko) 2018-12-12
EP3440084A1 (en) 2019-02-13
EP3440084A4 (en) 2019-11-20
US11155556B2 (en) 2021-10-26
US20190106424A1 (en) 2019-04-11
AU2017248186A1 (en) 2018-10-04
JP6968819B2 (ja) 2021-11-17
CN109311901A (zh) 2019-02-05
EP3440084B1 (en) 2022-12-21

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