CA3017567A1 - Compounds and methods for modulating bruton's tyrosine kinase - Google Patents
Compounds and methods for modulating bruton's tyrosine kinase Download PDFInfo
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- CA3017567A1 CA3017567A1 CA3017567A CA3017567A CA3017567A1 CA 3017567 A1 CA3017567 A1 CA 3017567A1 CA 3017567 A CA3017567 A CA 3017567A CA 3017567 A CA3017567 A CA 3017567A CA 3017567 A1 CA3017567 A1 CA 3017567A1
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Landscapes
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| PCT/US2017/021966 WO2017156495A1 (en) | 2016-03-11 | 2017-03-10 | Compounds and methods for modulating bruton's tyrosine kinase |
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| CN110494433B (zh) | 2017-03-22 | 2023-03-17 | 廖细斌 | 布鲁顿酪氨酸激酶抑制剂 |
| KR102384924B1 (ko) * | 2017-07-12 | 2022-04-08 | 주식회사 대웅제약 | 신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물 |
| CN108191871B (zh) * | 2018-01-02 | 2020-02-18 | 成都倍特药业有限公司 | 新型布鲁顿酪氨酸激酶抑制剂及其制备方法和应用 |
| CN111662232B (zh) * | 2019-03-06 | 2022-08-02 | 中国科学院上海药物研究所 | 具有2h-吲唑结构的小分子化合物及其合成和应用 |
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| CN114437078A (zh) * | 2020-11-03 | 2022-05-06 | 海思科医药集团股份有限公司 | 一种降解btk的氘代物及其在医药上的应用 |
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| MX2014000518A (es) | 2011-07-13 | 2014-05-30 | Pharmacyclics Inc | Inhibidores de la tirosina quinasa de bruton. |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| US9458162B2 (en) | 2012-01-31 | 2016-10-04 | Nanjing Allgen Pharma Co. Ltd. | Cyclic molecules as bruton's tyrosine kinase inhibitors |
| WO2014022569A1 (en) | 2012-08-03 | 2014-02-06 | Principia Biopharma Inc. | Treatment of dry eye |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| EP3060218A4 (en) | 2013-10-25 | 2017-07-19 | Pharmacyclics LLC | Methods of treating and preventing graft versus host disease |
| WO2015124570A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of influenza a virus infection |
| CN108349940B (zh) * | 2015-10-14 | 2021-08-13 | 淄博百极常生制药有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| IL260691B (en) * | 2016-01-21 | 2022-07-01 | Zibo Biopolar Changsheng Pharmaceutical Co Ltd | Bruton's tyrosine kinase inhibitors |
| MX388026B (es) * | 2016-03-11 | 2025-03-19 | Angel Pharmaceutical Co Ltd | Compuestos y métodos para modular la tirosina cinasa de bruton. |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113329748A (zh) * | 2018-10-10 | 2021-08-31 | 福马治疗股份有限公司 | 抑制脂肪酸合酶(fasn) |
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| US10870652B2 (en) | 2020-12-22 |
| JP2019507793A (ja) | 2019-03-22 |
| JP6972002B2 (ja) | 2021-11-24 |
| WO2017156495A1 (en) | 2017-09-14 |
| KR102416971B1 (ko) | 2022-07-04 |
| EP3426637A1 (en) | 2019-01-16 |
| IL261583A (en) | 2018-10-31 |
| ZA201805951B (en) | 2020-12-23 |
| PL3426637T3 (pl) | 2022-05-30 |
| NZ745927A (en) | 2024-05-31 |
| MX388026B (es) | 2025-03-19 |
| EP3426637A4 (en) | 2019-09-18 |
| MX2018010971A (es) | 2019-03-28 |
| CN109071455B (zh) | 2022-08-02 |
| EP3426637B1 (en) | 2022-02-09 |
| US20190106423A1 (en) | 2019-04-11 |
| ES2912465T3 (es) | 2022-05-26 |
| KR20180133415A (ko) | 2018-12-14 |
| CN109071455A (zh) | 2018-12-21 |
| US11306099B1 (en) | 2022-04-19 |
| AU2017230098A1 (en) | 2018-09-20 |
| AU2017230098B2 (en) | 2021-03-25 |
| WO2017156495A8 (en) | 2018-09-27 |
| CN115746000A (zh) | 2023-03-07 |
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