CA3011014A1 - Compositions and methods for generating an immune response to a tumor associated antigen - Google Patents

Compositions and methods for generating an immune response to a tumor associated antigen Download PDF

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Publication number
CA3011014A1
CA3011014A1 CA3011014A CA3011014A CA3011014A1 CA 3011014 A1 CA3011014 A1 CA 3011014A1 CA 3011014 A CA3011014 A CA 3011014A CA 3011014 A CA3011014 A CA 3011014A CA 3011014 A1 CA3011014 A1 CA 3011014A1
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Prior art keywords
sequence
taa
mva
vector
immune response
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CA3011014A
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English (en)
French (fr)
Inventor
Harriet Robinson
Arban Domi
Michael Hellerstein
Farshad Guirakhoo
Nathanael Paul McCurley
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Geovax Inc
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Publication of CA3011014A1 publication Critical patent/CA3011014A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001181—Alpha-feto protein
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    • A61K39/001182—Carcinoembryonic antigen [CEA]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
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    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
    • C12N2760/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3011014A 2016-01-08 2017-01-09 Compositions and methods for generating an immune response to a tumor associated antigen Pending CA3011014A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662276479P 2016-01-08 2016-01-08
US62/276,479 2016-01-08
US201662301885P 2016-03-01 2016-03-01
US62/301,885 2016-03-01
PCT/US2017/012704 WO2017120577A1 (en) 2016-01-08 2017-01-09 Compositions and methods for generating an immune response to a tumor associated antigen

Publications (1)

Publication Number Publication Date
CA3011014A1 true CA3011014A1 (en) 2017-07-13

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CA3011014A Pending CA3011014A1 (en) 2016-01-08 2017-01-09 Compositions and methods for generating an immune response to a tumor associated antigen

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US (3) US11278607B2 (enExample)
EP (1) EP3402802B1 (enExample)
JP (3) JP7150611B2 (enExample)
CN (2) CN109071592B (enExample)
AU (2) AU2017206102C1 (enExample)
CA (1) CA3011014A1 (enExample)
ES (1) ES2944314T3 (enExample)
PL (1) PL3402802T3 (enExample)
WO (1) WO2017120577A1 (enExample)

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CN109071592B (zh) 2016-01-08 2022-07-19 吉奥瓦科斯公司 用于产生对肿瘤相关抗原的免疫应答的组合物和方法
US20190030157A1 (en) 2016-02-03 2019-01-31 Geovax Inc. Compositions and Methods for Generating an Immune Response to a Flavivirus
US20210220469A1 (en) * 2017-08-25 2021-07-22 Geovax, Inc. Immuno-Oncology Compositions and Methods for Use Thereof
US11311612B2 (en) 2017-09-19 2022-04-26 Geovax, Inc. Compositions and methods for generating an immune response to treat or prevent malaria
US20210369825A1 (en) * 2018-10-05 2021-12-02 Nantcell, Inc. Cd40 and cd40l combo in an adv vaccine vehicle
JP7670705B2 (ja) * 2019-11-20 2025-04-30 バヴァリアン・ノルディック・アクティーゼルスカブ ４－１ｂｂｌアジュバント添加した組み換え改変ワクシニアウイルスアンカラ（ｍｖａ）の医学的使用
CA3167052A1 (en) 2020-02-14 2021-08-19 Mary Jo Hauser Vaccines and uses thereof to induce an immune response to sars-cov2
JP7584763B2 (ja) * 2020-06-04 2024-11-18 東亞合成株式会社 抗ウイルス性ペプチドおよびその利用

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