AU2017206102C1 - Compositions and methods for generating an immune response to a tumor associated antigen - Google Patents
Compositions and methods for generating an immune response to a tumor associated antigen Download PDFInfo
- Publication number
- AU2017206102C1 AU2017206102C1 AU2017206102A AU2017206102A AU2017206102C1 AU 2017206102 C1 AU2017206102 C1 AU 2017206102C1 AU 2017206102 A AU2017206102 A AU 2017206102A AU 2017206102 A AU2017206102 A AU 2017206102A AU 2017206102 C1 AU2017206102 C1 AU 2017206102C1
- Authority
- AU
- Australia
- Prior art keywords
- acid sequence
- nucleic acid
- mva
- sequence
- taa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/00117—Mucins, e.g. MUC-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001181—Alpha-feto protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
- C12N2760/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021261945A AU2021261945B2 (en) | 2016-01-08 | 2021-11-05 | Compositions and methods for generating an immune response to a tumor associated antigen |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276479P | 2016-01-08 | 2016-01-08 | |
| US62/276,479 | 2016-01-08 | ||
| US201662301885P | 2016-03-01 | 2016-03-01 | |
| US62/301,885 | 2016-03-01 | ||
| PCT/US2017/012704 WO2017120577A1 (en) | 2016-01-08 | 2017-01-09 | Compositions and methods for generating an immune response to a tumor associated antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021261945A Division AU2021261945B2 (en) | 2016-01-08 | 2021-11-05 | Compositions and methods for generating an immune response to a tumor associated antigen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2017206102A1 AU2017206102A1 (en) | 2018-07-19 |
| AU2017206102B2 AU2017206102B2 (en) | 2021-08-26 |
| AU2017206102C1 true AU2017206102C1 (en) | 2022-02-10 |
Family
ID=59274065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017206102A Active AU2017206102C1 (en) | 2016-01-08 | 2017-01-09 | Compositions and methods for generating an immune response to a tumor associated antigen |
| AU2021261945A Active AU2021261945B2 (en) | 2016-01-08 | 2021-11-05 | Compositions and methods for generating an immune response to a tumor associated antigen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021261945A Active AU2021261945B2 (en) | 2016-01-08 | 2021-11-05 | Compositions and methods for generating an immune response to a tumor associated antigen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11278607B2 (enExample) |
| EP (1) | EP3402802B1 (enExample) |
| JP (3) | JP7150611B2 (enExample) |
| CN (2) | CN109071592B (enExample) |
| AU (2) | AU2017206102C1 (enExample) |
| CA (1) | CA3011014A1 (enExample) |
| ES (1) | ES2944314T3 (enExample) |
| PL (1) | PL3402802T3 (enExample) |
| WO (1) | WO2017120577A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3011014A1 (en) | 2016-01-08 | 2017-07-13 | Geovax, Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| WO2017136419A1 (en) | 2016-02-03 | 2017-08-10 | Geovax Inc. | Compositions and methods for generating an immune response to a flavivirus |
| US20210220469A1 (en) * | 2017-08-25 | 2021-07-22 | Geovax, Inc. | Immuno-Oncology Compositions and Methods for Use Thereof |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| US20210369825A1 (en) * | 2018-10-05 | 2021-12-02 | Nantcell, Inc. | Cd40 and cd40l combo in an adv vaccine vehicle |
| US20230059344A1 (en) * | 2019-11-20 | 2023-02-23 | Bavarian Nordic A/S | Medical Uses of 4-1BBL Adjuvanted Recombinant Modified Vaccinia Virus Ankara (MVA) |
| IL295482A (en) | 2020-02-14 | 2022-10-01 | Geovax Inc | Vaccines and their uses to induce an immune response to sars-cov2 |
| JP7584763B2 (ja) * | 2020-06-04 | 2024-11-18 | 東亞合成株式会社 | 抗ウイルス性ペプチドおよびその利用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070160627A1 (en) * | 2003-09-29 | 2007-07-12 | Caroline Staib | Modified vaccinia virus ankara (MVA) mutant and use thereof |
| WO2015066715A1 (en) * | 2013-11-04 | 2015-05-07 | Viracell Advanced Products, Llc | Virus-like particles and methods related thereto |
| WO2015175340A1 (en) * | 2014-05-13 | 2015-11-19 | Bavarian Nordic, Inc. | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787901A (fr) | 1971-09-11 | 1972-12-18 | Freistaat Bayern Represente Pa | Vaccin antivariolique |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| JPH0795954B2 (ja) | 1982-11-30 | 1995-10-18 | アメリカ合衆国 | 外来性遺伝子発現のためのポックスウイルス組換え体の製造方法 |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5445953A (en) | 1991-08-26 | 1995-08-29 | Immuno Aktiengesellschaft | Direct molecular cloning of a modified poxvirus genome |
| EP1380651A2 (en) | 1991-08-26 | 2004-01-14 | Baxter Healthcare S.A. | Recombinant fowlpox virus with intact FPV-tk-gene |
| DE69229390T2 (de) | 1991-08-26 | 1999-11-11 | Immuno Ag, Wien | Direkt molekuläre Klonierung eines modifizierten Genoms eines Chordopocken-Virus |
| AU5679394A (en) | 1992-11-25 | 1994-06-22 | International Biotechnology Laboratories, Inc. | Hepatitis b virus vaccines |
| UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| EP0942747A1 (en) | 1996-08-26 | 1999-09-22 | Chiron Corporation | Postinfection human immunodeficiency virus (hiv) vaccination therapy |
| US6962708B1 (en) | 1997-02-28 | 2005-11-08 | Acambis, Inc. | Chimeric flavivirus vaccines |
| AUPP380598A0 (en) | 1998-05-29 | 1998-06-25 | Commonwealth Scientific And Industrial Research Organisation | Genetically manipulated entomopoxvirus |
| US6294176B1 (en) | 1998-07-10 | 2001-09-25 | Schering-Plough Veterinary Corp. | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species |
| WO2001092470A2 (en) | 2000-03-02 | 2001-12-06 | Emory University | Dna expression vectors and methods of use |
| US8623379B2 (en) | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| PT1372710E (pt) | 2001-03-08 | 2009-12-21 | Us Gov Health & Human Serv | Vam modificado que expressa os genes gag e pol do envelope de vih |
| EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
| US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| US7211378B2 (en) * | 2002-01-31 | 2007-05-01 | Wisconsin Alumni Research Foundation | Filovirus vectors and noninfectious filovirus-based particles |
| US7025970B2 (en) | 2002-03-15 | 2006-04-11 | Baxter International Inc. | Modified poxviruses, including modified smallpox virus vaccine based on recombinant drug-sensitive vaccinia virus, and new selection methods |
| PL218318B1 (pl) | 2002-05-16 | 2014-11-28 | Bavarian Nordic As | Rekombinowany wirus krowianki Ankara (MVA), zawierająca go komórka, szczepionka lub kompozycja farmaceutyczna, sposób lub zestaw do jego otrzymywania, sekwencja DNA zawierająca genom tego wirusa oraz sposób wykrywania tego wirusa lub komórek nim zainfekowanych |
| US20060088909A1 (en) | 2002-05-17 | 2006-04-27 | Compans Richard W | Virus-like particles, methods of preparation, and immunogenic compositions |
| US9045727B2 (en) | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
| WO2003106648A2 (en) * | 2002-06-14 | 2003-12-24 | Diadexus, Inc. | Compositions and methods relating to breast specific genes and proteins |
| DE10249390A1 (de) | 2002-10-23 | 2004-05-13 | Ruprecht-Karls-Universität Heidelberg | Rekombinante MVA-Stämme als potentielle Impfstoffe gegen P.falciparum-Malaria |
| US20040109876A1 (en) | 2002-11-25 | 2004-06-10 | Kureha Chemical Industry Co., Ltd. | Vaccine composition, HIV-infection suppression factor and method for the vaccination against HIV |
| AU2003293675B2 (en) | 2002-11-25 | 2009-04-23 | Bavarian Nordic A/S | Recombinant poxvirus comprising at least two cowpox ATI promoters |
| EP1601333B1 (en) | 2003-02-20 | 2013-01-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Novel insertion sites in pox vectors |
| US20060099225A1 (en) | 2004-04-13 | 2006-05-11 | Sina Bavari | Generation of virus-like particles and use as panfilovirus vaccine |
| EP2497831B1 (en) | 2004-05-25 | 2014-07-16 | Oregon Health and Science University | TB vaccination using HCMV-based vaccine vectors |
| ES2539010T3 (es) * | 2004-08-27 | 2015-06-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Virus MVA recombinantes que expresan genes env, gag y pol modificados de VIH clado A/G, clado B, y clado C |
| EP1683870A1 (en) * | 2005-01-24 | 2006-07-26 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vaccines based on the use of MVA |
| JP2008543276A (ja) * | 2005-03-30 | 2008-12-04 | ミネルバ バイオテクノロジーズ コーポレーション | Muc1発現細胞の増殖 |
| WO2006130525A2 (en) * | 2005-05-31 | 2006-12-07 | Sidney Kimmel Cancer Center | Methods for immunotherapy of cancer |
| ES2281252B1 (es) | 2005-07-27 | 2009-02-16 | Consejo Superior De Investigaciones Cientificas | Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida. |
| ES2611975T3 (es) | 2006-06-20 | 2017-05-11 | Transgene S.A. | Procedimiento para producir poxvirus y composiciones de poxvirus |
| CA2657648A1 (en) | 2006-07-13 | 2008-01-17 | Emory University | Virosomes, methods of preparation, and immunogenic compositions |
| WO2008142479A2 (en) | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| US20090092628A1 (en) | 2007-03-02 | 2009-04-09 | James Mullins | Conserved-element vaccines and methods for designing conserved-element vaccines |
| CA2688548A1 (en) | 2007-05-02 | 2009-01-15 | Emory University | Enhancement of glycoprotein incorporation into virus-like particles |
| JP6035503B2 (ja) | 2007-05-31 | 2016-11-30 | アカデミシュ ジーケンハウス ライデン ハー.オー.デー.エン. ルムク | ワクチンで使用するための、子宮頸部悪性腫瘍に浸潤するt細胞によって標的とされるhpvエピトープ |
| US11202775B2 (en) | 2007-09-25 | 2021-12-21 | Minerva Biotechnologies Corporation | Methods for treatment of cancer |
| WO2009079564A2 (en) | 2007-12-17 | 2009-06-25 | Emory University | Immunogenic compositions and methods of use thereof |
| AU2009319979B2 (en) | 2008-11-03 | 2016-10-20 | Takeda Vaccines, Inc. | Improved methods for isolating enveloped virus-based VLPs free of infectious agents |
| CA2774475A1 (en) | 2009-09-16 | 2011-03-24 | The Administrators Of The Tulane Educational Fund | Lassa virus-like particles and methods of production thereof |
| AP2012006258A0 (en) | 2009-10-13 | 2012-06-30 | Geovax Inc | Eliciting immune responses using recombinant MVA viruses expressing HIV ENV, GAG and POL antigens. |
| AU2010306559B2 (en) * | 2009-10-16 | 2015-07-16 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services . | Recombinant modified vaccinia Ankara (MVA) vaccinia virus containing restructured insertion sites |
| CN102844663B (zh) * | 2010-01-27 | 2016-01-06 | 俄勒冈健康科学大学 | 基于巨细胞病毒的免疫原性制剂 |
| WO2011103417A2 (en) | 2010-02-18 | 2011-08-25 | Emory University Of Technology Transfer | Vectors expressing hiv antigens and gm-csf and related methods for generating an immune response |
| US20120052082A1 (en) | 2010-04-09 | 2012-03-01 | Zetra Biologicals, LLC | Cross-protective influenza vaccine |
| WO2011130627A2 (en) | 2010-04-16 | 2011-10-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Chimpanzee adenoviral vector-based filovirus vaccines |
| CN103209701B (zh) | 2010-06-11 | 2016-08-03 | 乔治亚大学研究基金公司 | 免疫原性疫苗 |
| AU2012212463B2 (en) * | 2011-01-31 | 2016-07-07 | Nanotherapeutics, Inc. | Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses |
| US9683020B2 (en) | 2011-08-01 | 2017-06-20 | Emory University | VLPS containing ligands and methods related thereto |
| WO2013059498A1 (en) | 2011-10-18 | 2013-04-25 | Geovax, Inc. | Mva vectors expressing polypeptides and having high level production in certain cell lines |
| US9463238B2 (en) | 2011-12-09 | 2016-10-11 | Bavarian Nordic A/S | Recombinant poxvirus vector comprising tetanus toxin fragment C |
| US20150140068A1 (en) | 2012-07-06 | 2015-05-21 | Novartis Ag | Immunogenic compositions and uses thereof |
| EP2945649B1 (en) | 2013-01-22 | 2018-12-12 | Oxford University Innovation Limited | Composition and uses thereof |
| WO2015009946A1 (en) | 2013-07-17 | 2015-01-22 | Emory University | Method of increasing immune response to hiv antigens |
| AU2014340201B2 (en) | 2013-10-23 | 2019-02-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HLA-A24 agonist epitopes of MUC1-C oncoprotein and compositions and methods of use |
| CA2959105C (en) * | 2014-09-03 | 2023-10-17 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) filovirus vaccine |
| WO2016068919A1 (en) | 2014-10-29 | 2016-05-06 | Geovax, Inc. | Combination therapy for treating viral reservoirs |
| US11701418B2 (en) | 2015-01-12 | 2023-07-18 | Geovax, Inc. | Replication-deficient modified vaccinia Ankara (MVA) expressing Ebola virus glycoprotein (GP) and matrix protein (VP40) |
| US10072058B2 (en) | 2015-04-29 | 2018-09-11 | Emory University | Chimeric virus-like particles incorporating fusion GPI anchored GM-CSF and IL-4 conjugates |
| CA3011014A1 (en) | 2016-01-08 | 2017-07-13 | Geovax, Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| WO2017136419A1 (en) | 2016-02-03 | 2017-08-10 | Geovax Inc. | Compositions and methods for generating an immune response to a flavivirus |
| CA3014419A1 (en) | 2016-02-16 | 2017-08-24 | Geovax Inc. | Multivalent hiv vaccine boost compositions and methods of use |
| WO2017210181A1 (en) | 2016-05-30 | 2017-12-07 | Geovax Inc. | Compositions and methods for generating an immune response to hepatitis b virus |
| WO2018195447A1 (en) | 2017-04-20 | 2018-10-25 | Geovax Labs, Inc. | Recombinant mva-based hiv immunogens and uses thereof |
| WO2019018501A1 (en) | 2017-07-18 | 2019-01-24 | Geovax Inc. | COMPOSITIONS AND METHODS FOR GENERATING LASV IMMUNE RESPONSE |
| US20210220469A1 (en) | 2017-08-25 | 2021-07-22 | Geovax, Inc. | Immuno-Oncology Compositions and Methods for Use Thereof |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| WO2020247547A1 (en) | 2019-06-03 | 2020-12-10 | Geovax, Inc. | Cancer vaccine compositions and methods for use thereof |
-
2017
- 2017-01-09 CA CA3011014A patent/CA3011014A1/en active Pending
- 2017-01-09 AU AU2017206102A patent/AU2017206102C1/en active Active
- 2017-01-09 PL PL17736506.1T patent/PL3402802T3/pl unknown
- 2017-01-09 ES ES17736506T patent/ES2944314T3/es active Active
- 2017-01-09 CN CN201780016086.9A patent/CN109071592B/zh active Active
- 2017-01-09 WO PCT/US2017/012704 patent/WO2017120577A1/en not_active Ceased
- 2017-01-09 CN CN202210789628.9A patent/CN116064669A/zh active Pending
- 2017-01-09 JP JP2018554648A patent/JP7150611B2/ja active Active
- 2017-01-09 US US16/068,527 patent/US11278607B2/en active Active
- 2017-01-09 EP EP17736506.1A patent/EP3402802B1/en active Active
-
2020
- 2020-02-20 US US16/796,350 patent/US11413341B2/en active Active
-
2021
- 2021-11-05 AU AU2021261945A patent/AU2021261945B2/en active Active
-
2022
- 2022-07-29 US US17/876,682 patent/US12247214B2/en active Active
- 2022-09-27 JP JP2022153352A patent/JP2022185011A/ja not_active Ceased
-
2024
- 2024-02-13 JP JP2024019248A patent/JP2024056839A/ja not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070160627A1 (en) * | 2003-09-29 | 2007-07-12 | Caroline Staib | Modified vaccinia virus ankara (MVA) mutant and use thereof |
| WO2015066715A1 (en) * | 2013-11-04 | 2015-05-07 | Viracell Advanced Products, Llc | Virus-like particles and methods related thereto |
| WO2015175340A1 (en) * | 2014-05-13 | 2015-11-19 | Bavarian Nordic, Inc. | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3 |
Non-Patent Citations (1)
| Title |
|---|
| ADU-GYAMFI et al.,"The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress",J.Infect.Dis., (2014-01-07),vol.288,no.8, doi:10.1074/jbc.M112.443960,p 5779-5789 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3402802A1 (en) | 2018-11-21 |
| AU2017206102A1 (en) | 2018-07-19 |
| US20190290745A1 (en) | 2019-09-26 |
| PL3402802T3 (pl) | 2023-06-05 |
| CN109071592B (zh) | 2022-07-19 |
| US11413341B2 (en) | 2022-08-16 |
| AU2017206102B2 (en) | 2021-08-26 |
| US20200289633A1 (en) | 2020-09-17 |
| US11278607B2 (en) | 2022-03-22 |
| CN109071592A (zh) | 2018-12-21 |
| EP3402802B1 (en) | 2023-04-12 |
| JP7150611B2 (ja) | 2022-10-11 |
| CA3011014A1 (en) | 2017-07-13 |
| WO2017120577A1 (en) | 2017-07-13 |
| JP2024056839A (ja) | 2024-04-23 |
| JP2022185011A (ja) | 2022-12-13 |
| US20230040403A1 (en) | 2023-02-09 |
| US12247214B2 (en) | 2025-03-11 |
| JP2019500907A (ja) | 2019-01-17 |
| EP3402802A4 (en) | 2019-08-21 |
| ES2944314T3 (es) | 2023-06-20 |
| AU2021261945A1 (en) | 2021-12-02 |
| AU2021261945B2 (en) | 2024-12-12 |
| CN116064669A (zh) | 2023-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2021261945B2 (en) | Compositions and methods for generating an immune response to a tumor associated antigen | |
| US20220160853A1 (en) | Cancer vaccine compositions and methods for use thereof | |
| US20230256088A1 (en) | Immuno-oncology compositions and methods for use thereof | |
| US20220125919A1 (en) | Alphavirus neoantigen vectors and interferon inhibitors | |
| CA3099644A1 (en) | Shared antigens | |
| WO2019226939A1 (en) | Immune checkpoint inhibitor co-expression vectors | |
| KR20200076696A (ko) | 백신 t 세포 인핸서 | |
| CA3111305A1 (en) | Method for producing an antitumoral arenavirus as well as arenavirus mutants | |
| US20240254161A1 (en) | Neoantigens Expressed In Ovarian Cancer And Their Uses | |
| HK40093155A (zh) | 用於产生对肿瘤相关抗原的免疫应答的组合物和方法 | |
| EA051127B1 (ru) | Неоантигены, экспрессируемые в раке яичника, и их применение | |
| HK40102234A (zh) | 用於增强疫苗接种期间的t细胞启动的病毒构建体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 27 OCT 2021 |
|
| FGA | Letters patent sealed or granted (standard patent) |