CA3006077A1 - Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine - Google Patents
Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine Download PDFInfo
- Publication number
- CA3006077A1 CA3006077A1 CA3006077A CA3006077A CA3006077A1 CA 3006077 A1 CA3006077 A1 CA 3006077A1 CA 3006077 A CA3006077 A CA 3006077A CA 3006077 A CA3006077 A CA 3006077A CA 3006077 A1 CA3006077 A1 CA 3006077A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- slurry
- mixture
- optionally
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268758P | 2015-12-17 | 2015-12-17 | |
| US62/268,758 | 2015-12-17 | ||
| PCT/US2016/067161 WO2017106639A1 (en) | 2015-12-17 | 2016-12-16 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3006077A1 true CA3006077A1 (en) | 2017-06-22 |
Family
ID=59057623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3006077A Pending CA3006077A1 (en) | 2015-12-17 | 2016-12-16 | Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9834519B2 (OSRAM) |
| EP (2) | EP3390368A4 (OSRAM) |
| JP (2) | JP6940504B2 (OSRAM) |
| KR (1) | KR20180085814A (OSRAM) |
| CN (2) | CN114874149A (OSRAM) |
| AU (2) | AU2016369520B2 (OSRAM) |
| BR (1) | BR112018012325A2 (OSRAM) |
| CA (1) | CA3006077A1 (OSRAM) |
| EA (1) | EA201891431A1 (OSRAM) |
| HK (1) | HK1255014A1 (OSRAM) |
| IL (1) | IL259557A (OSRAM) |
| MX (2) | MX2020012771A (OSRAM) |
| NZ (1) | NZ742785A (OSRAM) |
| SG (1) | SG11201804601TA (OSRAM) |
| TW (1) | TWI748972B (OSRAM) |
| WO (1) | WO2017106639A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3390368A4 (en) * | 2015-12-17 | 2019-07-03 | ArQule, Inc. | PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE |
| JP2018537499A (ja) | 2015-12-17 | 2018-12-20 | アークル インコーポレイテッド | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 |
| CN110669015A (zh) * | 2018-07-03 | 2020-01-10 | 上海喀露蓝科技有限公司 | 一种fgfr抑制剂的制备方法 |
| US10878412B2 (en) * | 2019-05-13 | 2020-12-29 | Truist Bank | In-line verification of transactions |
| WO2022053708A1 (en) | 2020-09-14 | 2022-03-17 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| CN101115749B (zh) * | 2004-12-17 | 2011-06-22 | 安姆根有限公司 | 氨基嘧啶化合物和使用方法 |
| ES2656496T3 (es) | 2006-12-29 | 2018-02-27 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos útiles como inhibidores de AXL |
| GB2449293A (en) * | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| EP2379506B1 (en) | 2008-12-30 | 2015-09-02 | ArQule, Inc. | Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds |
| CN103476770B (zh) | 2010-11-25 | 2017-02-15 | 拉蒂欧制药有限责任公司 | 阿法替尼盐和多晶型物 |
| WO2012177852A1 (en) * | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| WO2015150900A2 (en) * | 2014-03-31 | 2015-10-08 | Debiopharm International Sa | Fgfr fusions |
| EP3390368A4 (en) | 2015-12-17 | 2019-07-03 | ArQule, Inc. | PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE |
| JP2018537499A (ja) | 2015-12-17 | 2018-12-20 | アークル インコーポレイテッド | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 |
-
2016
- 2016-12-16 EP EP16876767.1A patent/EP3390368A4/en not_active Withdrawn
- 2016-12-16 KR KR1020187020433A patent/KR20180085814A/ko not_active Ceased
- 2016-12-16 AU AU2016369520A patent/AU2016369520B2/en not_active Ceased
- 2016-12-16 EA EA201891431A patent/EA201891431A1/ru unknown
- 2016-12-16 MX MX2020012771A patent/MX2020012771A/es unknown
- 2016-12-16 MX MX2018007415A patent/MX385672B/es unknown
- 2016-12-16 BR BR112018012325A patent/BR112018012325A2/pt not_active Application Discontinuation
- 2016-12-16 WO PCT/US2016/067161 patent/WO2017106639A1/en not_active Ceased
- 2016-12-16 CA CA3006077A patent/CA3006077A1/en active Pending
- 2016-12-16 NZ NZ742785A patent/NZ742785A/en not_active IP Right Cessation
- 2016-12-16 SG SG11201804601TA patent/SG11201804601TA/en unknown
- 2016-12-16 EP EP21216064.2A patent/EP4015508A1/en active Pending
- 2016-12-16 CN CN202210565751.2A patent/CN114874149A/zh active Pending
- 2016-12-16 US US15/381,418 patent/US9834519B2/en active Active
- 2016-12-16 TW TW105141874A patent/TWI748972B/zh not_active IP Right Cessation
- 2016-12-16 HK HK18114135.7A patent/HK1255014A1/zh unknown
- 2016-12-16 CN CN201680081965.5A patent/CN108602779A/zh active Pending
- 2016-12-16 JP JP2018531343A patent/JP6940504B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-01 US US15/800,648 patent/US10093632B2/en active Active
-
2018
- 2018-05-23 IL IL259557A patent/IL259557A/en unknown
-
2019
- 2019-04-22 US US16/390,205 patent/US10766868B2/en not_active Expired - Fee Related
- 2019-10-03 US US16/592,003 patent/US11279679B2/en active Active
-
2021
- 2021-04-28 AU AU2021202610A patent/AU2021202610B2/en not_active Ceased
- 2021-09-02 JP JP2021142864A patent/JP2021191782A/ja not_active Ceased
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |
|
| EEER | Examination request |
Effective date: 20211213 |