CA3005013C - Fviii peptides and their use in tolerising haemophiliacs - Google Patents

Fviii peptides and their use in tolerising haemophiliacs Download PDF

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Publication number
CA3005013C
CA3005013C CA3005013A CA3005013A CA3005013C CA 3005013 C CA3005013 C CA 3005013C CA 3005013 A CA3005013 A CA 3005013A CA 3005013 A CA3005013 A CA 3005013A CA 3005013 C CA3005013 C CA 3005013C
Authority
CA
Canada
Prior art keywords
peptide
peptides
fviii
factor viii
haemophilia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3005013A
Other languages
English (en)
French (fr)
Other versions
CA3005013A1 (en
Inventor
David Wraith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Worg Pharmaceuticals Zhejiang Co Ltd
Original Assignee
Apitope Technology Bristol Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apitope Technology Bristol Ltd filed Critical Apitope Technology Bristol Ltd
Publication of CA3005013A1 publication Critical patent/CA3005013A1/en
Application granted granted Critical
Publication of CA3005013C publication Critical patent/CA3005013C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3005013A 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs Active CA3005013C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0723712.6 2007-12-04
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides
CA2707559A CA2707559C (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2707559A Division CA2707559C (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Publications (2)

Publication Number Publication Date
CA3005013A1 CA3005013A1 (en) 2009-06-11
CA3005013C true CA3005013C (en) 2021-11-16

Family

ID=38982965

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3005013A Active CA3005013C (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs
CA2707559A Active CA2707559C (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2707559A Active CA2707559C (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Country Status (25)

Country Link
US (1) US8445448B2 (enExample)
EP (1) EP2227488B3 (enExample)
JP (2) JP5501245B2 (enExample)
KR (1) KR101519840B1 (enExample)
CN (2) CN103709234B (enExample)
AU (1) AU2008332968B2 (enExample)
BR (1) BRPI0820143A2 (enExample)
CA (2) CA3005013C (enExample)
CY (1) CY1115168T1 (enExample)
DK (1) DK2227488T6 (enExample)
EA (1) EA019370B1 (enExample)
EC (1) ECSP10010327A (enExample)
ES (1) ES2458315T7 (enExample)
GB (1) GB0723712D0 (enExample)
HR (1) HRP20140344T4 (enExample)
IL (1) IL205780A (enExample)
MX (1) MX2010006084A (enExample)
MY (1) MY150995A (enExample)
NZ (1) NZ585217A (enExample)
PL (1) PL2227488T6 (enExample)
PT (1) PT2227488E (enExample)
SI (1) SI2227488T1 (enExample)
UA (1) UA101003C2 (enExample)
WO (1) WO2009071886A1 (enExample)
ZA (1) ZA201002997B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1311542T1 (sl) 2000-08-21 2009-02-28 Apitope Technology Bristol Ltd Tolerogenski peptidi
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
SI2300497T1 (sl) * 2008-06-24 2013-02-28 Octapharma Ag Postopek za äťiĺˇäťenje koagulacijskega faktorja viii
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
US20120135917A1 (en) * 2009-06-16 2012-05-31 Eisaku Yoshihara Anti-Gram Negative Bacteria Agent
DK2632479T3 (en) * 2010-10-27 2017-08-07 Baxalta GmbH FVIII PEPTIDES FOR IMMUNT TOLERANCE INDUCTION AND IMMUNODIAGNOSTICS
PL3453402T3 (pl) 2012-01-12 2022-03-21 Bioverativ Therapeutics Inc. Zmniejszenie immunogenności przeciwko czynnikowi viii u osób poddawanych terapii czynnikiem viii
PL2917232T3 (pl) * 2012-11-12 2017-09-29 Apitope International Nv Pochodzące od czynnika VIII peptydy do zastosowania w leczeniu hemofilii A
GB201314052D0 (en) 2013-08-06 2013-09-18 Apitope Int Nv Peptides
WO2017096329A1 (en) 2015-12-03 2017-06-08 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods
BR112019011198A2 (pt) 2016-12-02 2019-12-17 Bioverativ Therapeutics Inc métodos de indução de tolerância imune a fatores de coagulação
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT94427A (pt) 1989-06-20 1991-03-20 Scripps Clinic Res Processo para a preparacao de polipeptidos que inibem a ligacao de factor viii humano a fosfolipidos
BR9806793A (pt) * 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
SI1311542T1 (sl) * 2000-08-21 2009-02-28 Apitope Technology Bristol Ltd Tolerogenski peptidi
US20040096456A1 (en) * 2000-12-01 2004-05-20 Conti-Fine Bianca M Method to treat hemophilia
AU2002233340B2 (en) * 2001-02-19 2008-05-22 Merck Patent Gmbh Artificial fusion proteins with reduced immunogenicity
AU2002312660A1 (en) * 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 修飾されたviii因子
SI1729795T1 (sl) * 2004-02-09 2016-04-29 Human Genome Sciences, Inc. Albuminski fuzijski proteini
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Also Published As

Publication number Publication date
CN103709234A (zh) 2014-04-09
EP2227488A1 (en) 2010-09-15
DK2227488T3 (da) 2014-04-22
PL2227488T6 (pl) 2015-04-30
HRP20140344T1 (en) 2014-05-09
ES2458315T7 (es) 2015-02-18
EA019370B1 (ru) 2014-03-31
HK1144292A1 (en) 2011-02-11
AU2008332968B2 (en) 2014-03-20
ES2458315T3 (es) 2014-04-30
PT2227488E (pt) 2014-04-21
MX2010006084A (es) 2010-06-23
DK2227488T6 (en) 2015-02-16
US20100323966A1 (en) 2010-12-23
WO2009071886A1 (en) 2009-06-11
CN101889024A (zh) 2010-11-17
AU2008332968A1 (en) 2009-06-11
EP2227488B1 (en) 2014-01-22
GB0723712D0 (en) 2008-01-16
US8445448B2 (en) 2013-05-21
JP6063402B2 (ja) 2017-01-18
JP5501245B2 (ja) 2014-05-21
CN103709234B (zh) 2017-01-18
HRP20140344T4 (hr) 2015-07-31
UA101003C2 (uk) 2013-02-25
EP2227488B3 (en) 2014-11-19
CY1115168T1 (el) 2016-12-14
ZA201002997B (en) 2011-07-27
BRPI0820143A2 (pt) 2015-05-12
KR20100087346A (ko) 2010-08-04
CA3005013A1 (en) 2009-06-11
KR101519840B1 (ko) 2015-05-18
CA2707559C (en) 2018-07-03
IL205780A0 (en) 2010-11-30
NZ585217A (en) 2012-11-30
MY150995A (en) 2014-03-31
PL2227488T3 (pl) 2014-07-31
IL205780A (en) 2015-06-30
CN101889024B (zh) 2014-04-23
JP2011505414A (ja) 2011-02-24
CA2707559A1 (en) 2009-06-11
JP2014088440A (ja) 2014-05-15
SI2227488T1 (sl) 2014-06-30
EA201070681A1 (ru) 2010-10-29
ECSP10010327A (es) 2010-09-30

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180515

EEER Examination request

Effective date: 20180515