CA3004641A1 - Cyclic peptides targeting .alpha.4.beta.7 integrin - Google Patents

Cyclic peptides targeting .alpha.4.beta.7 integrin Download PDF

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Publication number
CA3004641A1
CA3004641A1 CA3004641A CA3004641A CA3004641A1 CA 3004641 A1 CA3004641 A1 CA 3004641A1 CA 3004641 A CA3004641 A CA 3004641A CA 3004641 A CA3004641 A CA 3004641A CA 3004641 A1 CA3004641 A1 CA 3004641A1
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CA
Canada
Prior art keywords
tert
butyl
compound
pro
disease
Prior art date
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Pending
Application number
CA3004641A
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English (en)
French (fr)
Inventor
Manuel Perez VAZQUEZ
M. Monzur MORSHED
Jennifer L. HICKEY
Adam Paul KAFAL
James Gillard
Sai Kumar Chakka
Andrew L. Roughton
Marc-Andre Poupart
Gaoqiang Yang
Narendra Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Montreal
Zealand Pharma AS
Original Assignee
University of Montreal
Encycle Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Montreal, Encycle Therapeutics Inc filed Critical University of Montreal
Publication of CA3004641A1 publication Critical patent/CA3004641A1/en
Pending legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
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    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
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CA3004641A 2015-11-11 2016-11-14 Cyclic peptides targeting .alpha.4.beta.7 integrin Pending CA3004641A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254003P 2015-11-11 2015-11-11
US62/254,003 2015-11-11
PCT/CA2016/000274 WO2017079820A1 (en) 2015-11-11 2016-11-14 CYCLIC PEPTIDES TARGETING α4β7 INTEGRIN

Publications (1)

Publication Number Publication Date
CA3004641A1 true CA3004641A1 (en) 2017-05-18

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA3004641A Pending CA3004641A1 (en) 2015-11-11 2016-11-14 Cyclic peptides targeting .alpha.4.beta.7 integrin
CA3004714A Pending CA3004714A1 (en) 2015-11-11 2016-11-14 Fragment synthesis of cyclic peptides

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Application Number Title Priority Date Filing Date
CA3004714A Pending CA3004714A1 (en) 2015-11-11 2016-11-14 Fragment synthesis of cyclic peptides

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Country Link
US (4) US11072616B2 (enExample)
EP (2) EP3377471A4 (enExample)
JP (1) JP6961586B2 (enExample)
KR (1) KR102867019B1 (enExample)
CN (2) CN109071430A (enExample)
AU (1) AU2016353547B9 (enExample)
CA (2) CA3004641A1 (enExample)
WO (2) WO2017079821A1 (enExample)

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EP3377471A4 (en) 2015-11-11 2019-11-20 Encycle Therapeutics, Inc. FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES
EP3939989A1 (en) 2016-11-11 2022-01-19 Zealand Pharma A/S Cyclic peptides multimers targeting alpha 4beta 7 integrin
KR20200015540A (ko) * 2017-05-10 2020-02-12 인사이클 세라퓨틱스, 인코포레이티드 α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드
CN110551178B (zh) * 2018-06-01 2020-07-21 深圳翰宇药业股份有限公司 一种含脯氨酸的首尾环肽合成方法
JP7670618B2 (ja) * 2019-03-14 2025-04-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 環状ペプチド抗生物質
JP2021106565A (ja) * 2019-12-27 2021-07-29 国立大学法人 東京大学 ライブラリーの製造方法、環状ペプチド、ＦＸＩＩａ結合剤、及びＩＦＮＧＲ１結合剤
EP4101929A4 (en) * 2019-12-27 2024-05-22 The University of Tokyo BANK CONSTRUCTION METHOD, CYCLIC PEPTIDE, FXIIA BINDER AND IFNGR1 BINDER
TWI908822B (zh) 2020-06-29 2025-12-21 丹麥商西蘭製藥公司 化合物
KR20240116921A (ko) 2021-12-20 2024-07-30 질랜드 파마 에이/에스 화합물
WO2026018016A1 (en) * 2024-07-19 2026-01-22 C4X Discovery Limited Therapeutic compounds
WO2026018017A1 (en) * 2024-07-19 2026-01-22 C4X Discovery Limited Therapeutic compounds

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AU2016353547A1 (en) 2018-06-28
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EP3387004A4 (en) 2019-11-20
KR102867019B1 (ko) 2025-09-30
EP3387004B1 (en) 2021-10-06
CA3004714A1 (en) 2017-05-18
AU2016353547B9 (en) 2020-12-03
KR20180095809A (ko) 2018-08-28
US20190077805A1 (en) 2019-03-14
US20210300932A1 (en) 2021-09-30
CN109071602B (zh) 2022-09-13
US11072616B2 (en) 2021-07-27
US20200361944A1 (en) 2020-11-19
JP6961586B2 (ja) 2021-11-05
EP3377471A1 (en) 2018-09-26
US11046695B2 (en) 2021-06-29
CN109071430A (zh) 2018-12-21
WO2017079821A1 (en) 2017-05-18
US20200165300A1 (en) 2020-05-28
US10981921B2 (en) 2021-04-20
WO2017079820A1 (en) 2017-05-18
AU2016353547B2 (en) 2020-08-06
CN109071602A (zh) 2018-12-21
EP3387004A1 (en) 2018-10-17

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