CA3004641A1 - Cyclic peptides targeting .alpha.4.beta.7 integrin - Google Patents

Cyclic peptides targeting .alpha.4.beta.7 integrin Download PDF

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Publication number
CA3004641A1
CA3004641A1 CA3004641A CA3004641A CA3004641A1 CA 3004641 A1 CA3004641 A1 CA 3004641A1 CA 3004641 A CA3004641 A CA 3004641A CA 3004641 A CA3004641 A CA 3004641A CA 3004641 A1 CA3004641 A1 CA 3004641A1
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Canada
Prior art keywords
tert
butyl
compound
pro
disease
Prior art date
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Pending
Application number
CA3004641A
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English (en)
French (fr)
Inventor
Manuel Perez VAZQUEZ
M. Monzur MORSHED
Jennifer L. HICKEY
Adam Paul KAFAL
James Gillard
Sai Kumar Chakka
Andrew L. Roughton
Marc-Andre Poupart
Gaoqiang Yang
Narendra Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Montreal
Zealand Pharma AS
Original Assignee
Universite de Montreal
Encycle Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Montreal, Encycle Therapeutics Inc filed Critical Universite de Montreal
Publication of CA3004641A1 publication Critical patent/CA3004641A1/en
Pending legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
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CA3004641A 2015-11-11 2016-11-14 Cyclic peptides targeting .alpha.4.beta.7 integrin Pending CA3004641A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254003P 2015-11-11 2015-11-11
US62/254,003 2015-11-11
PCT/CA2016/000274 WO2017079820A1 (en) 2015-11-11 2016-11-14 CYCLIC PEPTIDES TARGETING α4β7 INTEGRIN

Publications (1)

Publication Number Publication Date
CA3004641A1 true CA3004641A1 (en) 2017-05-18

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA3004641A Pending CA3004641A1 (en) 2015-11-11 2016-11-14 Cyclic peptides targeting .alpha.4.beta.7 integrin
CA3004714A Pending CA3004714A1 (en) 2015-11-11 2016-11-14 Fragment synthesis of cyclic peptides

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3004714A Pending CA3004714A1 (en) 2015-11-11 2016-11-14 Fragment synthesis of cyclic peptides

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US (4) US11072616B2 (enExample)
EP (2) EP3377471A4 (enExample)
JP (1) JP6961586B2 (enExample)
KR (1) KR102867019B1 (enExample)
CN (2) CN109071602B (enExample)
AU (1) AU2016353547B9 (enExample)
CA (2) CA3004641A1 (enExample)
WO (2) WO2017079821A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CA3004641A1 (en) 2015-11-11 2017-05-18 Encycle Therapeutics, Inc. Cyclic peptides targeting .alpha.4.beta.7 integrin
JP7035044B2 (ja) 2016-11-11 2022-03-14 ジーランド ファーマ エー／エス α４β７インテグリンを標的とする環状ペプチド多量体
EP3621980A4 (en) * 2017-05-10 2021-06-30 Zealand Pharma A/S HOMODETIC CYCLIC PEPTIDES TARGETING INTEGRIN ALPHA4 BETA7
CN110551178B (zh) * 2018-06-01 2020-07-21 深圳翰宇药业股份有限公司 一种含脯氨酸的首尾环肽合成方法
WO2020185999A1 (en) * 2019-03-14 2020-09-17 Genentech, Inc. Cyclic peptide antibiotics
EP4101929A4 (en) * 2019-12-27 2024-05-22 The University of Tokyo BANK CONSTRUCTION METHOD, CYCLIC PEPTIDE, FXIIA BINDER AND IFNGR1 BINDER
JP2021106565A (ja) * 2019-12-27 2021-07-29 国立大学法人 東京大学 ライブラリーの製造方法、環状ペプチド、ＦＸＩＩａ結合剤、及びＩＦＮＧＲ１結合剤
US20230295235A1 (en) 2020-06-29 2023-09-21 Zealand Pharma A/S Compounds targeting alpha4-beta7 integrin
IL313590A (en) 2021-12-20 2024-08-01 Zealand Pharma As Compounds

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US10981921B2 (en) 2021-04-20
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