CA2991921C - Methotrexate for proliferative vitreoretinopathy - Google Patents
Methotrexate for proliferative vitreoretinopathy Download PDFInfo
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- CA2991921C CA2991921C CA2991921A CA2991921A CA2991921C CA 2991921 C CA2991921 C CA 2991921C CA 2991921 A CA2991921 A CA 2991921A CA 2991921 A CA2991921 A CA 2991921A CA 2991921 C CA2991921 C CA 2991921C
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- 230000000472 traumatic effect Effects 0.000 description 1
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3200870A CA3200870A1 (en) | 2014-07-30 | 2015-07-30 | Methotrexate for proliferative vitreoretinopathy |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462030778P | 2014-07-30 | 2014-07-30 | |
| US62/030,778 | 2014-07-30 | ||
| PCT/US2015/042951 WO2016019165A1 (en) | 2014-07-30 | 2015-07-30 | Methotrexate for proliferative vitreoretinopathy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA3200870A Division CA3200870A1 (en) | 2014-07-30 | 2015-07-30 | Methotrexate for proliferative vitreoretinopathy |
Publications (2)
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| CA2991921A1 CA2991921A1 (en) | 2016-02-04 |
| CA2991921C true CA2991921C (en) | 2023-08-08 |
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| CA3200870A Pending CA3200870A1 (en) | 2014-07-30 | 2015-07-30 | Methotrexate for proliferative vitreoretinopathy |
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| CA3200870A Pending CA3200870A1 (en) | 2014-07-30 | 2015-07-30 | Methotrexate for proliferative vitreoretinopathy |
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| ES2969374T3 (es) * | 2014-07-30 | 2024-05-17 | Massachusetts Eye & Ear Infirmary | Metotrexato para la vitreorretinopatía proliferativa |
| WO2018027044A1 (en) * | 2016-08-05 | 2018-02-08 | Schepens Eye Research Institute | Idelalisib for treating proliferative vitreoretinopathy and abnormal intraocular neovascularization |
| JP7416700B2 (ja) | 2017-11-14 | 2024-01-17 | ザ スキーペンズ アイ リサーチ インスティチュート インコーポレイテッド | 増殖性硝子体網膜症および上皮間葉転換と関連付けられる状態の治療のためのｒｕｎｘ１阻害の方法 |
| WO2021051003A1 (en) | 2019-09-13 | 2021-03-18 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations of methotrexate |
| CN115804665A (zh) * | 2022-12-13 | 2023-03-17 | 南昌大学附属眼科医院 | 一种tpvr动物模型的建立方法 |
| US11911385B1 (en) | 2022-12-14 | 2024-02-27 | Aldeyra Therapeutics, Inc. | Methotrexate treatment methods |
| WO2024129979A1 (en) * | 2022-12-14 | 2024-06-20 | Aldeyra Therapeutics, Inc. | Methotrexate treatment methods |
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| US20020032734A1 (en) | 2000-07-26 | 2002-03-14 | Rhoads Geoffrey B. | Collateral data combined with user characteristics to select web site |
| AUPQ496500A0 (en) | 2000-01-06 | 2000-02-03 | University Of Sydney, The | Kit |
| US20040253243A1 (en) | 2003-01-21 | 2004-12-16 | David Epstein | Aptamer therapeutics useful in ocular pharmacotherapy |
| US20050255144A1 (en) | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| JP5001645B2 (ja) * | 2004-04-02 | 2012-08-15 | 電気化学工業株式会社 | ヒアルロン酸−メトトレキサート結合体 |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| DE602004022523D1 (de) | 2004-07-02 | 2009-09-24 | Novagali Pharma Sa | Verwendung von Emulsionen zur intra- und periocularen Injection |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| WO2006039336A2 (en) * | 2004-10-01 | 2006-04-13 | Ramscor, Inc. | Conveniently implantable sustained release drug compositions |
| US8231892B2 (en) | 2007-05-24 | 2012-07-31 | Allergan, Inc. | Biodegradable drug delivery system |
| US20090081277A1 (en) * | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
| WO2010047803A2 (en) | 2008-10-22 | 2010-04-29 | Oncotx, L.L.C. | A method for the treatment of proliferative disorders of the eye |
| US9770414B2 (en) | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
| US20140105956A1 (en) * | 2012-10-11 | 2014-04-17 | Rupak BANERJEE | Biodegradable polymer based microimplant for ocular drug delivery |
| CA3240136A1 (en) * | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| ES2969374T3 (es) * | 2014-07-30 | 2024-05-17 | Massachusetts Eye & Ear Infirmary | Metotrexato para la vitreorretinopatía proliferativa |
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| EP3791883A1 (en) | 2021-03-17 |
| JP2023145527A (ja) | 2023-10-11 |
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| US20210283135A1 (en) | 2021-09-16 |
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| JP2017523974A (ja) | 2017-08-24 |
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| JP2021059554A (ja) | 2021-04-15 |
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| US10098884B2 (en) | 2018-10-16 |
| EP4311575A2 (en) | 2024-01-31 |
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| ES2969374T3 (es) | 2024-05-17 |
| EP3174540A1 (en) | 2017-06-07 |
| WO2016019165A1 (en) | 2016-02-04 |
| US10828306B2 (en) | 2020-11-10 |
| US20200085827A1 (en) | 2020-03-19 |
| US20170216294A1 (en) | 2017-08-03 |
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