CA2991087C - Radiation carrier and use thereof in an optical sensor - Google Patents

Radiation carrier and use thereof in an optical sensor Download PDF

Info

Publication number
CA2991087C
CA2991087C CA2991087A CA2991087A CA2991087C CA 2991087 C CA2991087 C CA 2991087C CA 2991087 A CA2991087 A CA 2991087A CA 2991087 A CA2991087 A CA 2991087A CA 2991087 C CA2991087 C CA 2991087C
Authority
CA
Canada
Prior art keywords
radiation
emission
detector
carrier
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2991087A
Other languages
English (en)
French (fr)
Other versions
CA2991087A1 (en
Inventor
Dries Vercruysse
Original Assignee
Imec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imec filed Critical Imec
Publication of CA2991087A1 publication Critical patent/CA2991087A1/en
Application granted granted Critical
Publication of CA2991087C publication Critical patent/CA2991087C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0011—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form
    • G02B6/0033—Means for improving the coupling-out of light from the light guide
    • G02B6/0035—Means for improving the coupling-out of light from the light guide provided on the surface of the light guide or in the bulk of it
    • G02B6/0036—2-D arrangement of prisms, protrusions, indentations or roughened surfaces
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B6/122—Basic optical elements, e.g. light-guiding paths
    • G02B6/124—Geodesic lenses or integrated gratings
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/30—Optical coupling means for use between fibre and thin-film device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2991087A 2015-06-30 2016-06-30 Radiation carrier and use thereof in an optical sensor Expired - Fee Related CA2991087C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15174678.1 2015-06-30
EP15174678 2015-06-30
PCT/EP2016/065394 WO2017001609A1 (en) 2015-06-30 2016-06-30 Radiation carrier and use thereof in an optical sensor

Publications (2)

Publication Number Publication Date
CA2991087A1 CA2991087A1 (en) 2017-01-05
CA2991087C true CA2991087C (en) 2019-12-03

Family

ID=53491451

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2991087A Expired - Fee Related CA2991087C (en) 2015-06-30 2016-06-30 Radiation carrier and use thereof in an optical sensor

Country Status (6)

Country Link
US (2) US20180188152A1 (enExample)
EP (1) EP3317641B1 (enExample)
JP (1) JP6505260B2 (enExample)
CN (1) CN107850537B (enExample)
CA (1) CA2991087C (enExample)
WO (1) WO2017001609A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6505260B2 (ja) 2015-06-30 2019-04-24 アイメック・ヴェーゼットウェーＩｍｅｃ Ｖｚｗ 放射線搬送体および光学センサ中での放射線搬送体の使用
US10921236B2 (en) * 2016-07-20 2021-02-16 Imec Vzw Integrated lens free imaging device
CN115980918B (zh) * 2017-12-29 2026-02-24 根特大学 温度不敏感滤波器
KR102511896B1 (ko) 2018-03-29 2023-03-20 일루미나, 인코포레이티드 대물 렌즈를 사용하는 형광 이미징을 위한 조명
WO2020019809A1 (en) * 2018-07-26 2020-01-30 Boe Technology Group Co., Ltd. Microfluidic apparatus, method of detecting substance in microfluidic apparatus, and spectrometer
CN109724952B (zh) * 2018-11-21 2022-02-11 华南师范大学 一种光纤探头及其制备方法、光纤传感器及其应用
WO2021259646A1 (en) * 2020-06-24 2021-12-30 Asml Netherlands B.V. Monolithic particle inspection device
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
EP4012380B1 (en) 2020-12-08 2025-04-02 Imec VZW A light excitation and collection device and a method for light excitation and collection
US12517049B2 (en) * 2021-10-06 2026-01-06 Academia Sinica Detection system and a portable detection device
DE102021212505A1 (de) 2021-11-08 2023-05-11 Robert Bosch Gesellschaft mit beschränkter Haftung Optische Vorrichtung zum Anregen einer Probe, Analysegerät und Verfahren zum Anregen einer Probe
CN115406817B (zh) * 2022-07-21 2024-12-10 西安交通大学 基于微流控的颗粒检测器
CN116931145A (zh) * 2023-07-26 2023-10-24 武汉量子技术研究院 一种水凝胶超构光栅及单向荧光辐射调控方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351611A (en) * 1980-09-22 1982-09-28 Coulter Electronics, Inc. Monitoring of a detection zone utilizing zero order radiation from a concave reflecting grating
EP0266120A3 (en) 1986-10-31 1990-07-11 AT&T Corp. Generating an array of light spots having uniform intensity
US4906094A (en) 1987-04-23 1990-03-06 Sumitomo Chemical Co. Ltd. Fine particle measuring method and system and a flow cell for use in the system
GB8807486D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
US5303316A (en) * 1989-12-22 1994-04-12 David Sarnoff Research Center, Inc. Optical beam scanner
US5999256A (en) 1992-02-12 1999-12-07 Cambridge Consultants Limited Particle measurement system
DE4215908A1 (de) * 1992-05-14 1993-11-18 Ubbo Prof Dr Ricklefs Optische Einrichtung zur Bestimmung der Größe von Partikeln
JP3748571B2 (ja) * 1996-11-18 2006-02-22 ノバルティス アクチエンゲゼルシャフト 測定装置及びその使用方法
DE59811600D1 (de) * 1997-09-10 2004-07-29 Artificial Sensing Instr Asi A Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
JP2003522578A (ja) * 2000-02-18 2003-07-29 アーゴス インク 不均質組織における空間的に平均された励起−発光マップの生成
US7630063B2 (en) 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
EP2275802A1 (de) * 2000-08-09 2011-01-19 Artificial Sensing Instruments ASI AG Wellenleitergitterstruktur und optische Messanordnung
US6507391B2 (en) 2000-08-25 2003-01-14 Amnis Corporation Measuring the velocity of small moving objects such as cells
US7057712B2 (en) 2002-06-24 2006-06-06 Tsi Incorporated Analysis systems detecting particle size and fluorescence
AU2003275942A1 (en) 2002-11-01 2004-05-25 Technical University Of Denmark A microfluidic system and a microdevice for velocity measurement, a method of performing measurements and use hereof
JP2006170853A (ja) * 2004-12-16 2006-06-29 Sekisui Chem Co Ltd 分析デバイス、読取装置及び情報管理システム
CZ299489B6 (cs) * 2005-01-12 2008-08-13 Ústav fotoniky a elektroniky AV CR, v. v. i. Zpusob spektroskopie povrchových plazmonu pro senzory s povrchovými plazmony a senzorový element k provádení tohoto zpusobu
JP2006267052A (ja) * 2005-03-25 2006-10-05 Toshiba Corp 免疫反応測定用検査装置
US8471230B2 (en) * 2006-09-01 2013-06-25 Pacific Biosciences Of California, Inc. Waveguide substrates and optical systems and methods of use thereof
US7551359B2 (en) 2006-09-14 2009-06-23 3M Innovative Properties Company Beam splitter apparatus and system
CA2684221A1 (en) 2007-04-12 2008-10-23 Regents Of The University Of Minnesota Systems and methods for analyzing a particulate
CA2699319A1 (en) 2007-09-17 2009-03-26 Luminex Corporation Systems, storage mediums, and methods for identifying particles in flow
JP5080186B2 (ja) * 2007-09-26 2012-11-21 富士フイルム株式会社 分子分析光検出方法およびそれに用いられる分子分析光検出装置、並びにサンプルプレート
EP2331941B1 (en) * 2008-09-25 2014-11-12 Koninklijke Philips N.V. Detection system and method
JP5721940B2 (ja) * 2009-11-04 2015-05-20 オリンパス株式会社 光スペクトル検出方法
US8980550B2 (en) * 2009-12-15 2015-03-17 California Institute Of Technology Methods for measuring samples using consumer electronic devices and systems
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
JP6505260B2 (ja) 2015-06-30 2019-04-24 アイメック・ヴェーゼットウェーＩｍｅｃ Ｖｚｗ 放射線搬送体および光学センサ中での放射線搬送体の使用
EP3339834B1 (en) 2016-12-22 2021-11-10 IMEC vzw Flow cytometer with multiple intensity peak design

Also Published As

Publication number Publication date
CN107850537B (zh) 2020-05-19
US12031899B2 (en) 2024-07-09
JP2018528390A (ja) 2018-09-27
EP3317641A1 (en) 2018-05-09
US20180188152A1 (en) 2018-07-05
US20210072141A1 (en) 2021-03-11
CA2991087A1 (en) 2017-01-05
JP6505260B2 (ja) 2019-04-24
CN107850537A (zh) 2018-03-27
WO2017001609A1 (en) 2017-01-05
EP3317641B1 (en) 2019-03-06

Similar Documents

Publication Publication Date Title
US12031899B2 (en) Radiation carrier and use thereof in an optical sensor
US8618508B2 (en) Detection system and method
KR100696237B1 (ko) 통합형 다중-도파관 센서
JP5705432B2 (ja) 光学アッセイシステム
CN108387505A (zh) 一种基于微流控芯片的多功能光镊系统及方法
CN116438438A (zh) 用于基于流动的单颗粒和/或单分子分析的方法和设备
CN109791103A (zh) 使用薄透镜进行粒子检测
WO2012033957A2 (en) Delayed emission detection devices and methods
US20150233907A1 (en) Microfluidic chip for multi-analyte detection
US10018563B2 (en) Sample plate and analyzing method
JP2013511713A (ja) 向上した蛍光検出及び方法
US8570518B2 (en) Methods and materials for detection of target species
CA2591200A1 (en) Systems, illumination subsystems, and methods for increasing fluorescence emitted by a fluorophore
JP4480130B2 (ja) 光学分析装置
EP2163885A1 (en) Microarray characterization system and method
JP2002277396A (ja) 発光検出装置
BRPI0913786B1 (pt) Sistema de detecção e método de detecção

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190108

MKLA Lapsed

Effective date: 20220301

MKLA Lapsed

Effective date: 20200831