CA2987293C - Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne - Google Patents
Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne Download PDFInfo
- Publication number
- CA2987293C CA2987293C CA2987293A CA2987293A CA2987293C CA 2987293 C CA2987293 C CA 2987293C CA 2987293 A CA2987293 A CA 2987293A CA 2987293 A CA2987293 A CA 2987293A CA 2987293 C CA2987293 C CA 2987293C
- Authority
- CA
- Canada
- Prior art keywords
- vitamin
- acne
- magnesium
- taurine
- topical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 title claims abstract description 448
- 206010000496 acne Diseases 0.000 title claims abstract description 271
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 265
- 239000011777 magnesium Substances 0.000 title claims abstract description 229
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 229
- 229960003080 taurine Drugs 0.000 title claims abstract description 225
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 213
- 230000000699 topical effect Effects 0.000 title claims abstract description 119
- 238000011282 treatment Methods 0.000 title claims description 105
- 230000002265 prevention Effects 0.000 title claims description 15
- 239000000203 mixture Substances 0.000 title abstract description 191
- 238000009472 formulation Methods 0.000 title description 15
- 239000006071 cream Substances 0.000 claims description 77
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 36
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 34
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 34
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 34
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- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 33
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 29
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- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 22
- 229910052725 zinc Inorganic materials 0.000 claims description 21
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- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 20
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 18
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 18
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- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 18
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
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- Nutrition Science (AREA)
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562180842P | 2015-06-17 | 2015-06-17 | |
| US62/180,842 | 2015-06-17 | ||
| PCT/US2016/037050 WO2016205089A1 (en) | 2015-06-17 | 2016-06-10 | Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2987293A1 CA2987293A1 (en) | 2016-12-22 |
| CA2987293C true CA2987293C (en) | 2020-11-03 |
Family
ID=57546606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2987293A Expired - Fee Related CA2987293C (en) | 2015-06-17 | 2016-06-10 | Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9795633B2 (enExample) |
| EP (1) | EP3310366A4 (enExample) |
| JP (2) | JP6657394B2 (enExample) |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9642877B1 (en) * | 2016-01-06 | 2017-05-09 | Kenneth O. Russell | Method of administration of chromium and magnesium sulfate for treatment of acne |
| CA2987293C (en) * | 2015-06-17 | 2020-11-03 | Margaret Jean Profet | Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne |
| CN107049890B (zh) * | 2017-06-27 | 2020-04-03 | 广东芭薇生物科技股份有限公司 | 一种具有舒缓抗粉刺功效的护肤品 |
| KR102310566B1 (ko) * | 2018-05-21 | 2021-10-08 | 랩앤피플주식회사 | 여드름 완화 및 예방용 패치 |
| WO2019225948A1 (ko) * | 2018-05-21 | 2019-11-28 | 랩앤피플주식회사 | 여드름 완화 및 예방용 패치 |
| KR102651395B1 (ko) * | 2018-07-05 | 2024-03-26 | 랩앤피플주식회사 | 여드름 완화 및 예방용 화장품 조성물 |
| EP3738588A1 (en) | 2019-05-13 | 2020-11-18 | Margaret Jean Profet | Topical and oral formulations comprising taurine and magnesium for use in the treatment of rosacea |
| CA3137407A1 (fr) | 2019-05-16 | 2020-11-19 | Synapharm Industrial Synthesis | Compound and composition for use in the treatment of premenstrual syndrome and/or premenstrual dysphoric disorder |
| ES2917623T3 (es) * | 2019-05-16 | 2022-07-11 | Synapharm Ind Synthesis | Compuesto y composición para uso en el tratamiento del síndrome premenstrual y/o del trastorno disfórico premenstrual |
| WO2024118480A1 (en) * | 2022-11-28 | 2024-06-06 | Epiphany Biosciences | Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses |
Family Cites Families (20)
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| FR2384751A1 (fr) | 1977-03-23 | 1978-10-20 | Francaise Coop Pharma | Nouveaux derives de la taurine a activite neuro-musculaire renforcee |
| US4545977A (en) | 1985-01-11 | 1985-10-08 | G. D. Searle & Co. | Compositions and methods for treating severe acne with isotretinoin |
| CN1126596A (zh) * | 1995-01-11 | 1996-07-17 | 徐富中 | 一种治疗粉刺的制剂 |
| US5776498A (en) | 1995-11-06 | 1998-07-07 | Nutrition 21 | Magnesium taurate as an adjuvant to rapid thrombolytic therapy |
| US5582839A (en) | 1995-04-18 | 1996-12-10 | Nutrition 21 | Magnesium taurate and other mineral taurates |
| US5962517A (en) | 1997-01-31 | 1999-10-05 | Murad; Howard | Pharmaceutical compositions and methods for treating acne |
| US6558656B2 (en) | 2000-04-20 | 2003-05-06 | Morris Mann | Oral and topical compositions and methods related thereto in the treatment of acne |
| US20040039042A1 (en) | 2002-08-23 | 2004-02-26 | Fleming Thomas E. | Method of transdermal drug delivery |
| US20040214891A1 (en) | 2003-04-22 | 2004-10-28 | Janusz Marcinkiewicz | Method for inhibiting pathogenic bacteria and fungi growth and microbicidal composition |
| US20050008684A1 (en) | 2003-07-10 | 2005-01-13 | Claus Herdeis | Method of treatment for acne, rosacea and ulcers with taurolidine and/or taurultam in a pharmaceutical composition |
| US7258875B2 (en) | 2003-12-04 | 2007-08-21 | Chiou Consulting, Inc. | Compositions and methods for topical treatment of skin infection |
| EP1720515A1 (en) * | 2004-03-02 | 2006-11-15 | GIULIANI S.p.A. | Composition for regulating the trophism of hair follicles and the cutaneous production of sebum and use thereof in androgenetic alopecia |
| US20060193922A1 (en) | 2005-02-25 | 2006-08-31 | Natalia Neikrug | Compositions and methods for the treatment of acne |
| US7955610B2 (en) | 2005-08-04 | 2011-06-07 | National Science And Technology Development Agency | Antimicrobial composition for topical application and a method thereof |
| AR062334A1 (es) | 2006-08-11 | 2008-10-29 | Panacea Biotec Ltd | Particulas para suministrar ingredientes activos, proceso para hacerlas y composiciones de las mismas |
| JP2011528377A (ja) * | 2008-07-17 | 2011-11-17 | レヴィス，ジョージア | 座瘡治療のための方法及び物質 |
| PL2418945T3 (pl) * | 2009-04-15 | 2019-05-31 | Bmg Pharma S P A | Kompozycje soli mineralnej - kwasu sulfonowego i sposoby ich stosowania |
| US20140121188A1 (en) | 2009-10-02 | 2014-05-01 | Foamix Ltd. | Compositions for the improved treatment of acne and related disorders |
| KR20170018852A (ko) * | 2014-07-01 | 2017-02-20 | 엔리케 샤콘 | 상처 치료를 위한 국소 조성물 및 방법 |
| CA2987293C (en) * | 2015-06-17 | 2020-11-03 | Margaret Jean Profet | Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne |
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| US10342823B2 (en) | 2019-07-09 |
| JP6657394B2 (ja) | 2020-03-04 |
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| JP2020073587A (ja) | 2020-05-14 |
| KR102055492B1 (ko) | 2019-12-12 |
| MX2017015012A (es) | 2018-08-15 |
| US9795633B2 (en) | 2017-10-24 |
| US20180036340A1 (en) | 2018-02-08 |
| KR20180004202A (ko) | 2018-01-10 |
| AU2016278939B2 (en) | 2018-11-08 |
| MX365366B (es) | 2019-05-30 |
| US20160367596A1 (en) | 2016-12-22 |
| EP3310366A1 (en) | 2018-04-25 |
| WO2016205089A1 (en) | 2016-12-22 |
| AU2016278939A1 (en) | 2017-12-07 |
| CA2987293A1 (en) | 2016-12-22 |
| EP3310366A4 (en) | 2019-01-02 |
| CN107708708A (zh) | 2018-02-16 |
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