CA2986314C - Methods for improving functionality in nk cell by gene inactivation using specific endonuclease - Google Patents

Methods for improving functionality in nk cell by gene inactivation using specific endonuclease Download PDF

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CA2986314C
CA2986314C CA2986314A CA2986314A CA2986314C CA 2986314 C CA2986314 C CA 2986314C CA 2986314 A CA2986314 A CA 2986314A CA 2986314 A CA2986314 A CA 2986314A CA 2986314 C CA2986314 C CA 2986314C
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cells
cell
gene
receptor
engineered
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CA2986314A1 (en
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Julien Valton
Philippe Duchateau
Jean-Pierre CARBANIOLS
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Cellectis SA
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Cellectis SA
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2510/00—Genetically modified cells

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  • General Chemical & Material Sciences (AREA)
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  • Communicable Diseases (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CA2986314A 2015-06-30 2016-06-30 Methods for improving functionality in nk cell by gene inactivation using specific endonuclease Active CA2986314C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570408 2015-06-30
DKPA201570408 2015-06-30
PCT/EP2016/065326 WO2017001572A1 (en) 2015-06-30 2016-06-30 Methods for improving functionality in nk cell by gene inactivation using specific endonuclease

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CA2986314A1 CA2986314A1 (en) 2017-01-05
CA2986314C true CA2986314C (en) 2024-04-23

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US (1) US20180171298A1 (cg-RX-API-DMAC10.html)
EP (2) EP3317399B1 (cg-RX-API-DMAC10.html)
JP (2) JP7033453B2 (cg-RX-API-DMAC10.html)
AU (1) AU2016287440B2 (cg-RX-API-DMAC10.html)
CA (1) CA2986314C (cg-RX-API-DMAC10.html)
WO (1) WO2017001572A1 (cg-RX-API-DMAC10.html)

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