CA2983434A1 - Sous-ensemble de cellules nkt pour la persistance et l'activite therapeutique in vivo et propagation de celui-ci - Google Patents
Sous-ensemble de cellules nkt pour la persistance et l'activite therapeutique in vivo et propagation de celui-ciInfo
- Publication number
- CA2983434A1 CA2983434A1 CA2983434A CA2983434A CA2983434A1 CA 2983434 A1 CA2983434 A1 CA 2983434A1 CA 2983434 A CA2983434 A CA 2983434A CA 2983434 A CA2983434 A CA 2983434A CA 2983434 A1 CA2983434 A1 CA 2983434A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- cd62l
- nkt cells
- nkts
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
Des modes de réalisation de l'invention comprennent des procédés et des compositions destinés à produire des cellules NKT efficaces pour l'immunothérapie et l'invention concerne également des procédés et des compositions permettant de fournir une quantité efficace de cellules NKT à un individu ayant besoin d'une immunothérapie. Dans des modes de réalisation spécifiques, les cellules NKT sont des CD62L+ et ont été exposées à un ou plusieurs agents de co-stimulation pour maintenir l'expression de CD62L. Les cellules NKT peuvent être modifiées pour incorporer un récepteur d'antigène chimère, dans certains cas.
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| US201562151690P | 2015-04-23 | 2015-04-23 | |
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| US201662309525P | 2016-03-17 | 2016-03-17 | |
| US62/309,525 | 2016-03-17 | ||
| PCT/US2016/028693 WO2016172372A1 (fr) | 2015-04-23 | 2016-04-21 | Sous-ensemble de cellules nkt pour la persistance et l'activité thérapeutique in vivo et propagation de celui-ci |
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| CA2983434A1 true CA2983434A1 (fr) | 2016-10-27 |
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| HK (1) | HK1252164A1 (fr) |
| SG (1) | SG11201708600RA (fr) |
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| CN106434556B (zh) * | 2016-11-22 | 2019-10-11 | 上海新长安生物科技有限公司 | 一种体外诱导扩增i型nkt细胞的方法 |
| EP3441461A1 (fr) * | 2017-08-11 | 2019-02-13 | Baylor College of Medicine | Cellules nkt appauvries en cd1d comme une plate-forme pour le immunothérapie du cancer standard |
| JP2021520184A (ja) * | 2017-09-29 | 2021-08-19 | ナントセル，インコーポレイテッド | Ｃｄ１ｄ及びｔｃｒ−ｎｋｔ細胞 |
| EP3801568A4 (fr) * | 2018-05-31 | 2022-03-16 | Washington University | Cellules t tueuses naturelles invariantes à édition génomique pour le traitement de malignités hématologiques |
| CN109402053A (zh) * | 2018-10-17 | 2019-03-01 | 广州元帅生物科技有限公司 | 一种外周血来源单个核细胞的分离及诱导培养方法 |
| EP4011389A1 (fr) * | 2019-08-09 | 2022-06-15 | Riken | Utilisation combinée de cellules vecteur adjuvant artificiel et d'immunostimulant |
| US20220249562A1 (en) * | 2019-08-21 | 2022-08-11 | Akeso Therapeutics, Inc. | Type iii nkt cells and related compositions and methods |
| JP2023500671A (ja) * | 2019-11-06 | 2023-01-10 | ベイラー カレッジ オブ メディスン | がんのｔ細胞治療のための細胞傷害性エフェクターメモリーｔ細胞の産生方法 |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
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| EP3785712A1 (fr) * | 2009-12-29 | 2021-03-03 | Gamida-Cell Ltd. | Procédés de renforcement de la prolifération et de l'activité de cellules tueuses naturelles |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US9487800B2 (en) | 2010-09-08 | 2016-11-08 | Chemotherapeutisches Forschunginstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| US8741642B2 (en) * | 2010-10-22 | 2014-06-03 | Virginia Commonwealth University | Methods for producing autologous immune cells resistant to myeloid-derived suppressor cells effects |
| CA2781954A1 (fr) | 2011-06-28 | 2012-12-28 | F2M International Inc. | Support a tuyau |
| WO2013040371A2 (fr) * | 2011-09-16 | 2013-03-21 | Baylor College Of Medicine | Ciblage du microenvironnement tumoral au moyen de cellules nkt modifiées |
| US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| JP2015513399A (ja) * | 2012-02-22 | 2015-05-14 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 癌の治療のために有用なｔ細胞の存続的集団を作製するための組成物および方法 |
| WO2013142255A2 (fr) * | 2012-03-22 | 2013-09-26 | University Of Miami | Agents de liaison multi-spécifiques |
| US20160017302A1 (en) * | 2013-03-05 | 2016-01-21 | Baylor College Of Medicine | Heparanase expression in human t lymphocytes |
| EP3052085B1 (fr) | 2013-10-03 | 2019-07-03 | University of Maryland, Baltimore | Activation de cellules nkt médiée par des cellules présentatrices de l'antigène artificielles à base de nanoparticules |
| CA2938887C (fr) | 2014-02-14 | 2023-04-11 | Laurence J. N. Cooper | Recepteurs antigeniques chimeriques et procede de production |
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| US20180264040A1 (en) | 2018-09-20 |
| US11458168B2 (en) | 2022-10-04 |
| JP2022058482A (ja) | 2022-04-12 |
| US20160310532A1 (en) | 2016-10-27 |
| HK1252164A1 (zh) | 2019-05-17 |
| JP7086375B2 (ja) | 2022-06-20 |
| WO2016172372A1 (fr) | 2016-10-27 |
| CN107847585A (zh) | 2018-03-27 |
| CN115747156A (zh) | 2023-03-07 |
| EP3291835A1 (fr) | 2018-03-14 |
| US20200163992A1 (en) | 2020-05-28 |
| SG11201708600RA (en) | 2017-11-29 |
| AU2022201744A1 (en) | 2022-04-07 |
| EP3291835A4 (fr) | 2019-01-23 |
| US11266689B2 (en) | 2022-03-08 |
| JP2018516548A (ja) | 2018-06-28 |
| CN107847585B (zh) | 2022-09-23 |
| KR20180021683A (ko) | 2018-03-05 |
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