CA2982536C - Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a - Google Patents

Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a Download PDF

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Publication number
CA2982536C
CA2982536C CA2982536A CA2982536A CA2982536C CA 2982536 C CA2982536 C CA 2982536C CA 2982536 A CA2982536 A CA 2982536A CA 2982536 A CA2982536 A CA 2982536A CA 2982536 C CA2982536 C CA 2982536C
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Canada
Prior art keywords
seq
antibody
amino acids
sample
peptide
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CA2982536A
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English (en)
French (fr)
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CA2982536A1 (en
Inventor
Fernando Jose Rebelo Do Couto
Zhiming Liao
Yifei Zhu
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Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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Publication of CA2982536A1 publication Critical patent/CA2982536A1/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Oncology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2982536A 2015-04-17 2016-04-13 Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a Active CA2982536C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562149239P 2015-04-17 2015-04-17
US62/149,239 2015-04-17
PCT/EP2016/058135 WO2016166169A1 (en) 2015-04-17 2016-04-13 Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a

Publications (2)

Publication Number Publication Date
CA2982536A1 CA2982536A1 (en) 2016-10-20
CA2982536C true CA2982536C (en) 2023-04-18

Family

ID=55702016

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2982536A Active CA2982536C (en) 2015-04-17 2016-04-13 Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a

Country Status (6)

Country Link
US (2) US10948493B2 (enExample)
EP (1) EP3283522A1 (enExample)
JP (1) JP6720208B2 (enExample)
AU (1) AU2016249839B2 (enExample)
CA (1) CA2982536C (enExample)
WO (1) WO2016166169A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2982536C (en) * 2015-04-17 2023-04-18 Spring Bioscience Corporation Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a
CN111349164B (zh) * 2018-12-21 2023-05-26 艾比玛特医药科技（上海）有限公司 糖基磷脂酰肌醇锚定糖蛋白（c4.4a）的单克隆抗体及其应用
CN117693348A (zh) * 2021-06-11 2024-03-12 纪念斯隆-凯特琳癌症中心 靶向uPAR的抗原识别受体和其用途
AU2023234686A1 (en) * 2022-03-16 2024-08-29 Pentixapharm Ag Antibodies against lypd3
EP4536278A4 (en) 2022-06-07 2026-08-12 Actinium Pharmaceuticals Inc CHELETARIANS AND BIFUNCTIONAL CONJUGATES
CN116086919B (zh) * 2023-02-20 2024-01-26 深圳裕策生物科技有限公司 一种肺癌和/或胰腺癌样本的染色方法及试剂盒
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1220919A2 (en) 1999-09-29 2002-07-10 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Metastasis-associated antigen c4.4a
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US20020083888A1 (en) 2000-12-28 2002-07-04 Zehnder Donald A. Flow synthesis of quantum dot nanocrystals
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
EP2218762A3 (en) 2001-07-20 2010-09-29 Life Technologies Corporation Luminescent nanoparticles and methods for their preparation
AU2003210060B2 (en) 2002-03-22 2010-02-25 Aprogen, Inc. Humanized antibody and process for preparing same
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
ES2330441T3 (es) 2003-06-24 2009-12-10 Ventana Medical Systems, Inc. Deposito de metal catalizado por una enzima para la deteccion in situ mejorada de epitopos inmunohistoquimicos y secuencias de acido nucleico.
EP3276349B1 (en) 2006-11-01 2019-08-07 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
NZ601583A (en) * 2007-05-21 2013-08-30 Bristol Myers Squibb Co Novel rabbit antibody humanization methods and humanized rabbit antibodies
EP2535350B1 (en) * 2007-09-26 2018-01-24 UCB Biopharma SPRL Dual specificity antibody fusions
MX2012006593A (es) * 2009-12-09 2012-06-28 Bayer Pharma AG Anticuerpos anti-c4.4a y usos de los mismos.
WO2011158883A1 (ja) * 2010-06-15 2011-12-22 国立大学法人大阪大学 癌予後判定可能な抗体、および癌予後判定方法
SG194567A1 (en) * 2011-04-21 2013-12-30 Seattle Genetics Inc Novel binder-drug conjugates (adcs) and their use
WO2012149299A2 (en) * 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
US20120295803A1 (en) 2011-05-16 2012-11-22 The Regents Of The University Of Michigan Lung cancer signature
CA2875451A1 (en) 2012-06-08 2013-12-12 Kinki University Antibody against transporter and use thereof
WO2014183119A1 (en) 2013-05-10 2014-11-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Molecular imaging probes for lung cancer inoperative guidance
CA2922704A1 (en) * 2013-05-24 2014-11-27 Neil R. Cashman Cell senescence markers as diagnostic and therapeutic targets
JP2017534251A (ja) * 2014-09-09 2017-11-24 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ａｇｒ２およびその受容体ｃ４．４ａに対する遮断モノクローナル抗体
CA2982536C (en) * 2015-04-17 2023-04-18 Spring Bioscience Corporation Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a

Also Published As

Publication number Publication date
AU2016249839A1 (en) 2017-09-21
US10948493B2 (en) 2021-03-16
WO2016166169A1 (en) 2016-10-20
EP3283522A1 (en) 2018-02-21
US11719699B2 (en) 2023-08-08
AU2016249839B2 (en) 2021-09-09
JP6720208B2 (ja) 2020-07-08
US20210164985A1 (en) 2021-06-03
US20180031566A1 (en) 2018-02-01
JP2018515071A (ja) 2018-06-14
CA2982536A1 (en) 2016-10-20

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