CA2982269C - Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same - Google Patents

Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same Download PDF

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Publication number
CA2982269C
CA2982269C CA2982269A CA2982269A CA2982269C CA 2982269 C CA2982269 C CA 2982269C CA 2982269 A CA2982269 A CA 2982269A CA 2982269 A CA2982269 A CA 2982269A CA 2982269 C CA2982269 C CA 2982269C
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nwc
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English (en)
French (fr)
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CA2982269A1 (en
Inventor
Christopher Martin Waldmann
Anton A. Toutov
Jennifer Marie Murphy
Robert H. Grubbs
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California Institute of Technology
University of California San Diego UCSD
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California Institute of Technology
University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2982269A 2015-05-26 2016-05-24 Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same Active CA2982269C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562166240P 2015-05-26 2015-05-26
US62/166,240 2015-05-26
PCT/US2016/033923 WO2016191424A2 (en) 2015-05-26 2016-05-24 Novel heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same

Publications (2)

Publication Number Publication Date
CA2982269A1 CA2982269A1 (en) 2016-12-01
CA2982269C true CA2982269C (en) 2023-12-05

Family

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Application Number Title Priority Date Filing Date
CA2982269A Active CA2982269C (en) 2015-05-26 2016-05-24 Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same

Country Status (6)

Country Link
US (4) US10800797B2 (https=)
EP (1) EP3303349B1 (https=)
JP (2) JP7266365B2 (https=)
CN (1) CN107667109B (https=)
CA (1) CA2982269C (https=)
WO (1) WO2016191424A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107667109B (zh) 2015-05-26 2021-08-03 加利福尼亚大学董事会 可用于分子和生物分子的18f标记的新的杂芳族硅-氟化物-受体及其制备方法
EA202090370A1 (ru) * 2017-07-28 2020-05-25 Технише Универзитет Мюнхен Двухрежимная радиоактивная метка и радиотерапевтическое средство
US11464784B2 (en) 2017-09-15 2022-10-11 The Regents Of The University Of California Inhibition of aminocylase 3 (AA3) in the treatment of cancer
CN113677375B (zh) * 2019-01-30 2024-07-23 慕尼黑工业大学 氟化硅受体取代的放射性药物及其前体
WO2020220020A1 (en) * 2019-04-26 2020-10-29 The Regents Of The University Of California Silicon-fluoride heteroaromatic systems for applications in positron emission tomography (pet) molecular imaging
CN114206937B (zh) * 2019-05-24 2025-06-03 杜克大学 18f放射性标记的生物分子
WO2021243337A1 (en) * 2020-05-29 2021-12-02 Fuzionaire. Inc. Methods for rapid formation of chemicals including positron emission tomography biomarkers
CA3249624A1 (en) * 2022-04-20 2023-10-26 Fuzionaire Theranostics, Inc. HETEROAROMATIC SYSTEMS OF THERANOSTIC SILICON FLUORIDE AND ASSOCIATED METHODS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972336B2 (en) * 2002-07-18 2005-12-06 Novartis Ag N-alkylation of indole derivatives
US20090035215A1 (en) 2006-10-02 2009-02-05 Ananth Srinivasan Radiofluorination
US20120046242A1 (en) * 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
CA3159948A1 (en) * 2010-12-22 2012-07-19 General Electric Company Radiolabled her2 binding peptides
CN107667109B (zh) * 2015-05-26 2021-08-03 加利福尼亚大学董事会 可用于分子和生物分子的18f标记的新的杂芳族硅-氟化物-受体及其制备方法

Also Published As

Publication number Publication date
US20180346491A1 (en) 2018-12-06
US10800797B2 (en) 2020-10-13
US11447508B2 (en) 2022-09-20
CN107667109A (zh) 2018-02-06
CN107667109B (zh) 2021-08-03
US12371445B2 (en) 2025-07-29
US20230114064A1 (en) 2023-04-13
JP2021073293A (ja) 2021-05-13
WO2016191424A2 (en) 2016-12-01
WO2016191424A3 (en) 2016-12-29
US20200377529A1 (en) 2020-12-03
EP3303349A2 (en) 2018-04-11
JP7266365B2 (ja) 2023-04-28
US20250333425A1 (en) 2025-10-30
EP3303349B1 (en) 2022-07-06
EP3303349A4 (en) 2019-03-13
CA2982269A1 (en) 2016-12-01
JP2018521956A (ja) 2018-08-09

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