CA2970108C - Oligopeptide tyrosinase inhibitors and uses thereof - Google Patents
Oligopeptide tyrosinase inhibitors and uses thereof Download PDFInfo
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- CA2970108C CA2970108C CA2970108A CA2970108A CA2970108C CA 2970108 C CA2970108 C CA 2970108C CA 2970108 A CA2970108 A CA 2970108A CA 2970108 A CA2970108 A CA 2970108A CA 2970108 C CA2970108 C CA 2970108C
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- peptide
- tyrosinase
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- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 229940051117 tri-luma Drugs 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- ATTPXNCCXYEULE-JOBJWGHLSA-N triluma Chemical compound OC1=CC=C(O)C=C1.OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O ATTPXNCCXYEULE-JOBJWGHLSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000037997 venous disease Diseases 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93739207P | 2007-06-27 | 2007-06-27 | |
| US60/937,392 | 2007-06-27 | ||
| CA2728122A CA2728122C (en) | 2007-06-27 | 2008-06-25 | Oligopeptide tyrosinase inhibitors and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2728122A Division CA2728122C (en) | 2007-06-27 | 2008-06-25 | Oligopeptide tyrosinase inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2970108A1 CA2970108A1 (en) | 2008-12-31 |
| CA2970108C true CA2970108C (en) | 2020-04-07 |
Family
ID=40186021
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2970108A Active CA2970108C (en) | 2007-06-27 | 2008-06-25 | Oligopeptide tyrosinase inhibitors and uses thereof |
| CA2728122A Active CA2728122C (en) | 2007-06-27 | 2008-06-25 | Oligopeptide tyrosinase inhibitors and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2728122A Active CA2728122C (en) | 2007-06-27 | 2008-06-25 | Oligopeptide tyrosinase inhibitors and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7902329B2 (OSRAM) |
| EP (1) | EP2173370B1 (OSRAM) |
| JP (2) | JP5587772B2 (OSRAM) |
| KR (2) | KR101561709B1 (OSRAM) |
| CN (2) | CN101795702B (OSRAM) |
| CA (2) | CA2970108C (OSRAM) |
| WO (1) | WO2009003034A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6641591B1 (en) | 1999-08-26 | 2003-11-04 | John H. Shadduck | Instruments and techniques for controlled removal of epidermal layers |
| US8048089B2 (en) | 2005-12-30 | 2011-11-01 | Edge Systems Corporation | Apparatus and methods for treating the skin |
| US9566088B2 (en) | 2006-03-29 | 2017-02-14 | Edge Systems Llc | Devices, systems and methods for treating the skin |
| WO2014151104A1 (en) | 2013-03-15 | 2014-09-25 | Edge Systems Llc | Devices, systems and methods for treating the skin |
| US10172644B2 (en) | 2006-03-29 | 2019-01-08 | Edge Systems Llc | Devices, systems and methods for treating the skin |
| KR20100129269A (ko) | 2008-01-04 | 2010-12-08 | 엣지 시스템즈 코포레이션 | 피부 처리 장치 및 방법 |
| US9056193B2 (en) | 2008-01-29 | 2015-06-16 | Edge Systems Llc | Apparatus and method for treating the skin |
| EP2451367B1 (en) | 2009-07-08 | 2020-01-22 | Edge Systems Corporation | Devices for treating the skin using time-release substances |
| WO2011116072A1 (en) | 2010-03-16 | 2011-09-22 | Escape Therapeutics, Inc. | Hybrid hydrogel scaffold compositions and methods of use |
| EP2382963A1 (en) * | 2010-04-29 | 2011-11-02 | Cognis IP Management GmbH | Cosmetic composition containing oligopeptides |
| CN102492018A (zh) * | 2010-07-27 | 2012-06-13 | 萧乃文 | 酪氨酸酶多肽抑制剂 |
| US10238812B2 (en) | 2013-03-15 | 2019-03-26 | Edge Systems Llc | Skin treatment systems and methods using needles |
| US9567368B2 (en) * | 2013-11-29 | 2017-02-14 | Escape Therapeutics, Inc. | Peptide tyrosinase activators |
| EP2990027A1 (en) | 2014-09-01 | 2016-03-02 | Institut Curie | Skin whitening peptide agents |
| EP3795204B1 (en) | 2014-12-23 | 2023-10-25 | HydraFacial LLC | Device for treating the skin using a rollerball |
| US10179229B2 (en) | 2014-12-23 | 2019-01-15 | Edge Systems Llc | Devices and methods for treating the skin using a porous member |
| KR102628349B1 (ko) | 2015-07-08 | 2024-01-24 | 하이드라페이셜 엘엘씨 | 모발 성장을 촉진하기 위한 디바이스, 시스템 및 방법 |
| CN105177092A (zh) * | 2015-09-23 | 2015-12-23 | 华侨大学 | 一种具有美白功效的活性多肽的生物发酵制备方法 |
| WO2018183882A1 (en) * | 2017-03-30 | 2018-10-04 | Escape Therapeutics, Inc. | Decapeptide-12 modulation of sirtuin gene expression in epidermal keratinocyte progenitors |
| CN107253977B (zh) * | 2017-07-03 | 2020-04-28 | 大连理工大学 | 抑制黑色素生成抗氧化的小肽、制备方法及其应用 |
| CN108837142A (zh) * | 2018-07-20 | 2018-11-20 | 厦门艾赛生物科技有限公司 | 一种可修复皮肤的干细胞外泌体及其制备方法和应用 |
| JP7241483B2 (ja) * | 2018-07-23 | 2023-03-17 | 株式会社ノエビア | 皮膚用組成物 |
| CN108948151B (zh) * | 2018-08-06 | 2019-06-21 | 山西锦波生物医药股份有限公司 | 肽及其制备方法和用途 |
| MX2020014330A (es) * | 2018-12-26 | 2021-03-09 | Caregen Co Ltd | Composicion para relajacion muscular. |
| KR20250145122A (ko) * | 2019-01-19 | 2025-10-13 | 이스케이프 테라퓨틱스, 인코퍼레이티드 | 인간 신생아 각질형성세포 전구체에서 면역억제 활성을 갖는 티로신 억제제 |
| EP3930740A4 (en) * | 2019-02-25 | 2022-12-21 | Topix Pharmaceuticals, Inc. | METHODS, COMPOSITIONS, FILMS FOR THERAPEUTIC SKIN TREATMENTS |
| US11291474B2 (en) | 2020-01-06 | 2022-04-05 | Ed F. Nicolas | Skin treatment tool applicator tip |
| KR20230091927A (ko) * | 2020-10-20 | 2023-06-23 | 이스케이프 테라퓨틱스, 인코퍼레이티드 | 구조적 변형, 화학적 증진 및 마이크로니들에 의한 신규 펩타이드의 피부 침투성 증진 |
| KR102506020B1 (ko) * | 2020-11-27 | 2023-03-06 | 웰펩 주식회사 | 항산화 활성 및 티로시나제 저해활성을 갖는 펩타이드 및 이를 포함하는 조성물 |
| USD1016615S1 (en) | 2021-09-10 | 2024-03-05 | Hydrafacial Llc | Container for a skin treatment device |
| USD1065551S1 (en) | 2021-09-10 | 2025-03-04 | Hydrafacial Llc | Skin treatment device |
| USD1042807S1 (en) | 2021-10-11 | 2024-09-17 | Hydrafacial Llc | Skin treatment tip |
| USD1084369S1 (en) | 2023-02-10 | 2025-07-15 | Hydrafacial Llc | Skin treatment tip |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3755560A (en) * | 1971-06-30 | 1973-08-28 | Dow Chemical Co | Nongreasy cosmetic lotions |
| US3978427A (en) * | 1973-06-15 | 1976-08-31 | American Optical Corporation | Erbium laser device having non-masking laser rod holders |
| US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4421769A (en) * | 1981-09-29 | 1983-12-20 | The Procter & Gamble Company | Skin conditioning composition |
| IT1164225B (it) * | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| EP0389950A1 (en) * | 1989-03-23 | 1990-10-03 | Lion Corporation | Melanocyte-stimulating hormone inhibitor and external preparation containing the same |
| US5773291A (en) * | 1989-04-26 | 1998-06-30 | Sloan-Kettering Institute For Cancer Research | Non-melanotytic mammalian cell constitutively expressing biologically active human tyrosinase and use thereof |
| JPH06505701A (ja) * | 1990-09-10 | 1994-06-30 | スクール・オブ・フアーマシー・ユニバーシテイ・オブ・ロンドン | リポソーム |
| US5543389A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| AU1194092A (en) * | 1991-02-06 | 1992-09-07 | Georgetown University | Receptor blocking peptides of fibroblast growth factor receptor |
| US5455228A (en) * | 1993-07-02 | 1995-10-03 | The Research Foundation Of State University Of New York | Peptidase resistant thrombin receptor peptide ligand |
| US5589460A (en) * | 1994-05-04 | 1996-12-31 | Innapharma, Inc. | Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent |
| US6602856B1 (en) * | 1995-01-17 | 2003-08-05 | J. Mark Quillan | Antagonists of alpha-melanocyte stimulating hormone and methods based thereon |
| WO1996028471A1 (en) * | 1995-03-14 | 1996-09-19 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
| BR9708390A (pt) * | 1996-03-28 | 2000-01-04 | Trustees O Boston University | Método para identificar uma substância que altera a pigmentação nos melanócitos epidérmicos de vertebrados, substância que inibe, intensifica ou modula a fosforização da tirosinase mediada pela proteìna c-beta quinase, uso de um agente que modula ou inibe a fosforização de um resìduo de serina ou de treonina mediada pela proteìna c-beta quinase, uso em peptìdeo que especificamente interfere na fosforização de resìduos de serina/treonina mediada pela proteìna c-beta quinase, uso de uma construção de dna ou de um peptìdeo para fabricar um medicamento para diminuir a pigmentação na pela, cabelo, lã ou pelo de vertebrados e uso de uma substância que modula a fosforização da tirosinase mediada pela proteìna c-beta quinase. |
| US6143723A (en) * | 1996-05-20 | 2000-11-07 | Ramaiah; Abburi | Pigmentory agent |
| KR100478928B1 (ko) * | 1996-11-08 | 2005-08-18 | 세이렌가부시끼가이샤 | 세리신또는세리신가수분해물을유효성분으로하는비의약용항산화제,화장품,식품변색방지제,음식물,심근경색치료제,동맥경화치료제,당뇨병치료제,암치료제,또는뇌줄중치료제 |
| US6982249B1 (en) * | 1997-04-23 | 2006-01-03 | The Regents Of The University Of Michigan | Bradykinin analogs as selective inhibitors of cell activation |
| US6368877B1 (en) | 1997-06-25 | 2002-04-09 | Massachusetts Institute Of Technology | Self-assembling peptide surfaces for cell patterning and interactions |
| US6287590B1 (en) * | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
| US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| US6323219B1 (en) * | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
| US6663659B2 (en) * | 2000-01-13 | 2003-12-16 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US20020034772A1 (en) * | 1999-06-29 | 2002-03-21 | Orlow Seth J. | Methods and compositions that affect melanogenesis |
| US7083781B2 (en) * | 1999-08-19 | 2006-08-01 | Lavipharm S.A. | Film forming polymers, methods of use, and devices and applications thereof |
| US6283978B1 (en) * | 2000-06-09 | 2001-09-04 | Peter J. Cheski | Method and apparatus for microdermabrasion |
| PL363153A1 (en) * | 2000-06-16 | 2004-11-15 | Hercules Incorporated | Chemically-modified antimicrobial peptides, compositions and methods of production and use |
| US20020182237A1 (en) * | 2001-03-22 | 2002-12-05 | The Procter & Gamble Company | Skin care compositions containing a sugar amine |
| US20020192738A1 (en) * | 2001-04-27 | 2002-12-19 | Janice Brissette | Tyrosinase assay |
| US7658742B2 (en) * | 2001-11-21 | 2010-02-09 | Envy Medical, Inc. | Skin treatment system and method of use |
| US6695853B2 (en) | 2001-11-21 | 2004-02-24 | Emed, Inc. | Microdermabrasion system and method of use |
| US6649150B2 (en) * | 2002-04-11 | 2003-11-18 | Em Industries | Skin-lightening |
| US7025957B2 (en) * | 2002-09-06 | 2006-04-11 | Desert Whale Jojoba Company | Composition and method to whiten skin |
| US7125572B2 (en) * | 2004-05-14 | 2006-10-24 | Kaoder Industry Company, Ltd. | Tyrosinase inhibitor extract |
| EP1913157B2 (en) | 2005-06-28 | 2016-10-26 | Genentech, Inc. | Egfr and kras mutations for prediction of patient response to egfr inhibitor treatment |
| FR2890859B1 (fr) | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
-
2008
- 2008-06-25 JP JP2010515076A patent/JP5587772B2/ja active Active
- 2008-06-25 CN CN200880104997.8A patent/CN101795702B/zh active Active
- 2008-06-25 EP EP08771924.1A patent/EP2173370B1/en active Active
- 2008-06-25 CA CA2970108A patent/CA2970108C/en active Active
- 2008-06-25 US US12/146,070 patent/US7902329B2/en active Active
- 2008-06-25 CA CA2728122A patent/CA2728122C/en active Active
- 2008-06-25 KR KR1020107001770A patent/KR101561709B1/ko active Active
- 2008-06-25 WO PCT/US2008/068181 patent/WO2009003034A1/en not_active Ceased
- 2008-06-25 KR KR1020157017755A patent/KR20150083931A/ko not_active Withdrawn
- 2008-06-25 CN CN201410319956.8A patent/CN104083752B/zh active Active
-
2010
- 2010-12-21 US US12/975,030 patent/US8193154B2/en active Active
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2014
- 2014-04-03 JP JP2014077171A patent/JP2014159442A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2728122A1 (en) | 2008-12-31 |
| CN104083752A (zh) | 2014-10-08 |
| CN104083752B (zh) | 2018-04-10 |
| US7902329B2 (en) | 2011-03-08 |
| CA2970108A1 (en) | 2008-12-31 |
| KR101561709B1 (ko) | 2015-10-22 |
| US8193154B2 (en) | 2012-06-05 |
| US20110091530A1 (en) | 2011-04-21 |
| JP2014159442A (ja) | 2014-09-04 |
| WO2009003034A1 (en) | 2008-12-31 |
| JP2011504165A (ja) | 2011-02-03 |
| KR20150083931A (ko) | 2015-07-20 |
| EP2173370A4 (en) | 2012-03-07 |
| EP2173370B1 (en) | 2015-10-21 |
| EP2173370A1 (en) | 2010-04-14 |
| JP5587772B2 (ja) | 2014-09-10 |
| KR20100109890A (ko) | 2010-10-11 |
| WO2009003034A8 (en) | 2010-09-16 |
| US20090099091A1 (en) | 2009-04-16 |
| CN101795702B (zh) | 2014-08-06 |
| CN101795702A (zh) | 2010-08-04 |
| CA2728122C (en) | 2017-07-25 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20170607 |