CA2969597C - 1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors - Google Patents

1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors Download PDF

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CA2969597C
CA2969597C CA2969597A CA2969597A CA2969597C CA 2969597 C CA2969597 C CA 2969597C CA 2969597 A CA2969597 A CA 2969597A CA 2969597 A CA2969597 A CA 2969597A CA 2969597 C CA2969597 C CA 2969597C
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disorder
pyrazolo
butoxy
methy1
naphthyridin
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French (fr)
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CA2969597A1 (en
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Peng Li
Hailin Zheng
Gretchen Snyder
Lawrence P. Wennogle
Joseph Hendrick
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Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2969597A 2014-12-06 2015-12-07 1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors Active CA2969597C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088540P 2014-12-06 2014-12-06
US62/088,540 2014-12-06
PCT/US2015/064331 WO2016090382A1 (en) 2014-12-06 2015-12-07 Organic compounds

Publications (2)

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CA2969597A1 CA2969597A1 (en) 2016-06-09
CA2969597C true CA2969597C (en) 2023-10-24

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CA2969597A Active CA2969597C (en) 2014-12-06 2015-12-07 1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors

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US (2) US10105349B2 (enExample)
EP (1) EP3226862B1 (enExample)
JP (1) JP6608933B2 (enExample)
KR (1) KR102562576B1 (enExample)
CN (1) CN107205993B (enExample)
AU (1) AU2015357498B2 (enExample)
BR (1) BR112017012005B1 (enExample)
CA (1) CA2969597C (enExample)
HK (2) HK1243935A1 (enExample)
IL (1) IL252578B (enExample)
MX (1) MX373320B (enExample)
RU (1) RU2702732C1 (enExample)
WO (1) WO2016090382A1 (enExample)

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TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
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CN112851667B (zh) * 2019-11-28 2022-09-09 暨南大学 含氮并杂环类化合物及其药用组合物和应用
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