CA2968310A1 - 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators - Google Patents

6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators Download PDF

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Publication number
CA2968310A1
CA2968310A1 CA2968310A CA2968310A CA2968310A1 CA 2968310 A1 CA2968310 A1 CA 2968310A1 CA 2968310 A CA2968310 A CA 2968310A CA 2968310 A CA2968310 A CA 2968310A CA 2968310 A1 CA2968310 A1 CA 2968310A1
Authority
CA
Canada
Prior art keywords
general formula
alkyl
compound
halo
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2968310A
Other languages
English (en)
French (fr)
Inventor
Alexander Weymouth-Wilson
Zofia KOMSTA
James Boydell
Laura WALLIS
Carl OTTER
Ieuan DAVIES
Rob CLARKSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nzp Uk Ltd
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505675.7A external-priority patent/GB201505675D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of CA2968310A1 publication Critical patent/CA2968310A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2968310A 2014-11-19 2015-11-19 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators Abandoned CA2968310A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GB1420594.2 2014-11-19
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505675.7A GB201505675D0 (en) 2015-04-01 2015-04-01 Compounds
GB1505675.7 2015-04-01
PCT/GB2015/053519 WO2016079520A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
CA2968310A1 true CA2968310A1 (en) 2016-05-26

Family

ID=54704022

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968310A Abandoned CA2968310A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators

Country Status (10)

Country Link
US (2) US20170327531A1 (https=)
EP (1) EP3221334B1 (https=)
JP (1) JP6698085B2 (https=)
KR (1) KR102527821B1 (https=)
CN (1) CN107207558B (https=)
CA (1) CA2968310A1 (https=)
EA (1) EA033603B1 (https=)
MX (1) MX381239B (https=)
TW (1) TWI688571B (https=)
WO (1) WO2016079520A1 (https=)

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KR102546748B1 (ko) 2014-11-19 2023-06-22 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
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GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
CN106046093A (zh) * 2016-05-30 2016-10-26 华东师范大学 一种石胆酸的合成方法
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN116178473B (zh) * 2018-12-10 2025-03-04 江西科睿药业有限公司 一种奥贝胆酸的制备方法

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Also Published As

Publication number Publication date
US20170327531A1 (en) 2017-11-16
TW201632539A (zh) 2016-09-16
US10597423B2 (en) 2020-03-24
EP3221334A1 (en) 2017-09-27
EA033603B1 (ru) 2019-11-08
JP6698085B2 (ja) 2020-05-27
KR102527821B1 (ko) 2023-05-02
HK1244286A1 (en) 2018-08-03
MX2017006567A (es) 2018-01-26
MX381239B (es) 2025-03-12
TWI688571B (zh) 2020-03-21
EA201790885A1 (ru) 2017-11-30
US20190077827A1 (en) 2019-03-14
JP2017534669A (ja) 2017-11-24
EP3221334B1 (en) 2020-02-19
KR20170099896A (ko) 2017-09-01
CN107207558A (zh) 2017-09-26
CN107207558B (zh) 2019-10-29
WO2016079520A1 (en) 2016-05-26

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210831