CA2966397A1 - Methods for generating bispecific shark variable antibody domains and use thereof - Google Patents
Methods for generating bispecific shark variable antibody domains and use thereof Download PDFInfo
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- CA2966397A1 CA2966397A1 CA2966397A CA2966397A CA2966397A1 CA 2966397 A1 CA2966397 A1 CA 2966397A1 CA 2966397 A CA2966397 A CA 2966397A CA 2966397 A CA2966397 A CA 2966397A CA 2966397 A1 CA2966397 A1 CA 2966397A1
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP14003700 | 2014-11-03 | ||
| EP14003700.3 | 2014-11-03 | ||
| PCT/EP2015/002086 WO2016070959A1 (en) | 2014-11-03 | 2015-10-21 | Methods for generating bispecific shark variable antibody domains and use thereof |
Publications (1)
| Publication Number | Publication Date |
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| CA2966397A1 true CA2966397A1 (en) | 2016-05-12 |
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| CA2966397A Abandoned CA2966397A1 (en) | 2014-11-03 | 2015-10-21 | Methods for generating bispecific shark variable antibody domains and use thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11001640B2 (show.php) |
| EP (1) | EP3215531A1 (show.php) |
| JP (1) | JP6734271B2 (show.php) |
| CN (1) | CN107074961A (show.php) |
| AU (1) | AU2015342264B2 (show.php) |
| CA (1) | CA2966397A1 (show.php) |
| IL (1) | IL252008A0 (show.php) |
| WO (1) | WO2016070959A1 (show.php) |
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| ES3049809T3 (en) | 2016-08-06 | 2025-12-18 | Ossianix Inc | In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use |
| IL268554B2 (en) | 2017-02-08 | 2025-03-01 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| FI3582806T3 (fi) | 2017-02-20 | 2023-09-07 | Dragonfly Therapeutics Inc | Her2:ta, nkg2d:tä ja cd16:ta sitovia proteiineja |
| SG10202102251YA (en) * | 2017-08-16 | 2021-04-29 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16, and egfr, hla-e ccr4, or pd-l1 |
| US11884733B2 (en) | 2018-02-08 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| KR20200118824A (ko) | 2018-02-08 | 2020-10-16 | 드래곤플라이 쎄라퓨틱스, 인크. | 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법 |
| JP7353576B2 (ja) | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
| MA53284A (fr) | 2018-08-08 | 2022-01-26 | Dragonfly Therapeutics Inc | Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| WO2020056327A1 (en) | 2018-09-14 | 2020-03-19 | Ossianix, Inc. | Tfr-specific binding moieties and transcytosis method to select vnars that cross cellular barriers |
| AR122018A1 (es) | 2020-05-06 | 2022-08-03 | Dragonfly Therapeutics Inc | Proteínas que se unen a nkg2d, cd16 y clec12a |
| CN112301431B (zh) * | 2020-08-12 | 2023-01-31 | 华东理工大学 | 基于鲨鱼抗体可变区v-nar的噬菌体文库及其构建方法 |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| CN112940120B (zh) * | 2021-05-14 | 2021-08-17 | 深圳海创生物技术有限公司 | 降钙素原单域抗体及其应用和试剂盒 |
| WO2023077287A1 (en) * | 2021-11-03 | 2023-05-11 | City university of hong kong shenzhen research institute | High-affinity anti-egfp and anti-sars-cov-2 vnar single domain antibodies and use thereof |
| CN115975010A (zh) * | 2022-08-31 | 2023-04-18 | 闽江学院 | 一种十足目虹彩病毒1的单域抗体及其制备方法和应用 |
| CN116143913A (zh) * | 2022-12-30 | 2023-05-23 | 闽江学院 | 一种结合SARS-CoV-2 RBD的鲨鱼源单域抗体及其制备方法和应用 |
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| ATE446771T1 (de) | 2001-05-24 | 2009-11-15 | Zymogenetics Inc | Taci-immunoglobulin-fusionsproteine |
| MX2012009460A (es) * | 2010-03-03 | 2012-09-12 | Boehringer Ingelheim Int | Polipeptidos biparatopicos de union abeta. |
| CN103261220B (zh) * | 2010-08-16 | 2016-06-15 | 诺夫免疫股份有限公司 | 用于生成多特异性和多价抗体的方法 |
| EP2847229B1 (en) | 2012-05-07 | 2022-09-07 | Elasmogen Limited | Single domain binding molecule |
| EP2989204B1 (en) * | 2013-04-23 | 2019-03-20 | The University Court of The University of Aberdeen | Isolation of therapeutic target specific vnar domains to icosl |
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| US20180171020A1 (en) | 2018-06-21 |
| US11001640B2 (en) | 2021-05-11 |
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| AU2015342264B2 (en) | 2021-08-12 |
| JP6734271B2 (ja) | 2020-08-05 |
| WO2016070959A1 (en) | 2016-05-12 |
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| EEER | Examination request |
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Effective date: 20220421 |
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| FZDE | Discontinued |
Effective date: 20220421 |