CA2960655C - Peptide microarrays and novel biomarkers for celiac disease - Google Patents

Peptide microarrays and novel biomarkers for celiac disease Download PDF

Info

Publication number
CA2960655C
CA2960655C CA2960655A CA2960655A CA2960655C CA 2960655 C CA2960655 C CA 2960655C CA 2960655 A CA2960655 A CA 2960655A CA 2960655 A CA2960655 A CA 2960655A CA 2960655 C CA2960655 C CA 2960655C
Authority
CA
Canada
Prior art keywords
array
polypeptide
peptide
seq
features
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2960655A
Other languages
English (en)
French (fr)
Other versions
CA2960655A1 (en
Inventor
John J. Rajasekaran
Vasanth JAYARAMAN
Kang BEI
Tianhao WANG
Karthik Krishna
Hari Krishnan KRISHNAMURTHY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vibrant Holdings LLC
Original Assignee
Vibrant Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vibrant Holdings LLC filed Critical Vibrant Holdings LLC
Publication of CA2960655A1 publication Critical patent/CA2960655A1/en
Application granted granted Critical
Publication of CA2960655C publication Critical patent/CA2960655C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/02Nutritional disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/24Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2960655A 2014-09-10 2015-09-10 Peptide microarrays and novel biomarkers for celiac disease Active CA2960655C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462048537P 2014-09-10 2014-09-10
US62/048,537 2014-09-10
PCT/US2015/049528 WO2016040703A1 (en) 2014-09-10 2015-09-10 Peptide microarrays and novel biomarkers for celiac disease

Publications (2)

Publication Number Publication Date
CA2960655A1 CA2960655A1 (en) 2016-03-17
CA2960655C true CA2960655C (en) 2024-03-19

Family

ID=55459587

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2960655A Active CA2960655C (en) 2014-09-10 2015-09-10 Peptide microarrays and novel biomarkers for celiac disease

Country Status (7)

Country Link
US (2) US10900964B2 (OSRAM)
EP (1) EP3191629A4 (OSRAM)
JP (3) JP6887945B2 (OSRAM)
AU (3) AU2015314934A1 (OSRAM)
CA (1) CA2960655C (OSRAM)
NZ (1) NZ730519A (OSRAM)
WO (1) WO2016040703A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6887945B2 (ja) 2014-09-10 2021-06-16 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー セリアック病に関するペプチドマイクロアレイおよび新規バイオマーカー
NZ742318A (en) 2015-10-29 2019-10-25 Vibrant Holdings Llc Methods, tools, and tool assemblies for biomolecular analysis using microarrays
CN109790203A (zh) * 2016-06-20 2019-05-21 健康之语公司 自身免疫疾病的诊断和治疗方法
WO2017223116A2 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
CN110073217A (zh) 2016-10-04 2019-07-30 豪夫迈·罗氏有限公司 用于鉴定合成分类器的系统和方法
US11371990B2 (en) 2016-11-11 2022-06-28 Cowper Sciences Inc. Methods for identifying candidate biomarkers
CN107176974B (zh) * 2017-06-06 2021-04-13 中国医学科学院北京协和医院 ω-5-醇溶蛋白特异的CD4+T细胞表位及其应用
WO2019136322A1 (en) * 2018-01-05 2019-07-11 Centrillion Technologies, Inc. Methods for fabricating high resolution dna array and its application in sequencing
JP7664838B2 (ja) * 2018-10-08 2025-04-18 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー セリアック病をモニタリングするためのtTG-DGPバイオマーカー
CN111926051A (zh) * 2020-07-10 2020-11-13 内蒙古燕谷坊全谷物产业发展有限责任公司 一种燕麦肽粉及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19630557C2 (de) 1996-07-18 1998-07-02 Schuppan Detlef Priv Doz Dr Dr Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Gewebe-Transglutaminase (tTG) sowie die Verwendung von tTG in Diagnose und Therapie
EP1197755A1 (en) 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
AU2002241504A1 (en) 2000-11-13 2002-06-18 Picoliter Inc. Integrated device with surface-attached molecular moieties and related machine-readable information
JP2002320341A (ja) 2001-02-14 2002-10-31 Sony Corp 充放電装置および方法、電力供給装置および方法、電力供給システムおよび方法、プログラム格納媒体、並びにプログラム
WO2003046508A2 (en) 2001-11-09 2003-06-05 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
GB0212885D0 (en) * 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
US7290169B2 (en) 2004-04-06 2007-10-30 Hewlett-Packard Development Company, L.P. Core-level processor lockstepping
CA2732108A1 (en) 2008-07-28 2010-02-04 Children's Medical Center Corporation Prominin-1 peptide fragments and uses thereof
MX346450B (es) * 2008-11-30 2017-03-17 Immusant Inc * Composiciones y métodos para el tratamiento de la enfermedad celíaca.
FR2949782B1 (fr) * 2009-09-04 2015-10-16 Isp Investments Inc Peptide activateur de la transglutaminase et composition cosmetique ou pharmaceutique le contenant.
CA3191015A1 (en) * 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
DE102013214247A1 (de) 2013-07-22 2015-01-22 Bayerische Motoren Werke Aktiengesellschaft Blindnietmutter für die Verbindung zweier Bauteile
CN103675291A (zh) * 2013-11-25 2014-03-26 南昌大学 一种基于t细胞表位筛查低乳糜泻毒性小麦品种的方法
JP6887945B2 (ja) 2014-09-10 2021-06-16 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー セリアック病に関するペプチドマイクロアレイおよび新規バイオマーカー

Also Published As

Publication number Publication date
US20210285948A1 (en) 2021-09-16
AU2015314934A1 (en) 2017-04-20
WO2016040703A1 (en) 2016-03-17
JP7256229B2 (ja) 2023-04-11
JP6887945B2 (ja) 2021-06-16
JP2017532544A (ja) 2017-11-02
JP7781813B2 (ja) 2025-12-08
US20170269077A1 (en) 2017-09-21
NZ742911A (en) 2024-02-23
NZ730519A (en) 2018-10-26
EP3191629A4 (en) 2018-07-11
JP2021144040A (ja) 2021-09-24
AU2019200921B2 (en) 2021-07-01
AU2021203987A1 (en) 2021-07-08
US10900964B2 (en) 2021-01-26
EP3191629A1 (en) 2017-07-19
CA2960655A1 (en) 2016-03-17
JP2023093494A (ja) 2023-07-04
AU2019200921A1 (en) 2019-03-07

Similar Documents

Publication Publication Date Title
AU2019200921B2 (en) Peptide microarrays and novel biomarkers for celiac disease
JP6027215B2 (ja) セリアック病の処置のための組成物および方法
PT2083856E (pt) Péptidos para a dessensibilização contra alergénios
BR122013006960A2 (pt) Peptídeo sintético que é imunologicamente reativo com um anticorpo de proteína anti-citrulinado, seu uso e seu método de identificação, bem como kit compreendendo o referido peptídeo
CN103502515B (zh) 自身免疫疾病的抗原替代物
CN101282989A (zh) 用于诊断风湿性疾病的方法
AU2003275941A1 (en) Recombinant protein variants
CA2925000A1 (en) Compositions and methods related to oat sensitivity
JP7664838B2 (ja) セリアック病をモニタリングするためのtTG-DGPバイオマーカー
LAHDEAHO et al. Activation of Celiac Disease Immune System by Specific ax-Gliadin Peptides
AU2012205288B2 (en) DNA-sequence and recombinant production of group 4 major allergens from cereals
US20170296652A1 (en) Methods and compositions involving recombinant hypoallergens

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308

EEER Examination request

Effective date: 20170308