CA2956550A1 - Bruton's tyrosine kinase inhibitor combinations and uses thereof - Google Patents
Bruton's tyrosine kinase inhibitor combinations and uses thereof Download PDFInfo
- Publication number
- CA2956550A1 CA2956550A1 CA2956550A CA2956550A CA2956550A1 CA 2956550 A1 CA2956550 A1 CA 2956550A1 CA 2956550 A CA2956550 A CA 2956550A CA 2956550 A CA2956550 A CA 2956550A CA 2956550 A1 CA2956550 A1 CA 2956550A1
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- Prior art keywords
- inhibitor
- anticancer agent
- cell
- lymphoma
- mcl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US201562196251P | 2015-07-23 | 2015-07-23 | |
| US62/196,251 | 2015-07-23 | ||
| PCT/US2015/044095 WO2016022853A1 (en) | 2014-08-08 | 2015-08-06 | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
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| EP2575818A4 (en) | 2010-06-03 | 2013-11-06 | Pharmacyclics Inc | USE OF BRUTON TYROSINE KINASE INHIBITORS (BTK) |
| JP6575950B2 (ja) | 2012-07-24 | 2019-09-18 | ファーマサイクリックス エルエルシー | Ｂｒｕｔｏｎ型チロシンキナーゼ（Ｂｔｋ）阻害剤に対する耐性を伴う変異 |
| ES2900184T3 (es) | 2014-08-11 | 2022-03-16 | Acerta Pharma Bv | Combinaciones terapéuticas de un inhibidor de BTK y un inhibidor de BCL-2 |
| WO2016071770A2 (en) * | 2014-11-05 | 2016-05-12 | Janssen Pharmaceutica Nv | Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same |
| EP3463318A4 (en) | 2016-05-27 | 2020-01-01 | TG Therapeutics Inc. | COMBINATION OF ANTI-CD20-ANTIBODIES, P13-KINASE-DELTA-SELECTIVE INHIBITOR AND BTK-INHIBITOR FOR THE TREATMENT OF PROLIFERATIVE B-CELL DISORDERS |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| EP4317422A3 (en) | 2017-04-13 | 2024-05-01 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| PE20200336A1 (es) | 2017-07-14 | 2020-02-14 | Janssen Pharmaceutica Nv | Formulaciones a largo plazo |
| WO2019070777A2 (en) * | 2017-10-04 | 2019-04-11 | University Of Maryland, Baltimore County | PIM KINASE INHIBITORS IN COMBINATION WITH AUTOPHAGIA INHIBITORS FOR THE TREATMENT OF CANCERS |
| TW202014184A (zh) * | 2018-04-30 | 2020-04-16 | 瑞典商阿斯特捷利康公司 | 用於治療癌症之組合 |
| MX2020011527A (es) | 2018-05-03 | 2021-02-26 | Juno Therapeutics Inc | Terapia de combinación de una terapia de células t-receptor de antígeno quimérico (car) y un inhibidor de cinasa. |
| CN111053777A (zh) * | 2018-10-16 | 2020-04-24 | 正大天晴药业集团股份有限公司 | 伊布替尼的药物组合物及其应用 |
| SG11202103317XA (en) | 2018-10-17 | 2021-05-28 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2020205643C1 (en) * | 2019-01-09 | 2025-07-31 | Celgene Corporation | Antiproliferative compounds and second active agents for use in treating multiple myeloma |
| US12269813B2 (en) | 2019-02-22 | 2025-04-08 | Janssen Pharmaceutica Nv | Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide monohydrate |
| JP7554768B2 (ja) | 2019-04-11 | 2024-09-20 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤としての尿素誘導体 |
| EP3871665B1 (en) | 2020-02-28 | 2025-12-24 | Martin-Luther-Universität Halle-Wittenberg | Inhibitors of rna-binding proteins as anti-cancer drugs |
| US20240139205A1 (en) * | 2020-03-05 | 2024-05-02 | Universite De Lausanne | Modulators of aralar for treating neurological disorders |
| PE20231296A1 (es) * | 2020-07-09 | 2023-08-22 | Janssen Pharmaceutica Nv | Formulaciones a largo plazo |
| EP4199908A1 (en) * | 2020-08-21 | 2023-06-28 | JANSSEN Pharmaceutica NV | Amorphous form of a malt1 inhibitor and formulations thereof |
| EP3967307A1 (en) * | 2020-09-15 | 2022-03-16 | Instytut Hematologii I Transfuzologii | Use of pim kinase inhibitors to augment the efficacy of anti-cd20 antibody-based therapies in hematologic malignancies and non-malignant conditions |
| CN114469949A (zh) * | 2020-10-27 | 2022-05-13 | 正大天晴药业集团股份有限公司 | 用于治疗弥漫大b细胞淋巴瘤的喹啉衍生物 |
| BR112023017648A2 (pt) * | 2021-03-03 | 2023-11-14 | Janssen Pharmaceutica Nv | Terapia de combinação com o uso de um inibidor de malt1 e um inibidor de btk |
| US20250302954A1 (en) | 2022-05-11 | 2025-10-02 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| WO2025002340A1 (zh) * | 2023-06-29 | 2025-01-02 | 上海翰森生物医药科技有限公司 | 三并环类抑制剂与抗癌剂在制备抗肿瘤药物中的联合应用 |
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| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| US7832117B2 (en) * | 2006-07-17 | 2010-11-16 | Nike, Inc. | Article of footwear including full length composite plate |
| NZ601278A (en) | 2006-09-22 | 2013-09-27 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| WO2009021137A2 (en) | 2007-08-07 | 2009-02-12 | Purdue Research Foundation | Kinase inhibitors and uses thereof |
| EP2575818A4 (en) | 2010-06-03 | 2013-11-06 | Pharmacyclics Inc | USE OF BRUTON TYROSINE KINASE INHIBITORS (BTK) |
| WO2013059738A2 (en) | 2011-10-19 | 2013-04-25 | Pharmacyclics, Inc. | Use of inhibitors of bruton's tyrosine kinase (btk) |
| CA2875986C (en) * | 2012-06-04 | 2020-06-09 | Pharmacyclics, Inc. | Crystalline forms of a bruton's tyrosine kinase inhibitor |
| BR112014032346A2 (pt) | 2012-06-26 | 2017-06-27 | Del Mar Pharmaceuticals | métodos para tratamento de malignidades resistentes ao inibidor de tirosina-quinase em pacientes com polimorfismos genéticos ou desregulações de ahi1 mutações empregando dianidrogalactitol, diacetildianidrogalactitol, dibromodulcitol, ou análogos ou derivados destes |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
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| US20160038495A1 (en) | 2016-02-11 |
| US20180071295A1 (en) | 2018-03-15 |
| MX2017001656A (es) | 2017-07-24 |
| TW201609107A (zh) | 2016-03-16 |
| WO2016022853A1 (en) | 2016-02-11 |
| EP3177366A4 (en) | 2018-04-04 |
| EP3177366A1 (en) | 2017-06-14 |
| TWI586354B (zh) | 2017-06-11 |
| CN106714909A (zh) | 2017-05-24 |
| AU2015300966A1 (en) | 2017-02-16 |
| US9730938B2 (en) | 2017-08-15 |
| BR112017002232A2 (pt) | 2018-07-24 |
| JP2017523207A (ja) | 2017-08-17 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20200831 |