CA2956385A1 - Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule - Google Patents
Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule Download PDFInfo
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- A61K40/42—Cancer antigens
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| WO2018197949A1 (en) | 2017-04-27 | 2018-11-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| WO2018204352A1 (en) | 2017-05-01 | 2018-11-08 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against alpha-synuclein fibrils |
| US20200283485A1 (en) | 2017-10-20 | 2020-09-10 | Institut Curie | Hook fusion protein for regulating the cellular trafficking of a target protein |
| US20200331975A1 (en) | 2017-10-20 | 2020-10-22 | Institut Curie | Dap10/12 based cars adapted for rush |
| CA3080109A1 (en) | 2017-11-03 | 2019-05-09 | Sorrento Therapeutics, Inc. | Cd38-directed chimeric antigen receptor constructs |
| EP3740199B1 (en) | 2018-01-17 | 2024-08-14 | Ixaka France | Polymer-encapsulated viral vectors for genetic therapy |
| EP3549597A1 (en) * | 2018-04-06 | 2019-10-09 | Heinrich-Heine-Universität Düsseldorf | Synthetic signalling constructs and its use |
| WO2019199689A1 (en) * | 2018-04-09 | 2019-10-17 | The Trustees Of The University Of Pennsylvania | Methods and compositions comprising a viral vector for expression of a transgene and an effector |
| US12215337B2 (en) | 2018-04-12 | 2025-02-04 | Umoja Biopharma, Inc. | Viral vectors and packaging cell lines |
| US12319745B2 (en) | 2019-07-16 | 2025-06-03 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antibodies having specificity for CD38 and uses thereof |
| AU2020345943A1 (en) | 2019-09-10 | 2022-03-31 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
| GB201914611D0 (en) * | 2019-10-09 | 2019-11-20 | Autolus Ltd | Engineered immune cell |
| US20230085724A1 (en) | 2020-03-05 | 2023-03-23 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
| AU2021337534A1 (en) * | 2020-09-01 | 2023-03-16 | The Trustees Of The University Of Pennsylvania | Improved generation of lentiviral vectors for T cell transduction using cocal envelope |
| JP2023554542A (ja) | 2020-11-13 | 2023-12-27 | ホーニング バイオサイエンシズ | 目的の分泌性タンパク質または細胞膜固定タンパク質の細胞内輸送を制御するための手段および方法 |
| IT202100011576A1 (it) * | 2021-05-06 | 2022-11-06 | Univ Degli Studi Padova | Nuova sequenza promotore per terapia genica |
| KR20240124919A (ko) | 2021-11-15 | 2024-08-19 | 떼라벡띠스 | 인유두종 바이러스 항원의 발현을 위한 렌티바이러스 벡터 및 이의 hpv 유발 암 치료에 대한 구현 |
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| EP4624494A1 (en) | 2024-03-29 | 2025-10-01 | Institut Curie | Her2 single domain antibody and uses thereof |
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| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| SG11201404769UA (en) * | 2012-02-22 | 2014-11-27 | Univ Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
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| CA2933707A1 (en) * | 2013-12-20 | 2015-06-25 | Fred Hutchinson Cancer Research Center | Tagged chimeric effector molecules and receptors thereof |
| GB2592821B (en) * | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
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| HK1248720A1 (zh) | 2018-10-19 |
| US20170166623A1 (en) | 2017-06-15 |
| CN113846062B (zh) | 2025-02-21 |
| EP3511413B1 (en) | 2022-09-07 |
| JP7341110B2 (ja) | 2023-09-08 |
| JP6940406B2 (ja) | 2021-09-29 |
| US10752668B2 (en) | 2020-08-25 |
| WO2016012623A1 (en) | 2016-01-28 |
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