CA2947012C - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds Download PDF

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Publication number
CA2947012C
CA2947012C CA2947012A CA2947012A CA2947012C CA 2947012 C CA2947012 C CA 2947012C CA 2947012 A CA2947012 A CA 2947012A CA 2947012 A CA2947012 A CA 2947012A CA 2947012 C CA2947012 C CA 2947012C
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CA
Canada
Prior art keywords
formula
compound
range
amount
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2947012A
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English (en)
French (fr)
Other versions
CA2947012A1 (en
Inventor
Matteo CONZA
Vit Lellek
Hartmut Zinser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Priority to CA3208298A priority Critical patent/CA3208298A1/en
Publication of CA2947012A1 publication Critical patent/CA2947012A1/en
Application granted granted Critical
Publication of CA2947012C publication Critical patent/CA2947012C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2947012A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Active CA2947012C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3208298A CA3208298A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988,523 2014-05-05
US14/689,712 2015-04-17
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027912 WO2015171354A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3208298A Division CA3208298A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (2)

Publication Number Publication Date
CA2947012A1 CA2947012A1 (en) 2015-11-12
CA2947012C true CA2947012C (en) 2023-09-26

Family

ID=54354748

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2947012A Active CA2947012C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds
CA3208298A Pending CA3208298A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3208298A Pending CA3208298A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (9)

Country Link
US (1) US9701688B2 (en:Method)
EP (1) EP3140308B8 (en:Method)
JP (2) JP6792745B2 (en:Method)
CN (1) CN107001381A (en:Method)
AU (3) AU2015256416B2 (en:Method)
CA (2) CA2947012C (en:Method)
DK (1) DK3140308T3 (en:Method)
ES (1) ES2946177T3 (en:Method)
WO (1) WO2015171354A2 (en:Method)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
WO2008064351A2 (en) 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs
EP2152715B1 (en) * 2007-05-04 2010-12-29 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
CA2720034A1 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
WO2010039209A2 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
CA2738250C (en) 2008-09-30 2018-08-14 Mallinckrodt Inc. Processes for increasing the yield of the hydrolysis of the 3-o-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
WO2010039210A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
PL2342207T3 (pl) 2008-09-30 2016-05-31 SpecGx LLC Sposoby alkilowania norbuprenorfiny ze zmniejszonym powstawaniem zanieczyszczeń
WO2010096416A1 (en) 2009-02-17 2010-08-26 Mallinckrodt Inc. Process for the reductive alkylation of normorphinans
NZ595591A (en) 2009-04-24 2013-11-29 Univ Brock Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
TWI471289B (zh) * 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
SMT201700177T1 (it) * 2010-11-05 2017-05-08 H Lundbeck As Procedimento per la fabbricazione di naltrexone
JP6046119B2 (ja) 2011-05-02 2016-12-14 ブロック ユニバーシティ 脱水環化試薬を使用するｎ−オキシドのｎ−脱メチル化によるモルヒネ類似体の調製における方法および中間体
HUE040284T2 (hu) 2011-10-03 2019-02-28 Johnson Matthey Plc Eljárás buprenorfin elõállítására
AU2013214667A1 (en) 2012-02-03 2014-09-25 Brock University Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
US20140155608A1 (en) * 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone

Also Published As

Publication number Publication date
AU2018203948B2 (en) 2019-12-19
CA2947012A1 (en) 2015-11-12
ES2946177T3 (es) 2023-07-13
EP3140308B1 (en) 2023-05-24
CN107001381A (zh) 2017-08-01
US20150315205A1 (en) 2015-11-05
CA3208298A1 (en) 2015-11-12
JP6792745B2 (ja) 2020-12-02
WO2015171354A2 (en) 2015-11-12
AU2015256416B2 (en) 2018-03-08
AU2018203948A1 (en) 2018-06-21
DK3140308T3 (da) 2023-06-19
WO2015171354A3 (en) 2016-03-17
AU2020201990A1 (en) 2020-04-09
EP3140308B8 (en) 2023-06-28
EP3140308A2 (en) 2017-03-15
JP2017514846A (ja) 2017-06-08
US9701688B2 (en) 2017-07-11
AU2015256416A1 (en) 2016-11-24
JP2020073598A (ja) 2020-05-14

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