CA2942236C - Dosage form of siponimod - Google Patents
Dosage form of siponimod Download PDFInfo
- Publication number
- CA2942236C CA2942236C CA2942236A CA2942236A CA2942236C CA 2942236 C CA2942236 C CA 2942236C CA 2942236 A CA2942236 A CA 2942236A CA 2942236 A CA2942236 A CA 2942236A CA 2942236 C CA2942236 C CA 2942236C
- Authority
- CA
- Canada
- Prior art keywords
- siponimod
- dosage form
- amount
- protective agent
- moisture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KIHYPELVXPAIDH-HNSNBQBZSA-N 1-[[4-[(e)-n-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-c-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid Chemical compound CCC1=CC(C(\C)=N\OCC=2C=C(C(C3CCCCC3)=CC=2)C(F)(F)F)=CC=C1CN1CC(C(O)=O)C1 KIHYPELVXPAIDH-HNSNBQBZSA-N 0.000 title claims abstract description 161
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- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Communicable Diseases (AREA)
- Oncology (AREA)
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Applications Claiming Priority (3)
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| US201461977806P | 2014-04-10 | 2014-04-10 | |
| US61/977,806 | 2014-04-10 | ||
| PCT/IB2015/052552 WO2015155711A1 (en) | 2014-04-10 | 2015-04-08 | Immunosuppressant formulation |
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| CA2942236A1 CA2942236A1 (en) | 2015-10-15 |
| CA2942236C true CA2942236C (en) | 2023-08-29 |
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| CA2942236A Active CA2942236C (en) | 2014-04-10 | 2015-04-08 | Dosage form of siponimod |
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| KR101951966B1 (ko) | 2011-01-07 | 2019-02-25 | 노파르티스 아게 | 면역억제제 제제 |
| JP6679495B2 (ja) * | 2014-04-10 | 2020-04-15 | ノバルティス アーゲー | 免疫抑制製剤 |
| US11434200B2 (en) | 2017-03-09 | 2022-09-06 | Novartis Ag | Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof |
| US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| WO2019064185A1 (en) | 2017-09-27 | 2019-04-04 | Novartis Ag | PARENTERAL FORMULATION COMPRISING SITOMOD |
| CA3074416A1 (en) | 2017-09-29 | 2019-04-04 | Novartis Ag | Dosing regimen of siponimod |
| WO2019064212A1 (en) | 2017-09-29 | 2019-04-04 | Novartis Ag | DOSAGE DIAGRAM OF SIPONIMOD |
| WO2019144094A1 (en) * | 2018-01-22 | 2019-07-25 | Teva Pharmaceuticals International Gmbh | Crystalline siponimod fumaric acid and polymorphs thereof |
| CN109908095A (zh) * | 2019-04-08 | 2019-06-21 | 肇庆学院 | 一种西尼莫德片剂及制备方法 |
| WO2021214717A1 (en) | 2020-04-23 | 2021-10-28 | Novartis Ag | Dosing regimen for the use of siponimod for the treatment of acute respiratory distress syndrome |
| CN113633632A (zh) * | 2021-09-09 | 2021-11-12 | 暨南大学附属第一医院（广州华侨医院） | siponimod在制备抗肿瘤转移药物中的应用 |
| WO2024126409A1 (en) | 2022-12-12 | 2024-06-20 | Synthon B.V. | Pharmaceutical composition of siponimod |
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| HUE027696T2 (en) * | 2007-10-12 | 2016-10-28 | Novartis Ag | Preparations containing sphingosine-1-phosphate (S1P) receptor modulators |
| GB2473399B (en) | 2008-07-16 | 2012-06-27 | Nec Corp | Method for reporting information about result of Iu-UP protocol negotiation protocol conversion method,communication network system |
| US20120115840A1 (en) | 2008-12-18 | 2012-05-10 | Lech Ciszewski | Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid |
| BRPI0922457A2 (pt) | 2008-12-18 | 2015-12-15 | Novartis Ag | forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico" |
| CA2981830A1 (en) * | 2008-12-22 | 2010-07-01 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
| CN101480374A (zh) * | 2009-01-20 | 2009-07-15 | 苏州中化药品工业有限公司 | 一种稳定的固体药物组合物 |
| KR101951966B1 (ko) * | 2011-01-07 | 2019-02-25 | 노파르티스 아게 | 면역억제제 제제 |
| WO2012095853A1 (en) * | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Modified release formulations comprising sip receptor modulators |
| JP6679495B2 (ja) * | 2014-04-10 | 2020-04-15 | ノバルティス アーゲー | 免疫抑制製剤 |
-
2015
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- 2015-04-08 ES ES15735733T patent/ES2865451T3/es active Active
- 2015-04-08 SI SI201531566T patent/SI3129006T1/sl unknown
- 2015-04-08 SG SG11201607354PA patent/SG11201607354PA/en unknown
- 2015-04-08 EP EP15735733.6A patent/EP3129006B1/en active Active
- 2015-04-08 DK DK15735733.6T patent/DK3129006T3/da active
- 2015-04-08 HU HUE15735733A patent/HUE054245T2/hu unknown
- 2015-04-08 CA CA2942236A patent/CA2942236C/en active Active
- 2015-04-08 PE PE2016001740A patent/PE20161385A1/es not_active Application Discontinuation
- 2015-04-08 PL PL15735733T patent/PL3129006T3/pl unknown
- 2015-04-08 WO PCT/IB2015/052552 patent/WO2015155711A1/en not_active Ceased
- 2015-04-08 US US15/300,968 patent/US20170027906A1/en not_active Abandoned
- 2015-04-08 PT PT157357336T patent/PT3129006T/pt unknown
- 2015-04-08 CN CN201580018811.7A patent/CN106163502B/zh active Active
- 2015-04-08 MX MX2016013236A patent/MX2016013236A/es unknown
- 2015-04-08 AU AU2015246038A patent/AU2015246038C1/en active Active
- 2015-04-09 TW TW104111464A patent/TW201622707A/zh unknown
- 2015-04-10 AR ARP150101084A patent/AR100002A1/es unknown
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2016
- 2016-09-01 IL IL247599A patent/IL247599B/en active IP Right Grant
- 2016-09-20 PH PH12016501841A patent/PH12016501841A1/en unknown
- 2016-10-07 CL CL2016002560A patent/CL2016002560A1/es unknown
-
2018
- 2018-03-20 US US15/926,699 patent/US20180207128A1/en not_active Abandoned
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2019
- 2019-03-21 US US16/360,696 patent/US20190328705A1/en not_active Abandoned
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2020
- 2020-01-24 JP JP2020009871A patent/JP2020097591A/ja not_active Withdrawn
-
2021
- 2021-02-04 US US17/167,635 patent/US20210161860A1/en not_active Abandoned
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2024
- 2024-03-14 US US18/605,259 patent/US20250073203A1/en active Pending
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