CA2936548C - The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders - Google Patents

The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders Download PDF

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Publication number
CA2936548C
CA2936548C CA2936548A CA2936548A CA2936548C CA 2936548 C CA2936548 C CA 2936548C CA 2936548 A CA2936548 A CA 2936548A CA 2936548 A CA2936548 A CA 2936548A CA 2936548 C CA2936548 C CA 2936548C
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CA
Canada
Prior art keywords
mice
pharmaceutical composition
gtb
glyceryl
eae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2936548A
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English (en)
French (fr)
Other versions
CA2936548A1 (en
Inventor
Kalipada PAHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rush University Medical Center
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Rush University Medical Center
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Filing date
Publication date
Application filed by Rush University Medical Center filed Critical Rush University Medical Center
Publication of CA2936548A1 publication Critical patent/CA2936548A1/en
Application granted granted Critical
Publication of CA2936548C publication Critical patent/CA2936548C/en
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2936548A 2014-01-17 2015-01-16 The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders Active CA2936548C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461928622P 2014-01-17 2014-01-17
US61/928,622 2014-01-17
PCT/US2015/011798 WO2015109215A1 (en) 2014-01-17 2015-01-16 The use of a benzoate containing composition in urea cycle disorders and neurodegenerativre disordrs

Publications (2)

Publication Number Publication Date
CA2936548A1 CA2936548A1 (en) 2015-07-23
CA2936548C true CA2936548C (en) 2022-08-30

Family

ID=53543490

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2936548A Active CA2936548C (en) 2014-01-17 2015-01-16 The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders

Country Status (16)

Country Link
US (1) US9968582B2 (cg-RX-API-DMAC7.html)
EP (1) EP3094616B1 (cg-RX-API-DMAC7.html)
JP (2) JP6836905B2 (cg-RX-API-DMAC7.html)
CA (1) CA2936548C (cg-RX-API-DMAC7.html)
CY (1) CY1124115T1 (cg-RX-API-DMAC7.html)
DK (1) DK3094616T3 (cg-RX-API-DMAC7.html)
ES (1) ES2853974T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20210361T1 (cg-RX-API-DMAC7.html)
HU (1) HUE053671T2 (cg-RX-API-DMAC7.html)
LT (1) LT3094616T (cg-RX-API-DMAC7.html)
PL (1) PL3094616T3 (cg-RX-API-DMAC7.html)
PT (1) PT3094616T (cg-RX-API-DMAC7.html)
RS (1) RS61611B1 (cg-RX-API-DMAC7.html)
SI (1) SI3094616T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202100074T1 (cg-RX-API-DMAC7.html)
WO (1) WO2015109215A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018345244A1 (en) 2017-10-06 2020-04-02 Rush University Medical Center The use of a benzoate containing composition to treat glycine encephalopathy
KR20200088861A (ko) 2017-11-22 2020-07-23 치에-신 린 우울증의 예방 또는 치료용 벤조익산 또는 이의 염 및 유도체
US12478598B2 (en) 2019-02-25 2025-11-25 Rush University Medical Center Compositions including cinnamic acid and methods of use thereof
WO2021011500A2 (en) * 2019-07-16 2021-01-21 Rush University Medical Center Use of a benzoate containing composition to treat neurodegenerative disorders
CN116390761A (zh) * 2020-10-28 2023-07-04 拉什大学医学中心 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用
CA3205005A1 (en) * 2020-12-16 2022-06-23 Rush University Medical Center Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders
EP4447952A4 (en) * 2021-12-16 2025-11-19 Us Gov Veterans Affairs Benzoic acid salts for the treatment of injuries and disorders of the nervous system

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284647A (en) 1980-03-31 1981-08-18 The Johns Hopkins University Process for waste nitrogen removal
US20080171792A1 (en) * 2006-12-28 2008-07-17 Jobdevairakkam Christopher New Use of highly concentrated formulations of 4-phenylbutyrate for treatment of certain disorders

Also Published As

Publication number Publication date
ES2853974T3 (es) 2021-09-20
LT3094616T (lt) 2021-04-12
EP3094616B1 (en) 2020-12-23
JP2017505811A (ja) 2017-02-23
SMT202100074T1 (it) 2021-05-07
RS61611B1 (sr) 2021-04-29
DK3094616T3 (da) 2021-02-15
CA2936548A1 (en) 2015-07-23
EP3094616A1 (en) 2016-11-23
CY1124115T1 (el) 2022-05-27
US20160331714A1 (en) 2016-11-17
WO2015109215A1 (en) 2015-07-23
PT3094616T (pt) 2021-03-03
HUE053671T2 (hu) 2021-07-28
EP3094616A4 (en) 2017-08-23
JP6836905B2 (ja) 2021-03-03
US9968582B2 (en) 2018-05-15
HRP20210361T1 (hr) 2021-04-16
PL3094616T3 (pl) 2021-05-31
JP2020037558A (ja) 2020-03-12
SI3094616T1 (sl) 2021-07-30

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