CA2933472A1 - Compositions, methods of administration and uses for trivalent dengue virus formulations - Google Patents
Compositions, methods of administration and uses for trivalent dengue virus formulations Download PDFInfo
- Publication number
- CA2933472A1 CA2933472A1 CA2933472A CA2933472A CA2933472A1 CA 2933472 A1 CA2933472 A1 CA 2933472A1 CA 2933472 A CA2933472 A CA 2933472A CA 2933472 A CA2933472 A CA 2933472A CA 2933472 A1 CA2933472 A1 CA 2933472A1
- Authority
- CA
- Canada
- Prior art keywords
- dengue
- virus
- dengue virus
- vaccine
- den
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 224
- 241000725619 Dengue virus Species 0.000 title claims abstract description 137
- 238000000034 method Methods 0.000 title claims abstract description 72
- 238000009472 formulation Methods 0.000 title description 60
- 229960005486 vaccine Drugs 0.000 claims abstract description 131
- 229940023605 dengue virus vaccine Drugs 0.000 claims abstract description 45
- 206010012310 Dengue fever Diseases 0.000 claims description 162
- 208000025729 dengue disease Diseases 0.000 claims description 157
- 208000001490 Dengue Diseases 0.000 claims description 153
- 241000700605 Viruses Species 0.000 claims description 103
- 230000002238 attenuated effect Effects 0.000 claims description 66
- 101710172711 Structural protein Proteins 0.000 claims description 44
- 241000710829 Dengue virus group Species 0.000 claims description 24
- 238000002255 vaccination Methods 0.000 claims description 22
- 230000003472 neutralizing effect Effects 0.000 claims description 18
- 238000007920 subcutaneous administration Methods 0.000 claims description 17
- 230000028993 immune response Effects 0.000 claims description 15
- 241000710815 Dengue virus 2 Species 0.000 claims description 13
- 230000002163 immunogen Effects 0.000 claims description 12
- 238000007918 intramuscular administration Methods 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 229940031418 trivalent vaccine Drugs 0.000 claims description 6
- 229940031346 monovalent vaccine Drugs 0.000 claims description 4
- 108010087302 Viral Structural Proteins Proteins 0.000 claims description 3
- 230000006698 induction Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 1
- 230000004044 response Effects 0.000 abstract description 9
- 230000035772 mutation Effects 0.000 description 40
- 108090000623 proteins and genes Proteins 0.000 description 39
- 241000710831 Flavivirus Species 0.000 description 21
- 235000001014 amino acid Nutrition 0.000 description 20
- 208000015181 infectious disease Diseases 0.000 description 18
- 102000004169 proteins and genes Human genes 0.000 description 15
- 101710204837 Envelope small membrane protein Proteins 0.000 description 14
- 101710145006 Lysis protein Proteins 0.000 description 14
- 108091092724 Noncoding DNA Proteins 0.000 description 14
- 235000018102 proteins Nutrition 0.000 description 14
- 210000000234 capsid Anatomy 0.000 description 13
- 208000009714 Severe Dengue Diseases 0.000 description 12
- 125000003275 alpha amino acid group Chemical group 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 11
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 101800001020 Non-structural protein 4A Proteins 0.000 description 10
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 230000005847 immunogenicity Effects 0.000 description 10
- 108020004707 nucleic acids Proteins 0.000 description 10
- 102000039446 nucleic acids Human genes 0.000 description 10
- 101800001030 Non-structural protein 2A Proteins 0.000 description 9
- 230000010076 replication Effects 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 8
- 230000003612 virological effect Effects 0.000 description 8
- 241000282412 Homo Species 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 239000002299 complementary DNA Substances 0.000 description 7
- 239000012634 fragment Substances 0.000 description 7
- 230000003053 immunization Effects 0.000 description 7
- 238000002649 immunization Methods 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 229940125575 vaccine candidate Drugs 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 201000002950 dengue hemorrhagic fever Diseases 0.000 description 6
- 201000009892 dengue shock syndrome Diseases 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 6
- 241000255925 Diptera Species 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000002458 infectious effect Effects 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
- 101710144111 Non-structural protein 3 Proteins 0.000 description 4
- 108010076039 Polyproteins Proteins 0.000 description 4
- 238000010240 RT-PCR analysis Methods 0.000 description 4
- 206010058874 Viraemia Diseases 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 101710117545 C protein Proteins 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 3
- 101710128560 Initiator protein NS1 Proteins 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- -1 NS2B Proteins 0.000 description 3
- 101710144127 Non-structural protein 1 Proteins 0.000 description 3
- 101800001019 Non-structural protein 4B Proteins 0.000 description 3
- 208000003152 Yellow Fever Diseases 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000005875 antibody response Effects 0.000 description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- 241000256118 Aedes aegypti Species 0.000 description 2
- 102100029226 Cancer-related nucleoside-triphosphatase Human genes 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 206010014596 Encephalitis Japanese B Diseases 0.000 description 2
- 241000710781 Flaviviridae Species 0.000 description 2
- 201000005807 Japanese encephalitis Diseases 0.000 description 2
- 241000710842 Japanese encephalitis virus Species 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 101710144121 Non-structural protein 5 Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 108010075285 Nucleoside-Triphosphatase Proteins 0.000 description 2
- 102000004409 RNA Helicases Human genes 0.000 description 2
- 108090000944 RNA Helicases Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 230000024932 T cell mediated immunity Effects 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 108091034135 Vault RNA Proteins 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 230000001775 anti-pathogenic effect Effects 0.000 description 2
- 229940031567 attenuated vaccine Drugs 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000028996 humoral immune response Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940031351 tetravalent vaccine Drugs 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 229940124856 vaccine component Drugs 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 229960004854 viral vaccine Drugs 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 108091093088 Amplicon Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- 201000009182 Chikungunya Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000191823 Cynomys Species 0.000 description 1
- DSTWKJOBKSMVCV-UWVGGRQHSA-N Cys-Tyr Chemical compound SC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 DSTWKJOBKSMVCV-UWVGGRQHSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 101710158312 DNA-binding protein HU-beta Proteins 0.000 description 1
- 241000710872 Dengue virus 3 Species 0.000 description 1
- 241000712471 Dhori virus Species 0.000 description 1
- 101150013191 E gene Proteins 0.000 description 1
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000282339 Mustela Species 0.000 description 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 241000208465 Proteaceae Species 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 108010066717 Q beta Replicase Proteins 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000710772 Yellow fever virus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 108010069495 cysteinyltyrosine Proteins 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000004077 genetic alteration Effects 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000002134 immunopathologic effect Effects 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- KJLLKLRVCJAFRY-UHFFFAOYSA-N mebutizide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)NC(C(C)C(C)CC)NC2=C1 KJLLKLRVCJAFRY-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- 238000001668 nucleic acid synthesis Methods 0.000 description 1
- 229940127241 oral polio vaccine Drugs 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940021993 prophylactic vaccine Drugs 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000037432 silent mutation Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737679P | 2012-12-14 | 2012-12-14 | |
| US61/737,679 | 2012-12-14 | ||
| PCT/US2013/073757 WO2014093182A1 (en) | 2012-12-14 | 2013-12-07 | Compositions, methods of administration and uses for trivalent dengue virus formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2933472A1 true CA2933472A1 (en) | 2014-06-19 |
Family
ID=50934851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2933472A Abandoned CA2933472A1 (en) | 2012-12-14 | 2013-12-07 | Compositions, methods of administration and uses for trivalent dengue virus formulations |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9878031B2 (enExample) |
| EP (1) | EP2931310A4 (enExample) |
| JP (1) | JP2016504315A (enExample) |
| CA (1) | CA2933472A1 (enExample) |
| WO (1) | WO2014093182A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113637086B (zh) * | 2013-03-15 | 2024-10-11 | 武田疫苗股份有限公司 | 用于疫苗中的登革热病毒嵌合式构建物的组合物及方法 |
| WO2016130786A2 (en) * | 2015-02-15 | 2016-08-18 | Integral Molecular, Inc. | Flaviviridae proteins and virions and methods of use thereof |
| SG10201913383RA (en) | 2016-04-13 | 2020-03-30 | Takeda Vaccines Inc | Compositions and methods of vaccination against dengue virus in children and young adults |
| ES2908304T3 (es) * | 2018-09-05 | 2022-04-28 | Takeda Vaccines Inc | Dosis unitaria de vacuna contra el dengue y administración de la misma |
| US11464815B2 (en) | 2018-09-05 | 2022-10-11 | Takeda Vaccines, Inc. | Dengue vaccine unit dose and administration thereof |
| US11426461B2 (en) | 2018-09-05 | 2022-08-30 | Takeda Vaccines, Inc. | Methods for preventing dengue and hepatitis A |
| EP4013451A1 (en) * | 2019-08-16 | 2022-06-22 | Takeda Vaccines, Inc. | Methods for preventing dengue and hepatitis a |
| WO2024108087A1 (en) * | 2022-11-18 | 2024-05-23 | Takeda Vaccines, Inc. | A method for determining the proportion of a live, attenuated flavivirus having a nucleotide sequence comprising at least one attenuation locus in a formulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2941182A1 (en) | 2000-02-16 | 2001-08-23 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Avirulent, immunogenic flavivirus chimeras |
| US20040120964A1 (en) | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
| US20040259224A1 (en) | 2002-05-31 | 2004-12-23 | Farshad Guirakhoo | Tetravalent Dengue vaccines |
| US8029802B2 (en) | 2004-10-20 | 2011-10-04 | Sanofi Pasteur Biologics Co. | Vaccines against Japanese encephalitis virus and West Nile virus |
| ATE475706T1 (de) | 2005-06-17 | 2010-08-15 | Sanofi Pasteur | Abgeschwächter dengue-serotyp-2-stamm |
| BRPI0613328A2 (pt) * | 2005-06-17 | 2011-01-04 | Sanofi Pasteur | cepa do vìrus da dengue-1 vivo atenuado, composição imunogênica, composição de vacina, ácido nucléico isolado, poliproteìna isolada e fragmento de poliproteìna |
| JP5227172B2 (ja) | 2005-08-10 | 2013-07-03 | サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー | デングウイルス感染に対するワクチン接種 |
| BR122020023372B1 (pt) | 2006-08-15 | 2021-11-30 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Vírus da dengue do tipo 3 (den3) atenuado e composição imunogênica |
| FR2906724B1 (fr) | 2006-10-04 | 2009-03-20 | Sanofi Pasteur Sa | Methode d'immunisation contre les 4 serotypes de la dengue. |
| US20100316670A1 (en) | 2007-06-14 | 2010-12-16 | Blaney Joseph E | Chimeric sle/dengue type 4 antigenic viruses |
| WO2010085358A2 (en) | 2009-01-23 | 2010-07-29 | The Board Of Regents Of The University Of Texas System | Flaviviruses expressing the prm, e, and ns1 proteins of other flaviviruses and uses thereof |
| US8968996B2 (en) * | 2009-06-01 | 2015-03-03 | Takeda Vaccines, Inc. | Compositions and methods for rapid immunization against dengue virus |
| NZ597000A (en) * | 2009-06-01 | 2014-07-25 | Takeda Vaccines Inc | Compositions and methods for administration of vaccines against dengue virus |
| WO2013188315A1 (en) * | 2012-06-10 | 2013-12-19 | Inviragen, Inc. | Compositions and methods for administration of vaccines against dengue virus |
| WO2012065105A2 (en) | 2010-11-12 | 2012-05-18 | Thomas Monath | Chimeric flavivirus vaccines |
-
2013
- 2013-12-07 WO PCT/US2013/073757 patent/WO2014093182A1/en not_active Ceased
- 2013-12-07 CA CA2933472A patent/CA2933472A1/en not_active Abandoned
- 2013-12-07 US US14/652,066 patent/US9878031B2/en not_active Expired - Fee Related
- 2013-12-07 EP EP13863155.1A patent/EP2931310A4/en not_active Withdrawn
- 2013-12-07 JP JP2015547441A patent/JP2016504315A/ja active Pending
-
2017
- 2017-12-15 US US15/844,030 patent/US20180228887A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180228887A1 (en) | 2018-08-16 |
| US9878031B2 (en) | 2018-01-30 |
| EP2931310A1 (en) | 2015-10-21 |
| EP2931310A4 (en) | 2016-05-25 |
| US20150335727A1 (en) | 2015-11-26 |
| WO2014093182A1 (en) | 2014-06-19 |
| JP2016504315A (ja) | 2016-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Osorio et al. | Development of DENVax: a chimeric dengue-2 PDK-53-based tetravalent vaccine for protection against dengue fever | |
| US9878031B2 (en) | Compositions, methods of administration and uses for trivalent dengue virus formulations | |
| US10898565B2 (en) | Compositions, methods and uses for dengue virus serotype-4 constructs | |
| JP5538729B2 (ja) | 偽感染性フラビウイルスおよびそれらの使用 | |
| US9713638B2 (en) | Compositions and methods for rapid immunization against dengue virus | |
| Lai et al. | Chimeric flaviviruses: novel vaccines against dengue fever, tick-borne encephalitis, and Japanese encephalitis | |
| US8029802B2 (en) | Vaccines against Japanese encephalitis virus and West Nile virus | |
| WO2013188315A1 (en) | Compositions and methods for administration of vaccines against dengue virus | |
| JP2007525226A (ja) | フラビウイルスワクチン | |
| RU2465326C2 (ru) | Рекомбинантные флавивирусные вакцины | |
| Pugachev et al. | Chimeric vaccines against Japanese encephalitis, dengue, and West Nile | |
| CN101084010B (zh) | 抗日本脑炎病毒及西尼罗病毒的疫苗 | |
| Subedi et al. | Development of a dengue vaccine in humans: So near, yet so far | |
| AU2019203166A1 (en) | Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus | |
| HK1106723B (en) | Vaccines against japanese encephalitis virus and west nile virus | |
| HK1120431A (en) | Recombinant flavivirus vaccines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |
Effective date: 20191209 |