CA2931064C - Withanolides useful for the treatment of neurodegenerative diseases - Google Patents

Withanolides useful for the treatment of neurodegenerative diseases Download PDF

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Publication number
CA2931064C
CA2931064C CA2931064A CA2931064A CA2931064C CA 2931064 C CA2931064 C CA 2931064C CA 2931064 A CA2931064 A CA 2931064A CA 2931064 A CA2931064 A CA 2931064A CA 2931064 C CA2931064 C CA 2931064C
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CA
Canada
Prior art keywords
compound
patient
preventing
treating
need
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2931064A
Other languages
English (en)
French (fr)
Other versions
CA2931064A1 (en
Inventor
Agnes H. Chan
Jean-Pierre Julien
Anthony A. Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Laval
Arna Therapeutics Inc
Original Assignee
Universite Laval
Imstar Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Laval, Imstar Therapeutics Inc filed Critical Universite Laval
Publication of CA2931064A1 publication Critical patent/CA2931064A1/en
Application granted granted Critical
Publication of CA2931064C publication Critical patent/CA2931064C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2931064A 2013-11-25 2014-11-25 Withanolides useful for the treatment of neurodegenerative diseases Active CA2931064C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361908455P 2013-11-25 2013-11-25
US61/908,455 2013-11-25
PCT/US2014/067436 WO2015077780A1 (en) 2013-11-25 2014-11-25 Withanolides useful for the treatment of neurodegenerative diseases

Publications (2)

Publication Number Publication Date
CA2931064A1 CA2931064A1 (en) 2015-05-28
CA2931064C true CA2931064C (en) 2022-10-18

Family

ID=52023694

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2931064A Active CA2931064C (en) 2013-11-25 2014-11-25 Withanolides useful for the treatment of neurodegenerative diseases

Country Status (14)

Country Link
US (1) US10351590B2 (https=)
EP (1) EP3074414B1 (https=)
JP (1) JP6517833B2 (https=)
KR (1) KR20160137945A (https=)
CN (1) CN105940010B (https=)
AU (1) AU2014352629B2 (https=)
BR (1) BR112016012002A2 (https=)
CA (1) CA2931064C (https=)
ES (1) ES2728870T3 (https=)
MX (1) MX364528B (https=)
PL (1) PL3074414T3 (https=)
TR (1) TR201905218T4 (https=)
WO (1) WO2015077780A1 (https=)
ZA (1) ZA201603117B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210079035A1 (en) * 2017-12-11 2021-03-18 Ethnodyne Compounds for treating neurodegenerative disorders
EP3723859B1 (en) * 2017-12-11 2023-08-30 Ethnodyne Compounds for treating neurodegenerative disorders
WO2019116069A1 (en) * 2017-12-11 2019-06-20 Ethnodyne Compounds for treating neurodegenerative disorders
CN111377994A (zh) * 2018-12-28 2020-07-07 南开大学 七种来源于灯笼果的醉茄内酯类化合物及其制备方法和用途
CN116063373B (zh) * 2023-02-14 2025-04-15 广西医科大学 天然产物27-Deoxywithaferin A的制备方法
TW202521103A (zh) * 2023-10-03 2025-06-01 美商恩維達醫療公司 醉茄素a（withaferin a）類似物及使用彼之治療方法
CN117924401A (zh) * 2024-01-22 2024-04-26 黑龙江中医药大学 一种具有神经炎症抑制活性的化合物及其提取方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010030395A2 (en) 2008-09-15 2010-03-18 Whitehead Institute For Biomedical Research Withaferin a analogs and uses thereof
WO2010053655A2 (en) * 2008-11-07 2010-05-14 University Of Kansas Therapeutic methods with withaferin a and analogs
WO2012106393A2 (en) * 2011-02-01 2012-08-09 University Of Kansas Withanolide isolated from physalis longifolia and analogs and methods of use thereof
CA2839777C (en) * 2011-06-22 2021-10-19 Universite Laval Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease

Also Published As

Publication number Publication date
US10351590B2 (en) 2019-07-16
ZA201603117B (en) 2020-05-27
CN105940010A (zh) 2016-09-14
WO2015077780A1 (en) 2015-05-28
US20170022247A1 (en) 2017-01-26
CN105940010B (zh) 2018-03-30
PL3074414T3 (pl) 2019-12-31
JP6517833B2 (ja) 2019-05-22
BR112016012002A2 (pt) 2017-09-19
TR201905218T4 (tr) 2019-05-21
AU2014352629A1 (en) 2016-05-26
MX364528B (es) 2019-04-30
MX2016006544A (es) 2016-12-12
AU2014352629B2 (en) 2019-03-28
EP3074414A1 (en) 2016-10-05
EP3074414B1 (en) 2019-01-09
KR20160137945A (ko) 2016-12-02
JP2016537432A (ja) 2016-12-01
ES2728870T3 (es) 2019-10-29
CA2931064A1 (en) 2015-05-28

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