CA2930324C - Aminopyridine derivatives as tam family kinase inhibitors - Google Patents
Aminopyridine derivatives as tam family kinase inhibitors Download PDFInfo
- Publication number
- CA2930324C CA2930324C CA2930324A CA2930324A CA2930324C CA 2930324 C CA2930324 C CA 2930324C CA 2930324 A CA2930324 A CA 2930324A CA 2930324 A CA2930324 A CA 2930324A CA 2930324 C CA2930324 C CA 2930324C
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- CA
- Canada
- Prior art keywords
- pyrazol
- pyridin
- amine
- compound
- oxadiazol
- Prior art date
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- -1 aralkynyl Chemical group 0.000 claims description 149
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 98
- 239000001257 hydrogen Substances 0.000 claims description 98
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 98
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 84
- 125000003118 aryl group Chemical group 0.000 claims description 75
- 125000001072 heteroaryl group Chemical group 0.000 claims description 75
- 125000000623 heterocyclic group Chemical group 0.000 claims description 75
- 125000000217 alkyl group Chemical group 0.000 claims description 61
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
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- Endocrinology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201361909830P | 2013-11-27 | 2013-11-27 | |
| US201361909828P | 2013-11-27 | 2013-11-27 | |
| US61/909,828 | 2013-11-27 | ||
| US61/909,830 | 2013-11-27 | ||
| PCT/US2014/067709 WO2015081257A2 (en) | 2013-11-27 | 2014-11-26 | Aminopyridine derivatives as tam family kinase inhibitors |
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| CA2930324A1 CA2930324A1 (en) | 2015-06-04 |
| CA2930324C true CA2930324C (en) | 2022-01-18 |
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| AU2018338314B2 (en) | 2017-09-22 | 2024-12-12 | Kymera Therapeutics, Inc | Protein degraders and uses thereof |
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| WO2020010210A1 (en) * | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Mertk degraders and uses thereof |
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| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| BR112021005054A2 (pt) * | 2018-09-18 | 2021-06-08 | Signalchem Lifesciences Corporation | terapia de combinação para tratamento contra câncer no sangue |
| SG11202105424PA (en) | 2018-11-30 | 2021-06-29 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12521438B2 (en) | 2019-06-10 | 2026-01-13 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| PH12022551522A1 (en) | 2019-12-23 | 2024-01-29 | Kymera Therapeutics Inc | Smarca degraders and uses thereof |
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| WO2008045978A1 (en) | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
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| EP2484679B1 (en) | 2006-12-29 | 2016-09-28 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substitued triazoles useful as axl inhibitors |
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| CA2710230C (en) | 2006-12-29 | 2016-02-23 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| EP2079736B1 (en) | 2006-12-29 | 2017-10-18 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| AU2008240188A1 (en) | 2007-04-13 | 2008-10-23 | Supergen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
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| SI2328888T1 (sl) * | 2008-07-09 | 2013-03-29 | Rigel Pharmaceuticals, Inc. | Premoščeni biciklični heteroaril substituirani triazoli, uporabni kot inhibitorji Axl |
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| EP2423208A1 (en) | 2010-08-28 | 2012-02-29 | Lead Discovery Center GmbH | Pharmaceutically active compounds as Axl inhibitors |
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| ES2759615T3 (es) | 2011-04-01 | 2020-05-11 | Univ Utah Res Found | Análogos de N-fenilpirimidina-2-amina sustituidos como inhibidores de la quinasa AXL |
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- 2014-11-26 CA CA2930324A patent/CA2930324C/en active Active
- 2014-11-26 EP EP14819178.6A patent/EP3074390B1/en active Active
- 2014-11-26 WO PCT/US2014/067709 patent/WO2015081257A2/en not_active Ceased
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| EP3074390A2 (en) | 2016-10-05 |
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| BR112016012146B1 (pt) | 2022-11-01 |
| BR112016012146A2 (pt) | 2017-08-08 |
| US11034685B2 (en) | 2021-06-15 |
| US11034686B2 (en) | 2021-06-15 |
| CN105764514A (zh) | 2016-07-13 |
| US20190152965A1 (en) | 2019-05-23 |
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| CN105764514B (zh) | 2019-07-12 |
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| US10233176B2 (en) | 2019-03-19 |
| KR20160091358A (ko) | 2016-08-02 |
| AU2014354711A1 (en) | 2016-06-02 |
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