CA2930089C - Fingolimod hydrochloride process - Google Patents
Fingolimod hydrochloride process Download PDFInfo
- Publication number
- CA2930089C CA2930089C CA2930089A CA2930089A CA2930089C CA 2930089 C CA2930089 C CA 2930089C CA 2930089 A CA2930089 A CA 2930089A CA 2930089 A CA2930089 A CA 2930089A CA 2930089 C CA2930089 C CA 2930089C
- Authority
- CA
- Canada
- Prior art keywords
- fingolimod
- octylphenyl
- fingolimod hydrochloride
- iii
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3696/MUM/2013 | 2013-11-25 | ||
| IN3696MU2013 IN2013MU03696A (enExample) | 2013-11-25 | 2014-11-14 | |
| PCT/IN2014/000720 WO2015092809A2 (en) | 2013-11-25 | 2014-11-14 | Fingolimod hydrochloride process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2930089A1 CA2930089A1 (en) | 2015-06-25 |
| CA2930089C true CA2930089C (en) | 2021-08-03 |
Family
ID=52823744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2930089A Active CA2930089C (en) | 2013-11-25 | 2014-11-14 | Fingolimod hydrochloride process |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9643914B2 (enExample) |
| EP (1) | EP3074374B1 (enExample) |
| CA (1) | CA2930089C (enExample) |
| ES (1) | ES2729404T3 (enExample) |
| IN (1) | IN2013MU03696A (enExample) |
| WO (1) | WO2015092809A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020165672A1 (en) | 2019-02-15 | 2020-08-20 | Shivalik Rasayan Limited | Process for preparation of highly pure fingolimod hydrochloride |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627406B1 (en) | 1992-10-21 | 1998-10-28 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| EP1457478B1 (en) | 1998-11-11 | 2017-07-19 | Novartis AG | Production of 2-amino-2-[2-(4-alkyl-phenyl)ethyl]propane-1,3-diols |
| US6423871B1 (en) * | 1999-02-26 | 2002-07-23 | University Of South Florida | Efficient synthesis of secondary amines by selective alkylation of primary amines |
| WO2012070059A1 (en) * | 2010-11-25 | 2012-05-31 | Shilpa Medicare Limited | Fingolimod polymorphs and their processes |
| US9216943B2 (en) | 2011-04-29 | 2015-12-22 | Dr. Reddy's Laboratories Ltd. | Preparation of fingolimod and its salts |
| EP2807143B1 (en) | 2012-01-25 | 2017-08-30 | Glenmark Generics Limited | Process for preparation of fingolimod |
-
2014
- 2014-11-14 US US15/035,306 patent/US9643914B2/en active Active
- 2014-11-14 ES ES14853182T patent/ES2729404T3/es active Active
- 2014-11-14 WO PCT/IN2014/000720 patent/WO2015092809A2/en not_active Ceased
- 2014-11-14 EP EP14853182.5A patent/EP3074374B1/en active Active
- 2014-11-14 CA CA2930089A patent/CA2930089C/en active Active
- 2014-11-14 IN IN3696MU2013 patent/IN2013MU03696A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015092809A2 (en) | 2015-06-25 |
| EP3074374A2 (en) | 2016-10-05 |
| ES2729404T3 (es) | 2019-11-04 |
| WO2015092809A3 (en) | 2015-08-13 |
| US20160289166A1 (en) | 2016-10-06 |
| CA2930089A1 (en) | 2015-06-25 |
| EP3074374B1 (en) | 2019-03-13 |
| US9643914B2 (en) | 2017-05-09 |
| IN2013MU03696A (enExample) | 2015-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4708792B2 (ja) | ２，６−ジアミノ−４，５，６，７−テトラヒドロ−ベンゾチアゾールの生産方法 | |
| WO2016079751A2 (en) | A process for preparation of vortioxetine and polymorphs thereof | |
| US8884046B2 (en) | Compounds useful in the synthesis of benzamide compounds | |
| US10836730B2 (en) | Process for preparation and purification of vortioxetine hydrobromide | |
| JP6185021B2 (ja) | 塩酸リトドリンの調製方法 | |
| CA2930089C (en) | Fingolimod hydrochloride process | |
| KR101098116B1 (ko) | 레바미피드의 개선된 제조 방법 | |
| JPWO2011001976A1 (ja) | スレオ−３−（３，４−ジヒドロキシフェニル）−ｌ−セリンの製造法 | |
| JP2009137955A (ja) | シクロアルキルおよびハロアルキルｏ−アミノフエニルケトン類の改良された製造方法 | |
| JP7453365B2 (ja) | 高純度のｎ－（５－メトキシ―２－フェノキシフェニル）メタンスルホンアミド及びその製造方法 | |
| US20120253051A1 (en) | Process for the preparation of ropinirole and salts thereof | |
| KR101557702B1 (ko) | 미티글리니드 칼슘 이수화물의 제조방법 | |
| JP2002030072A (ja) | １，３−ジヨードヒダントイン類の製造方法 | |
| EA011763B1 (ru) | Способы получения венлафаксина и формы i венлафаксина гидрохлорида | |
| CN108191828B (zh) | 一种来那度胺代谢物的合成方法 | |
| CN110621660B (zh) | 盐酸罗匹尼罗的纯化方法 | |
| US8586792B2 (en) | Process for the preparation of 4-iodo-3-nitrobenzamide | |
| JP3867309B2 (ja) | （ｅ）−２’，４’−ジクロロアセトフェノンオキシムの製造法 | |
| JP7361715B2 (ja) | 高純度コレステロールの製造方法 | |
| JP6275596B2 (ja) | テルミサルタンのアンモニウム塩の製造方法 | |
| JP3823385B2 (ja) | ２，４，５−トリフルオロ−３−ヨ−ド安息香酸およびそのエステル類の製造方法 | |
| JP2000198779A (ja) | ３―アルキルフラバノノ―ル誘導体の精製法 | |
| JP2007521224A (ja) | Ｒａｃ−ビカルタミドの精製及び単離方法 | |
| HU207709B (en) | Process for producing n-/n-propyl/-n-/2-/2,4,6-trichloro-phenoxy/-ethyl/-amine | |
| EP2277852B1 (en) | Synthesis of iodixanol in water |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190814 |