CA2930042C - Prrs virus variant, european prrs virus cdna clone, and uses thereof - Google Patents

Prrs virus variant, european prrs virus cdna clone, and uses thereof Download PDF

Info

Publication number
CA2930042C
CA2930042C CA2930042A CA2930042A CA2930042C CA 2930042 C CA2930042 C CA 2930042C CA 2930042 A CA2930042 A CA 2930042A CA 2930042 A CA2930042 A CA 2930042A CA 2930042 C CA2930042 C CA 2930042C
Authority
CA
Canada
Prior art keywords
virus
nucleic acid
seq
sequence
prrs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2930042A
Other languages
English (en)
French (fr)
Other versions
CA2930042A1 (en
Inventor
Andreas GALLEI
Christoph Keller
Erik SCHACHT
Marieke HERREL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica GmbH filed Critical Boehringer Ingelheim Vetmedica GmbH
Publication of CA2930042A1 publication Critical patent/CA2930042A1/en
Application granted granted Critical
Publication of CA2930042C publication Critical patent/CA2930042C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10021Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10041Use of virus, viral particle or viral elements as a vector
    • C12N2770/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2930042A 2013-12-20 2014-12-19 Prrs virus variant, european prrs virus cdna clone, and uses thereof Active CA2930042C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13199177.0 2013-12-20
EP13199177 2013-12-20
EP14175691.6 2014-07-03
EP14175691 2014-07-03
PCT/EP2014/078929 WO2015092058A1 (en) 2013-12-20 2014-12-19 Prrs virus variant, european prrs virus cdna clone, and uses thereof

Publications (2)

Publication Number Publication Date
CA2930042A1 CA2930042A1 (en) 2015-06-25
CA2930042C true CA2930042C (en) 2022-06-21

Family

ID=52347295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2930042A Active CA2930042C (en) 2013-12-20 2014-12-19 Prrs virus variant, european prrs virus cdna clone, and uses thereof

Country Status (13)

Country Link
US (2) US10010601B2 (cg-RX-API-DMAC7.html)
EP (2) EP3591042B1 (cg-RX-API-DMAC7.html)
JP (3) JP6886291B2 (cg-RX-API-DMAC7.html)
KR (2) KR102446025B1 (cg-RX-API-DMAC7.html)
CN (1) CN105829528B (cg-RX-API-DMAC7.html)
AU (2) AU2014369774B2 (cg-RX-API-DMAC7.html)
CA (1) CA2930042C (cg-RX-API-DMAC7.html)
DK (2) DK3083947T3 (cg-RX-API-DMAC7.html)
EA (1) EA039060B1 (cg-RX-API-DMAC7.html)
ES (2) ES2940691T3 (cg-RX-API-DMAC7.html)
HU (1) HUE061768T2 (cg-RX-API-DMAC7.html)
MX (2) MX375528B (cg-RX-API-DMAC7.html)
WO (1) WO2015092058A1 (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2826341C (en) 2011-02-17 2022-02-22 Boehringer Ingelheim Vetmedica Gmbh Live attenuated strain of european prrsv and vaccines thereof
BR112013020966B1 (pt) 2011-02-17 2020-05-26 Boehringer Ingelheim Vetmedica Gmbh Processo em escala comercial para produção do prrsv
DK3083947T3 (da) 2013-12-20 2019-07-08 Boehringer Ingelheim Vetmedica Gmbh Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf
US11332739B2 (en) 2016-08-05 2022-05-17 Hipra Scientific, S.L.U. Porcine reproductive and respiratory syndrome virus cDNA clone and uses thereof
KR102335864B1 (ko) * 2018-12-27 2021-12-06 주식회사 바이오포아 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신
WO2020138761A1 (ko) * 2018-12-27 2020-07-02 주식회사 바이오포아 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신
AU2019463018B2 (en) 2019-08-29 2025-11-06 Elanco Uk Ah Limited Porcine reproductive and respiratory syndrome vaccine virus
CN110894243B (zh) * 2019-12-16 2021-07-13 中国农业大学 一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条
CN116134131A (zh) 2019-12-31 2023-05-16 伊利克斯根治疗公司 核酸和蛋白质向细胞和组织的基于温度的瞬时递送
JP2021153692A (ja) * 2020-03-25 2021-10-07 株式会社三共 遊技機
KR102319508B1 (ko) * 2020-07-27 2021-10-28 연세대학교 산학협력단 인체 감염형 낙타 유래 메르스코로나바이러스 검출용 바이오마커 및 이의 용도
CN113969267B (zh) * 2021-11-15 2024-02-27 中国农业大学 一种猪繁殖与呼吸综合征突变病毒及其构建方法与应用
WO2024077281A2 (en) * 2022-10-06 2024-04-11 Cornell University Genotyping and sequencing assays for prrsv
KR20240146158A (ko) * 2023-03-27 2024-10-08 주식회사 케어사이드 돼지생식기호흡기증후군 키메릭 바이러스 및 이를 이용한 백신 조성물

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
EP0000062A1 (en) 1977-06-07 1978-12-20 Joseph George Spitzer Vapor tap valve for aerosol containers used with inflammable propellants, and container provided therewith
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
ZA864879B (en) 1985-07-08 1987-03-25 Wallone Region Vaccines and diagnostics derived from boving diarrhoea virus
NZ222465A (en) 1986-11-07 1992-11-25 Pasteur Institut Nanb (non a, non b hepatitis viral) antigen
CA2290906C (en) 1991-06-06 2003-04-01 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
JPH07501049A (ja) 1991-10-14 1995-02-02 アクゾ・ノベル・エヌ・ベー ブタ生殖・呼吸系症候群ワクチン及び診断方法
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
DE69522984T2 (de) 1994-04-11 2002-04-25 Akzo Nobel Nv Europäische Vakzinstämme des Fortplanzungs-Atmungs-Syndromsvirus des Schweins
DK53595A (da) 1994-05-13 1995-11-14 Iberica Cyanamid Rekombinante PRRSV-proteiner, diagnostiske kits og vaccine indeholdende sådanne rekombinante PRRSV-proteiner
DK0732340T3 (da) 1995-03-14 2004-10-25 Akzo Nobel Nv Ekspression af porcine reproduktions- og respirationssyndromviruspolypeptider i den samme celle
ES2102971B1 (es) 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
US5866401A (en) 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
DK0835930T3 (da) 1996-10-09 2001-06-18 Akzo Nobel Nv Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV)
US20040224327A1 (en) 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
CA2289980C (en) 1997-05-06 2010-07-20 Antonie Paul Van Nieuwstadt Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
NZ501264A (en) * 1998-12-22 2001-09-28 Pfizer Prod Inc Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS
JP3961222B2 (ja) 1999-03-08 2007-08-22 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Prrsvワクチン
ES2348159T3 (es) 1999-04-22 2010-11-30 United States Department Of Agriculture Vacuna contra el sindrome respiratorio y reproductivo porcino basada en el aislado ja-142.
WO2002095040A1 (en) 2001-05-21 2002-11-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Delections in arterivirus replicons
WO2001059077A1 (en) 2000-02-08 2001-08-16 Regents Of The University Of Minnesota Porcine reproductive and respiratory syndrome virus and methods of use
EP1156111A1 (en) 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
EP1350840B1 (en) 2002-04-05 2012-05-09 Boehringer Ingelheim Vetmedica GmbH Adaptation sites of PRRSV
US7722878B2 (en) 2004-06-17 2010-05-25 Boehringer Ingelheim Vetmedica, Inc. PRRSV subunit vaccines
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
DE602006013270D1 (en) 2005-01-13 2010-05-12 Boehringer Ingelheim Vetmed Prrs-impfstoffe
WO2008121958A1 (en) 2007-04-02 2008-10-09 Boehringer Ingelheim Vetmedica, Inc. Use of prrsv vaccines to reduce pcv2 viremia
ES2389748T3 (es) * 2007-06-25 2012-10-31 South Dakota State University Virus del síndrome reproductivo y respiratorio porcino de tipo 1 norteamericano recombinante y métodos de uso
US20110117129A1 (en) 2008-08-25 2011-05-19 Boehringer Ingelheim Vetmedica, Inc. Vaccine Against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome (HP PRRS)
WO2010084648A1 (ja) 2009-01-20 2010-07-29 シャープ株式会社 照明装置、表示装置、及びテレビ受信装置
ES2742262T3 (es) 2010-04-16 2020-02-13 Univ Gent Vacuna con protección cruzada para el virus del síndrome respiratorio y reproductivo porcino
BR112013020966B1 (pt) 2011-02-17 2020-05-26 Boehringer Ingelheim Vetmedica Gmbh Processo em escala comercial para produção do prrsv
CA2826341C (en) 2011-02-17 2022-02-22 Boehringer Ingelheim Vetmedica Gmbh Live attenuated strain of european prrsv and vaccines thereof
WO2013017568A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
JP6260972B2 (ja) * 2012-02-14 2018-01-17 メリアル インコーポレイテッド 狂犬病タンパク質及びox40タンパク質の両方を発現する組換えポックスウイルスベクター並びに前記ベクターから製造されるワクチン
MX2014013964A (es) * 2012-05-17 2015-03-04 Zoetis Llc Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete.
EP2968513A2 (en) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
CN105829906B (zh) * 2013-12-19 2020-11-03 皇家飞利浦有限公司 具有水/脂肪分离的相位敏感的反转恢复mri
DK3083947T3 (da) 2013-12-20 2019-07-08 Boehringer Ingelheim Vetmedica Gmbh Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf

Also Published As

Publication number Publication date
ES2729838T3 (es) 2019-11-06
CN105829528B (zh) 2019-10-22
KR102270344B1 (ko) 2021-07-01
JP2021104028A (ja) 2021-07-26
DK3591042T3 (da) 2023-04-17
MX375528B (es) 2025-03-06
AU2014369774B2 (en) 2020-11-26
KR102446025B1 (ko) 2022-09-22
EP3591042A1 (en) 2020-01-08
MX2016007737A (es) 2016-09-07
KR20160099099A (ko) 2016-08-19
CA2930042A1 (en) 2015-06-25
US10639364B2 (en) 2020-05-05
DK3083947T3 (da) 2019-07-08
US10010601B2 (en) 2018-07-03
MX2020010248A (es) 2020-10-16
JP2017502662A (ja) 2017-01-26
JP2020054380A (ja) 2020-04-09
EP3083947A1 (en) 2016-10-26
EA201600476A1 (ru) 2016-11-30
HUE061768T2 (hu) 2023-08-28
DK3591042T5 (da) 2024-09-02
AU2021201224A1 (en) 2021-03-11
EP3591042B1 (en) 2023-01-25
EP3083947B1 (en) 2019-04-03
US20160317642A1 (en) 2016-11-03
EA039060B1 (ru) 2021-11-29
US20190151432A1 (en) 2019-05-23
ES2940691T3 (es) 2023-05-10
AU2014369774A1 (en) 2016-04-21
WO2015092058A1 (en) 2015-06-25
JP7158523B2 (ja) 2022-10-21
AU2021201224B2 (en) 2023-06-15
KR20210080606A (ko) 2021-06-30
CN105829528A (zh) 2016-08-03
JP6886291B2 (ja) 2021-06-16

Similar Documents

Publication Publication Date Title
US10639364B2 (en) PRRS virus variant, european PRRS virus cDNA clone, and uses thereof
JP6997574B2 (ja) ブタ生殖および呼吸症候群(prrs)ウイルスに対する離乳前の効果的なワクチン接種
US9187731B2 (en) PRRS virus inducing type I interferon in susceptible cells
US9315781B2 (en) Infectious CDNA clone of european PRRS virus and uses thereof
Li et al. Mutations in a highly conserved motif of nsp1β protein attenuate the innate immune suppression function of porcine reproductive and respiratory syndrome virus
Kimpston-Burkgren et al. Relative contribution of porcine reproductive and respiratory syndrome virus open reading frames 2–4 to the induction of protective immunity
Sun et al. Identification of viral genes associated with the interferon-inducing phenotype of a synthetic porcine reproductive and respiratory syndrome virus strain
KR101253692B1 (ko) 돼지생식기호흡기증후군 바이러스 감수성 세포주
TW201319083A (zh) 於易感細胞內誘發第i型干擾素之新穎prrs病毒
EA044385B1 (ru) Вариант вируса ррсс, клон кднк вируса ррсс европейского типа и их применение
Sun Study of a Synthetic Porcine Reproductive and Respiratory Syndrome Virus Strain as a Vaccine Candidate

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20191205

EEER Examination request

Effective date: 20191205