CA2930042C - Prrs virus variant, european prrs virus cdna clone, and uses thereof - Google Patents
Prrs virus variant, european prrs virus cdna clone, and uses thereof Download PDFInfo
- Publication number
- CA2930042C CA2930042C CA2930042A CA2930042A CA2930042C CA 2930042 C CA2930042 C CA 2930042C CA 2930042 A CA2930042 A CA 2930042A CA 2930042 A CA2930042 A CA 2930042A CA 2930042 C CA2930042 C CA 2930042C
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- Prior art keywords
- virus
- nucleic acid
- seq
- sequence
- prrs
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10041—Use of virus, viral particle or viral elements as a vector
- C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199177 | 2013-12-20 | ||
| EP13199177.0 | 2013-12-20 | ||
| EP14175691.6 | 2014-07-03 | ||
| EP14175691 | 2014-07-03 | ||
| PCT/EP2014/078929 WO2015092058A1 (en) | 2013-12-20 | 2014-12-19 | Prrs virus variant, european prrs virus cdna clone, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2930042A1 CA2930042A1 (en) | 2015-06-25 |
| CA2930042C true CA2930042C (en) | 2022-06-21 |
Family
ID=52347295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2930042A Active CA2930042C (en) | 2013-12-20 | 2014-12-19 | Prrs virus variant, european prrs virus cdna clone, and uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10010601B2 (OSRAM) |
| EP (2) | EP3083947B1 (OSRAM) |
| JP (3) | JP6886291B2 (OSRAM) |
| KR (2) | KR102270344B1 (OSRAM) |
| CN (1) | CN105829528B (OSRAM) |
| AU (2) | AU2014369774B2 (OSRAM) |
| CA (1) | CA2930042C (OSRAM) |
| DK (2) | DK3591042T5 (OSRAM) |
| EA (1) | EA039060B1 (OSRAM) |
| ES (2) | ES2729838T3 (OSRAM) |
| HU (1) | HUE061768T2 (OSRAM) |
| MX (2) | MX375528B (OSRAM) |
| WO (1) | WO2015092058A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12017500962B1 (en) | 2011-02-17 | 2023-02-22 | Boehringer Ingelheim Vetmedica Gmbh | Novel european prrsv strain |
| EP2675476B1 (en) | 2011-02-17 | 2015-09-16 | Boehringer Ingelheim Vetmedica GmbH | Commercial scale process for production of prrsv |
| AU2014369774B2 (en) | 2013-12-20 | 2020-11-26 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus variant, European PRRS virus cDNA clone, and uses thereof |
| MX393666B (es) | 2016-08-05 | 2025-03-24 | Hipra Scient S L U | CLON DE ADNc DEL VIRUS DEL SÍNDROME REPRODUCTIVO Y RESPIRATORIO PORCINO Y USOS DEL MISMO. |
| KR102335864B1 (ko) * | 2018-12-27 | 2021-12-06 | 주식회사 바이오포아 | 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신 |
| WO2020138761A1 (ko) * | 2018-12-27 | 2020-07-02 | 주식회사 바이오포아 | 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신 |
| US12214032B2 (en) * | 2019-08-29 | 2025-02-04 | Elanco Uk Ah Limited | Porcine Reproductive and Respiratory Syndrome vaccine virus |
| CN110894243B (zh) * | 2019-12-16 | 2021-07-13 | 中国农业大学 | 一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条 |
| CA3162690A1 (en) * | 2019-12-31 | 2021-07-08 | Minoru S. H. Ko | Temperature-based transient delivery of nucleic acids and proteins to cells and tissues |
| JP2021153692A (ja) * | 2020-03-25 | 2021-10-07 | 株式会社三共 | 遊技機 |
| KR102319508B1 (ko) * | 2020-07-27 | 2021-10-28 | 연세대학교 산학협력단 | 인체 감염형 낙타 유래 메르스코로나바이러스 검출용 바이오마커 및 이의 용도 |
| CN113969267B (zh) * | 2021-11-15 | 2024-02-27 | 中国农业大学 | 一种猪繁殖与呼吸综合征突变病毒及其构建方法与应用 |
| WO2024077281A2 (en) * | 2022-10-06 | 2024-04-11 | Cornell University | Genotyping and sequencing assays for prrsv |
| KR20240146158A (ko) * | 2023-03-27 | 2024-10-08 | 주식회사 케어사이드 | 돼지생식기호흡기증후군 키메릭 바이러스 및 이를 이용한 백신 조성물 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3137631A (en) | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
| US3959457A (en) | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
| US4015100A (en) | 1974-01-07 | 1977-03-29 | Avco Everett Research Laboratory, Inc. | Surface modification |
| EP0000062A1 (en) | 1977-06-07 | 1978-12-20 | Joseph George Spitzer | Vapor tap valve for aerosol containers used with inflammable propellants, and container provided therewith |
| US4205060A (en) | 1978-12-20 | 1980-05-27 | Pennwalt Corporation | Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use |
| ZA864879B (en) | 1985-07-08 | 1987-03-25 | Wallone Region | Vaccines and diagnostics derived from boving diarrhoea virus |
| NZ222465A (en) | 1986-11-07 | 1992-11-25 | Pasteur Institut | Nanb (non a, non b hepatitis viral) antigen |
| AU2196592A (en) | 1991-06-06 | 1993-01-08 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| WO1993007898A1 (en) | 1991-10-14 | 1993-04-29 | Akzo Nobel N.V. | Porcine reproductive respiratory syndrome vaccine and diagnostic |
| FR2686097B1 (fr) | 1992-01-14 | 1994-12-30 | Rhone Merieux | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
| US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
| ES2074950B1 (es) | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
| EP0676467B1 (en) | 1994-04-11 | 2001-10-04 | Akzo Nobel N.V. | European vaccine strains of the porcine reproductive respiratory syndrome virus (PRRSV) |
| GB2289279B (en) | 1994-05-13 | 1998-09-16 | Iberica Cyanamid | Diagnostic kits and vaccines containing recombinant PRRSV proteins |
| ES2223058T3 (es) | 1995-03-14 | 2005-02-16 | Akzo Nobel N.V. | Expresion en la misma celula de polipeptidos del virus del sindrome reproductivo y respiratorio porcino. |
| ES2102971B1 (es) | 1996-01-25 | 1998-03-01 | Hipra Lab Sa | Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion. |
| US5866401A (en) | 1996-03-01 | 1999-02-02 | Schering Corporation | Porcine reproductive and respiratory syndrome vaccine |
| DK0835930T3 (da) | 1996-10-09 | 2001-06-18 | Akzo Nobel Nv | Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV) |
| EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| US20040224327A1 (en) | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| ATE365746T1 (de) | 1997-05-06 | 2007-07-15 | Boehringer Ingelheim Vetmed | Prrsv-antigene, die auf peptidsequenzen des prrs- virus basieren, für die verwendung als impfstoff und für diagnostische tests |
| NZ501264A (en) * | 1998-12-22 | 2001-09-28 | Pfizer Prod Inc | Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS |
| JP3961222B2 (ja) | 1999-03-08 | 2007-08-22 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | Ｐｒｒｓｖワクチン |
| CA2370372C (en) | 1999-04-22 | 2009-02-24 | United States Department Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
| WO2002095040A1 (en) | 2001-05-21 | 2002-11-28 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Delections in arterivirus replicons |
| DK1255815T3 (da) | 2000-02-08 | 2006-10-30 | Univ Minnesota | Porcint reproduktivt og respiratorisk syndromvirus til fremgangsmåder til anvendelse |
| EP1156111A1 (en) | 2000-05-19 | 2001-11-21 | Stichting Dienst Landbouwkundig Onderzoek | Chimeric arterivirus-like particles |
| ATE557082T1 (de) | 2002-04-05 | 2012-05-15 | Boehringer Ingelheim Vetmed | Sequenz positionen zur anpassung bei prrsv |
| US7722878B2 (en) | 2004-06-17 | 2010-05-25 | Boehringer Ingelheim Vetmedica, Inc. | PRRSV subunit vaccines |
| US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
| EP1838343B1 (en) | 2005-01-13 | 2010-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Prrs vaccines |
| WO2008121958A1 (en) | 2007-04-02 | 2008-10-09 | Boehringer Ingelheim Vetmedica, Inc. | Use of prrsv vaccines to reduce pcv2 viremia |
| JP2010531143A (ja) * | 2007-06-25 | 2010-09-24 | サウス ダコタ ステート ユニバーシティー | 組換え北アメリカ１型ブタ生殖器呼吸器症候群ウイルス及び使用方法 |
| CN102316895A (zh) | 2008-08-25 | 2012-01-11 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 抗高致病性猪生殖与呼吸综合征(hp prrs)的疫苗 |
| WO2010084648A1 (ja) | 2009-01-20 | 2010-07-29 | シャープ株式会社 | 照明装置、表示装置、及びテレビ受信装置 |
| DK2558118T3 (da) | 2010-04-16 | 2019-08-26 | Univ Gent | Krydsbeskyttende vaccine mod reproduktions- og respirationssyndromvirus hos svin |
| PH12017500962B1 (en) * | 2011-02-17 | 2023-02-22 | Boehringer Ingelheim Vetmedica Gmbh | Novel european prrsv strain |
| EP2675476B1 (en) | 2011-02-17 | 2015-09-16 | Boehringer Ingelheim Vetmedica GmbH | Commercial scale process for production of prrsv |
| EP2737058A1 (en) | 2011-07-29 | 2014-06-04 | Boehringer Ingelheim Vetmedica GmbH | INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF |
| AU2013221502C1 (en) * | 2012-02-14 | 2018-03-01 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant poxviral vectors expressing both rabies and OX40 proteins, and vaccines made therefrom |
| CN105688201A (zh) * | 2012-05-17 | 2016-06-22 | 佐蒂斯有限责任公司 | 在断奶之前对抗猪繁殖与呼吸综合征（prrs）病毒的有效疫苗接种 |
| CN105073130A (zh) | 2013-03-15 | 2015-11-18 | 勃林格殷格翰动物保健公司 | 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法 |
| JP6581584B2 (ja) * | 2013-12-19 | 2019-09-25 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 水／脂肪分離を用いた位相感応型反転回復ｍｒｉ |
| AU2014369774B2 (en) | 2013-12-20 | 2020-11-26 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus variant, European PRRS virus cDNA clone, and uses thereof |
-
2014
- 2014-12-19 AU AU2014369774A patent/AU2014369774B2/en active Active
- 2014-12-19 EP EP14827219.8A patent/EP3083947B1/en active Active
- 2014-12-19 EA EA201600476A patent/EA039060B1/ru unknown
- 2014-12-19 MX MX2016007737A patent/MX375528B/es active IP Right Grant
- 2014-12-19 CN CN201480068965.2A patent/CN105829528B/zh active Active
- 2014-12-19 ES ES14827219T patent/ES2729838T3/es active Active
- 2014-12-19 MX MX2020010248A patent/MX2020010248A/es unknown
- 2014-12-19 DK DK19165389.8T patent/DK3591042T5/da active
- 2014-12-19 KR KR1020167019672A patent/KR102270344B1/ko active Active
- 2014-12-19 EP EP19165389.8A patent/EP3591042B1/en active Active
- 2014-12-19 KR KR1020217019360A patent/KR102446025B1/ko active Active
- 2014-12-19 US US15/105,760 patent/US10010601B2/en active Active
- 2014-12-19 ES ES19165389T patent/ES2940691T3/es active Active
- 2014-12-19 HU HUE19165389A patent/HUE061768T2/hu unknown
- 2014-12-19 DK DK14827219.8T patent/DK3083947T3/da active
- 2014-12-19 CA CA2930042A patent/CA2930042C/en active Active
- 2014-12-19 WO PCT/EP2014/078929 patent/WO2015092058A1/en not_active Ceased
- 2014-12-19 JP JP2016540591A patent/JP6886291B2/ja active Active
-
2018
- 2018-06-01 US US15/995,560 patent/US10639364B2/en active Active
-
2019
- 2019-12-20 JP JP2019230014A patent/JP2020054380A/ja not_active Withdrawn
-
2021
- 2021-02-25 AU AU2021201224A patent/AU2021201224B2/en active Active
- 2021-03-24 JP JP2021049537A patent/JP7158523B2/ja active Active
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