CA2929937C - Hiv-1 envelope proteins and fragments thereof that possess epitopes recognized by broadly neutralizing antibodies - Google Patents
Hiv-1 envelope proteins and fragments thereof that possess epitopes recognized by broadly neutralizing antibodies Download PDFInfo
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- CA2929937C CA2929937C CA2929937A CA2929937A CA2929937C CA 2929937 C CA2929937 C CA 2929937C CA 2929937 A CA2929937 A CA 2929937A CA 2929937 A CA2929937 A CA 2929937A CA 2929937 C CA2929937 C CA 2929937C
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- hiv
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- rgp120
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699680P | 2012-09-11 | 2012-09-11 | |
| US61/699,680 | 2012-09-11 | ||
| PCT/US2013/059243 WO2014043220A2 (en) | 2012-09-11 | 2013-09-11 | Hiv-1 envelope proteins and fragments thereof that possess epitopes recognized by broadly neutralizing antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2929937A1 CA2929937A1 (en) | 2014-03-20 |
| CA2929937C true CA2929937C (en) | 2020-01-07 |
Family
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| AU2012279018B2 (en) | 2011-07-05 | 2017-06-08 | Children's Medical Center Corporation | N-terminal deleted GP120 immunogens |
| WO2013052095A2 (en) | 2011-10-03 | 2013-04-11 | Duke University | Vaccine |
| WO2017023857A1 (en) * | 2015-08-01 | 2017-02-09 | The Regents Of The University Of California | Polypeptide glycopeptide fragments from the v1/v2 and v3 domains of the hiv-1 envelope protein gp 120 |
| CN106800603B (zh) * | 2017-01-24 | 2020-07-28 | 中国食品药品检定研究院 | 检测抗hiv抗体的adcc活性的方法 |
| WO2019018310A1 (en) * | 2017-07-19 | 2019-01-24 | The Regents Of The University Of California | MGAT1-IMPROVED CELLS FOR THE PRODUCTION OF VACCINES AND BIOPHARMACEUTICAL PRODUCTS |
| US20210317168A1 (en) * | 2018-10-15 | 2021-10-14 | The Regents Of The University Of California | Complement Component 1s (C1s) Deficient Cells for Production of Vaccines and Biopharmaceutical Proteins |
| WO2020117740A1 (en) * | 2018-12-03 | 2020-06-11 | International Aids Vaccine Initiative | Recombinant hiv env polypeptides and their uses |
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| EP1109575A2 (en) * | 1998-09-29 | 2001-06-27 | University of Kansas Medical Center | Live virus vaccines to protect primates from hiv-1 infection and disease |
| CA2562385A1 (en) * | 2004-04-09 | 2005-10-20 | University Of Manitoba | Identification of the precise amino acid sequence of the epitope recognized by the potent neutralizing human anti-hiv-1 monoclonal antibody igg1b12 |
| US9782472B2 (en) | 2008-10-04 | 2017-10-10 | The Regents Of The University Of California | Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity |
| CA2757079C (en) * | 2009-04-20 | 2015-05-19 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| WO2011008863A2 (en) * | 2009-07-14 | 2011-01-20 | Lucia Irene Gonzalez | Stereoisomer peptides and their polymer conjugates for hiv disease |
| EP2588211A4 (en) * | 2010-06-30 | 2014-03-05 | Torrey Pines Inst | EPS TRIMER-IMMUNOGENIC |
| EP2788026A4 (en) | 2011-12-05 | 2015-08-05 | Univ Duke | V1V2 IMMUNOGENIC |
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| US9731002B2 (en) | 2017-08-15 |
| US10507239B2 (en) | 2019-12-17 |
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| CA2929937A1 (en) | 2014-03-20 |
| WO2014043220A3 (en) | 2016-10-27 |
| EP2928492A2 (en) | 2015-10-14 |
| EP2928492A4 (en) | 2017-09-13 |
| WO2014043220A2 (en) | 2014-03-20 |
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